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Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study

Accumulating evidence suggests vascular dysregulation in preclinical Alzheimer’s disease. In this study, cerebral hemodynamics and their coupling with cognition in middle-aged apolipoprotein ε4 carriers (APOEε4+) were investigated. Longitudinal 3 T T1-weighted and arterial spin labelling MRI data fr...

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Autores principales: Dounavi, Maria-Eleni, Low, Audrey, McKiernan, Elizabeth F, Mak, Elijah, Muniz-Terrera, Graciela, Ritchie, Karen, Ritchie, Craig W, Su, Li, O’Brien, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543665/
https://www.ncbi.nlm.nih.gov/pubmed/34078163
http://dx.doi.org/10.1177/0271678X211020863
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author Dounavi, Maria-Eleni
Low, Audrey
McKiernan, Elizabeth F
Mak, Elijah
Muniz-Terrera, Graciela
Ritchie, Karen
Ritchie, Craig W
Su, Li
O’Brien, John T.
author_facet Dounavi, Maria-Eleni
Low, Audrey
McKiernan, Elizabeth F
Mak, Elijah
Muniz-Terrera, Graciela
Ritchie, Karen
Ritchie, Craig W
Su, Li
O’Brien, John T.
author_sort Dounavi, Maria-Eleni
collection PubMed
description Accumulating evidence suggests vascular dysregulation in preclinical Alzheimer’s disease. In this study, cerebral hemodynamics and their coupling with cognition in middle-aged apolipoprotein ε4 carriers (APOEε4+) were investigated. Longitudinal 3 T T1-weighted and arterial spin labelling MRI data from 158 participants (40–59 years old) in the PREVENT-Dementia study were analysed (125 two-year follow-up). Cognition was evaluated using the COGNITO battery. Cerebral blood flow (CBF) and cerebrovascular resistance index (CVRi) were quantified for the flow territories of the anterior, middle and posterior cerebral arteries. CBF was corrected for underlying atrophy and individual hematocrit. Hemodynamic measures were the dependent variables in linear regression models, with age, sex, years of education and APOEε4 carriership as predictors. Further analyses were conducted with cognitive outcomes as dependent variables, using the same model as before with additional APOEε4 × hemodynamics interactions. At baseline, APOEε4+ showed increased CBF and decreased CVRi compared to non-carriers in the anterior and middle cerebral arteries, suggestive of potential vasodilation. Hemodynamic changes were similar between groups. Interaction analysis revealed positive associations between CBF changes and performance changes in delayed recall (for APOEε4 non-carriers) and verbal fluency (for APOEε4 carriers) cognitive tests. These observations are consistent with neurovascular dysregulation in middle-aged APOEε4+.
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spelling pubmed-85436652021-10-26 Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study Dounavi, Maria-Eleni Low, Audrey McKiernan, Elizabeth F Mak, Elijah Muniz-Terrera, Graciela Ritchie, Karen Ritchie, Craig W Su, Li O’Brien, John T. J Cereb Blood Flow Metab Original Articles Accumulating evidence suggests vascular dysregulation in preclinical Alzheimer’s disease. In this study, cerebral hemodynamics and their coupling with cognition in middle-aged apolipoprotein ε4 carriers (APOEε4+) were investigated. Longitudinal 3 T T1-weighted and arterial spin labelling MRI data from 158 participants (40–59 years old) in the PREVENT-Dementia study were analysed (125 two-year follow-up). Cognition was evaluated using the COGNITO battery. Cerebral blood flow (CBF) and cerebrovascular resistance index (CVRi) were quantified for the flow territories of the anterior, middle and posterior cerebral arteries. CBF was corrected for underlying atrophy and individual hematocrit. Hemodynamic measures were the dependent variables in linear regression models, with age, sex, years of education and APOEε4 carriership as predictors. Further analyses were conducted with cognitive outcomes as dependent variables, using the same model as before with additional APOEε4 × hemodynamics interactions. At baseline, APOEε4+ showed increased CBF and decreased CVRi compared to non-carriers in the anterior and middle cerebral arteries, suggestive of potential vasodilation. Hemodynamic changes were similar between groups. Interaction analysis revealed positive associations between CBF changes and performance changes in delayed recall (for APOEε4 non-carriers) and verbal fluency (for APOEε4 carriers) cognitive tests. These observations are consistent with neurovascular dysregulation in middle-aged APOEε4+. SAGE Publications 2021-06-02 2021-11 /pmc/articles/PMC8543665/ /pubmed/34078163 http://dx.doi.org/10.1177/0271678X211020863 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Dounavi, Maria-Eleni
Low, Audrey
McKiernan, Elizabeth F
Mak, Elijah
Muniz-Terrera, Graciela
Ritchie, Karen
Ritchie, Craig W
Su, Li
O’Brien, John T.
Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study
title Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study
title_full Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study
title_fullStr Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study
title_full_unstemmed Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study
title_short Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study
title_sort evidence of cerebral hemodynamic dysregulation in middle-aged apoe ε4 carriers: the prevent-dementia study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543665/
https://www.ncbi.nlm.nih.gov/pubmed/34078163
http://dx.doi.org/10.1177/0271678X211020863
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