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Demographic, clinical, and laboratory factors associated with renal parenchymal injury in Iranian children with acute pyelonephritis
BACKGROUND: The association between renal parenchyma changes on dimercaptosuccinic acid (DMSA) scans and demographic, clinical, and laboratory markers was assessed in pediatric patients with acute pyelonephritis. METHODS: A retrospective study of 67 Iranian babies and children aged 1-month to 12-yea...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543838/ https://www.ncbi.nlm.nih.gov/pubmed/34689744 http://dx.doi.org/10.1186/s12879-021-06798-x |
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author | Fahimi, Daryoosh Khedmat, Leila Afshin, Azadeh Jafari, Mohsen Bakouei, Zakeyeh Beigi, Effat Hosseinali Kajiyazdi, Mohammad Izadi, Anahita Mojtahedi, Sayed Yousef |
author_facet | Fahimi, Daryoosh Khedmat, Leila Afshin, Azadeh Jafari, Mohsen Bakouei, Zakeyeh Beigi, Effat Hosseinali Kajiyazdi, Mohammad Izadi, Anahita Mojtahedi, Sayed Yousef |
author_sort | Fahimi, Daryoosh |
collection | PubMed |
description | BACKGROUND: The association between renal parenchyma changes on dimercaptosuccinic acid (DMSA) scans and demographic, clinical, and laboratory markers was assessed in pediatric patients with acute pyelonephritis. METHODS: A retrospective study of 67 Iranian babies and children aged 1-month to 12-year with APN was conducted between 2012 and 2018. The presence of renal parenchymal involvement (RPI) during APN was determined using technetium-99m DMSA during the first 2 weeks of hospitalization. The association of DMSA results with demographic data, clinical features (hospitalization stay, fever temperature and duration), and laboratory parameters such as pathogen type, and hematological factors (ESR, CRP, BUN, Cr, Hb, and WBC) was evaluated. RESULTS: 92.5% of children with an average age of 43.76 ± 5.2 months were girls. Twenty-four children (35.8%) did not have renal parenchymal injury (RPI), while 26 (38.8%) and 17 (25.4%) patients showed RPI in one and both kidneys, respectively. There was no significant association between RPI and mean ESR, CRP, BUN, and WBC. However, there were significant associations between RPI and higher mean levels of Cr, Hb, and BMI. CONCLUSIONS: Low BMI and Hb levels and increased Cr levels might be indicative of the presence of RPI in children with APN. |
format | Online Article Text |
id | pubmed-8543838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85438382021-10-25 Demographic, clinical, and laboratory factors associated with renal parenchymal injury in Iranian children with acute pyelonephritis Fahimi, Daryoosh Khedmat, Leila Afshin, Azadeh Jafari, Mohsen Bakouei, Zakeyeh Beigi, Effat Hosseinali Kajiyazdi, Mohammad Izadi, Anahita Mojtahedi, Sayed Yousef BMC Infect Dis Research Article BACKGROUND: The association between renal parenchyma changes on dimercaptosuccinic acid (DMSA) scans and demographic, clinical, and laboratory markers was assessed in pediatric patients with acute pyelonephritis. METHODS: A retrospective study of 67 Iranian babies and children aged 1-month to 12-year with APN was conducted between 2012 and 2018. The presence of renal parenchymal involvement (RPI) during APN was determined using technetium-99m DMSA during the first 2 weeks of hospitalization. The association of DMSA results with demographic data, clinical features (hospitalization stay, fever temperature and duration), and laboratory parameters such as pathogen type, and hematological factors (ESR, CRP, BUN, Cr, Hb, and WBC) was evaluated. RESULTS: 92.5% of children with an average age of 43.76 ± 5.2 months were girls. Twenty-four children (35.8%) did not have renal parenchymal injury (RPI), while 26 (38.8%) and 17 (25.4%) patients showed RPI in one and both kidneys, respectively. There was no significant association between RPI and mean ESR, CRP, BUN, and WBC. However, there were significant associations between RPI and higher mean levels of Cr, Hb, and BMI. CONCLUSIONS: Low BMI and Hb levels and increased Cr levels might be indicative of the presence of RPI in children with APN. BioMed Central 2021-10-24 /pmc/articles/PMC8543838/ /pubmed/34689744 http://dx.doi.org/10.1186/s12879-021-06798-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Fahimi, Daryoosh Khedmat, Leila Afshin, Azadeh Jafari, Mohsen Bakouei, Zakeyeh Beigi, Effat Hosseinali Kajiyazdi, Mohammad Izadi, Anahita Mojtahedi, Sayed Yousef Demographic, clinical, and laboratory factors associated with renal parenchymal injury in Iranian children with acute pyelonephritis |
title | Demographic, clinical, and laboratory factors associated with renal parenchymal injury in Iranian children with acute pyelonephritis |
title_full | Demographic, clinical, and laboratory factors associated with renal parenchymal injury in Iranian children with acute pyelonephritis |
title_fullStr | Demographic, clinical, and laboratory factors associated with renal parenchymal injury in Iranian children with acute pyelonephritis |
title_full_unstemmed | Demographic, clinical, and laboratory factors associated with renal parenchymal injury in Iranian children with acute pyelonephritis |
title_short | Demographic, clinical, and laboratory factors associated with renal parenchymal injury in Iranian children with acute pyelonephritis |
title_sort | demographic, clinical, and laboratory factors associated with renal parenchymal injury in iranian children with acute pyelonephritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543838/ https://www.ncbi.nlm.nih.gov/pubmed/34689744 http://dx.doi.org/10.1186/s12879-021-06798-x |
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