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A case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy
Recurrent respiratory papillomatosis is a human papillomavirus-mediated condition characterised by the development of benign squamous papillomata of the respiratory tract. Malignant transformation of recurrent respiratory papillomatosis, while rare, carries a poor prognosis and there are limited dat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543711/ https://www.ncbi.nlm.nih.gov/pubmed/34707869 http://dx.doi.org/10.1177/2050313X211054623 |
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author | Kovacs, Aaron C Vodanovich, Domagoj Mogridge, Emily K Wun, Lisa Corry, June |
author_facet | Kovacs, Aaron C Vodanovich, Domagoj Mogridge, Emily K Wun, Lisa Corry, June |
author_sort | Kovacs, Aaron C |
collection | PubMed |
description | Recurrent respiratory papillomatosis is a human papillomavirus-mediated condition characterised by the development of benign squamous papillomata of the respiratory tract. Malignant transformation of recurrent respiratory papillomatosis, while rare, carries a poor prognosis and there are limited data surrounding treatment options, particularly in inoperable disease. We present the case of a 64-year-old male who developed malignant airway obstruction secondary to primary tracheal squamous cell carcinoma in the setting of a 5-year history of recurrent laryngotracheal papillomatosis, requiring placement of tracheostomy while on veno-venous extracorporeal membranous oxygenation. He was managed with cisplatin-based definitive chemoradiotherapy and had a complete metabolic response on post-treatment positron emission tomography/computed tomography, and remains free of recurrent squamous cell carcinoma at 16 months following treatment. This case supports the use of combined chemoradiotherapy as a potential therapeutic option for patients with primary tracheal squamous cell carcinoma, and emphasises the challenges associated with the long-term management of recurrent respiratory papillomatosis. |
format | Online Article Text |
id | pubmed-8543711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-85437112021-10-26 A case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy Kovacs, Aaron C Vodanovich, Domagoj Mogridge, Emily K Wun, Lisa Corry, June SAGE Open Med Case Rep Case Report Recurrent respiratory papillomatosis is a human papillomavirus-mediated condition characterised by the development of benign squamous papillomata of the respiratory tract. Malignant transformation of recurrent respiratory papillomatosis, while rare, carries a poor prognosis and there are limited data surrounding treatment options, particularly in inoperable disease. We present the case of a 64-year-old male who developed malignant airway obstruction secondary to primary tracheal squamous cell carcinoma in the setting of a 5-year history of recurrent laryngotracheal papillomatosis, requiring placement of tracheostomy while on veno-venous extracorporeal membranous oxygenation. He was managed with cisplatin-based definitive chemoradiotherapy and had a complete metabolic response on post-treatment positron emission tomography/computed tomography, and remains free of recurrent squamous cell carcinoma at 16 months following treatment. This case supports the use of combined chemoradiotherapy as a potential therapeutic option for patients with primary tracheal squamous cell carcinoma, and emphasises the challenges associated with the long-term management of recurrent respiratory papillomatosis. SAGE Publications 2021-10-21 /pmc/articles/PMC8543711/ /pubmed/34707869 http://dx.doi.org/10.1177/2050313X211054623 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Kovacs, Aaron C Vodanovich, Domagoj Mogridge, Emily K Wun, Lisa Corry, June A case of primary tracheal squamous cell carcinoma arising from malignant transformation of recurrent respiratory papillomatosis, with a complete response to concurrent chemoradiotherapy |
title | A case of primary tracheal squamous cell carcinoma arising from malignant
transformation of recurrent respiratory papillomatosis, with a complete response to
concurrent chemoradiotherapy |
title_full | A case of primary tracheal squamous cell carcinoma arising from malignant
transformation of recurrent respiratory papillomatosis, with a complete response to
concurrent chemoradiotherapy |
title_fullStr | A case of primary tracheal squamous cell carcinoma arising from malignant
transformation of recurrent respiratory papillomatosis, with a complete response to
concurrent chemoradiotherapy |
title_full_unstemmed | A case of primary tracheal squamous cell carcinoma arising from malignant
transformation of recurrent respiratory papillomatosis, with a complete response to
concurrent chemoradiotherapy |
title_short | A case of primary tracheal squamous cell carcinoma arising from malignant
transformation of recurrent respiratory papillomatosis, with a complete response to
concurrent chemoradiotherapy |
title_sort | case of primary tracheal squamous cell carcinoma arising from malignant
transformation of recurrent respiratory papillomatosis, with a complete response to
concurrent chemoradiotherapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543711/ https://www.ncbi.nlm.nih.gov/pubmed/34707869 http://dx.doi.org/10.1177/2050313X211054623 |
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