Cargando…

A case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy

Recurrent respiratory papillomatosis is a human papillomavirus-mediated condition characterised by the development of benign squamous papillomata of the respiratory tract. Malignant transformation of recurrent respiratory papillomatosis, while rare, carries a poor prognosis and there are limited dat...

Descripción completa

Detalles Bibliográficos
Autores principales: Kovacs, Aaron C, Vodanovich, Domagoj, Mogridge, Emily K, Wun, Lisa, Corry, June
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543711/
https://www.ncbi.nlm.nih.gov/pubmed/34707869
http://dx.doi.org/10.1177/2050313X211054623
_version_ 1784589671961985024
author Kovacs, Aaron C
Vodanovich, Domagoj
Mogridge, Emily K
Wun, Lisa
Corry, June
author_facet Kovacs, Aaron C
Vodanovich, Domagoj
Mogridge, Emily K
Wun, Lisa
Corry, June
author_sort Kovacs, Aaron C
collection PubMed
description Recurrent respiratory papillomatosis is a human papillomavirus-mediated condition characterised by the development of benign squamous papillomata of the respiratory tract. Malignant transformation of recurrent respiratory papillomatosis, while rare, carries a poor prognosis and there are limited data surrounding treatment options, particularly in inoperable disease. We present the case of a 64-year-old male who developed malignant airway obstruction secondary to primary tracheal squamous cell carcinoma in the setting of a 5-year history of recurrent laryngotracheal papillomatosis, requiring placement of tracheostomy while on veno-venous extracorporeal membranous oxygenation. He was managed with cisplatin-based definitive chemoradiotherapy and had a complete metabolic response on post-treatment positron emission tomography/computed tomography, and remains free of recurrent squamous cell carcinoma at 16 months following treatment. This case supports the use of combined chemoradiotherapy as a potential therapeutic option for patients with primary tracheal squamous cell carcinoma, and emphasises the challenges associated with the long-term management of recurrent respiratory papillomatosis.
format Online
Article
Text
id pubmed-8543711
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-85437112021-10-26 A case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy Kovacs, Aaron C Vodanovich, Domagoj Mogridge, Emily K Wun, Lisa Corry, June SAGE Open Med Case Rep Case Report Recurrent respiratory papillomatosis is a human papillomavirus-mediated condition characterised by the development of benign squamous papillomata of the respiratory tract. Malignant transformation of recurrent respiratory papillomatosis, while rare, carries a poor prognosis and there are limited data surrounding treatment options, particularly in inoperable disease. We present the case of a 64-year-old male who developed malignant airway obstruction secondary to primary tracheal squamous cell carcinoma in the setting of a 5-year history of recurrent laryngotracheal papillomatosis, requiring placement of tracheostomy while on veno-venous extracorporeal membranous oxygenation. He was managed with cisplatin-based definitive chemoradiotherapy and had a complete metabolic response on post-treatment positron emission tomography/computed tomography, and remains free of recurrent squamous cell carcinoma at 16 months following treatment. This case supports the use of combined chemoradiotherapy as a potential therapeutic option for patients with primary tracheal squamous cell carcinoma, and emphasises the challenges associated with the long-term management of recurrent respiratory papillomatosis. SAGE Publications 2021-10-21 /pmc/articles/PMC8543711/ /pubmed/34707869 http://dx.doi.org/10.1177/2050313X211054623 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Kovacs, Aaron C
Vodanovich, Domagoj
Mogridge, Emily K
Wun, Lisa
Corry, June
A case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy
title A case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy
title_full A case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy
title_fullStr A case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy
title_full_unstemmed A case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy
title_short A case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy
title_sort case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543711/
https://www.ncbi.nlm.nih.gov/pubmed/34707869
http://dx.doi.org/10.1177/2050313X211054623
work_keys_str_mv AT kovacsaaronc acaseofprimarytrachealsquamouscellcarcinomaarisingfrommalignanttransformationofrecurrentrespiratorypapillomatosiswithacompleteresponsetoconcurrentchemoradiotherapy
AT vodanovichdomagoj acaseofprimarytrachealsquamouscellcarcinomaarisingfrommalignanttransformationofrecurrentrespiratorypapillomatosiswithacompleteresponsetoconcurrentchemoradiotherapy
AT mogridgeemilyk acaseofprimarytrachealsquamouscellcarcinomaarisingfrommalignanttransformationofrecurrentrespiratorypapillomatosiswithacompleteresponsetoconcurrentchemoradiotherapy
AT wunlisa acaseofprimarytrachealsquamouscellcarcinomaarisingfrommalignanttransformationofrecurrentrespiratorypapillomatosiswithacompleteresponsetoconcurrentchemoradiotherapy
AT corryjune acaseofprimarytrachealsquamouscellcarcinomaarisingfrommalignanttransformationofrecurrentrespiratorypapillomatosiswithacompleteresponsetoconcurrentchemoradiotherapy
AT kovacsaaronc caseofprimarytrachealsquamouscellcarcinomaarisingfrommalignanttransformationofrecurrentrespiratorypapillomatosiswithacompleteresponsetoconcurrentchemoradiotherapy
AT vodanovichdomagoj caseofprimarytrachealsquamouscellcarcinomaarisingfrommalignanttransformationofrecurrentrespiratorypapillomatosiswithacompleteresponsetoconcurrentchemoradiotherapy
AT mogridgeemilyk caseofprimarytrachealsquamouscellcarcinomaarisingfrommalignanttransformationofrecurrentrespiratorypapillomatosiswithacompleteresponsetoconcurrentchemoradiotherapy
AT wunlisa caseofprimarytrachealsquamouscellcarcinomaarisingfrommalignanttransformationofrecurrentrespiratorypapillomatosiswithacompleteresponsetoconcurrentchemoradiotherapy
AT corryjune caseofprimarytrachealsquamouscellcarcinomaarisingfrommalignanttransformationofrecurrentrespiratorypapillomatosiswithacompleteresponsetoconcurrentchemoradiotherapy