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Recent advances in selective photothermal therapy of tumor

Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways to improve the efficiency of tumor heat ablation to treat cancer, PTT may cause severe damage to normal tissue due to the...

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Autores principales: Zhao, Liping, Zhang, Xu, Wang, Xiaoxia, Guan, Xiuwen, Zhang, Weifeng, Ma, Jinlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543909/
https://www.ncbi.nlm.nih.gov/pubmed/34689765
http://dx.doi.org/10.1186/s12951-021-01080-3
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author Zhao, Liping
Zhang, Xu
Wang, Xiaoxia
Guan, Xiuwen
Zhang, Weifeng
Ma, Jinlong
author_facet Zhao, Liping
Zhang, Xu
Wang, Xiaoxia
Guan, Xiuwen
Zhang, Weifeng
Ma, Jinlong
author_sort Zhao, Liping
collection PubMed
description Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways to improve the efficiency of tumor heat ablation to treat cancer, PTT may cause severe damage to normal tissue due to the systemic distribution of photothermal agents (PTAs) in the body and inaccurate laser exposure during treatment. To further improve the survival rate of cancer patients and reduce possible side effects on other parts of the body, it is still necessary to explore PTAs with high selectivity and precise treatment. In this review, we summarized strategies to improve the treatment selectivity of PTT, such as increasing the accumulation of PTAs at tumor sites and endowing PTAs with a self-regulating photothermal conversion function. The views and challenges of selective PTT were discussed, especially the prospects and challenges of their clinical applications. [Image: see text]
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spelling pubmed-85439092021-10-25 Recent advances in selective photothermal therapy of tumor Zhao, Liping Zhang, Xu Wang, Xiaoxia Guan, Xiuwen Zhang, Weifeng Ma, Jinlong J Nanobiotechnology Review Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways to improve the efficiency of tumor heat ablation to treat cancer, PTT may cause severe damage to normal tissue due to the systemic distribution of photothermal agents (PTAs) in the body and inaccurate laser exposure during treatment. To further improve the survival rate of cancer patients and reduce possible side effects on other parts of the body, it is still necessary to explore PTAs with high selectivity and precise treatment. In this review, we summarized strategies to improve the treatment selectivity of PTT, such as increasing the accumulation of PTAs at tumor sites and endowing PTAs with a self-regulating photothermal conversion function. The views and challenges of selective PTT were discussed, especially the prospects and challenges of their clinical applications. [Image: see text] BioMed Central 2021-10-24 /pmc/articles/PMC8543909/ /pubmed/34689765 http://dx.doi.org/10.1186/s12951-021-01080-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhao, Liping
Zhang, Xu
Wang, Xiaoxia
Guan, Xiuwen
Zhang, Weifeng
Ma, Jinlong
Recent advances in selective photothermal therapy of tumor
title Recent advances in selective photothermal therapy of tumor
title_full Recent advances in selective photothermal therapy of tumor
title_fullStr Recent advances in selective photothermal therapy of tumor
title_full_unstemmed Recent advances in selective photothermal therapy of tumor
title_short Recent advances in selective photothermal therapy of tumor
title_sort recent advances in selective photothermal therapy of tumor
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543909/
https://www.ncbi.nlm.nih.gov/pubmed/34689765
http://dx.doi.org/10.1186/s12951-021-01080-3
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