PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population

BACKGROUND: Diabetes mellitus (DM) is a complex metabolic disease that is caused by a complex interplay between genetic and environmental factors. This research aimed to investigate the association of genetic polymorphisms in PDX1 and MC4R with T2DM risk. METHODS: The genotypes of 10 selected SNPs i...

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Autores principales: Wang, Ning, Tong, Rui, Xu, Jing, Tian, Yanni, Pan, Juan, Cui, Jiaqi, Chen, Huan, Peng, Yanqi, Fei, Sijia, Yang, Shujun, Wang, Lu, Yao, Juanchuan, Cui, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543917/
https://www.ncbi.nlm.nih.gov/pubmed/34696776
http://dx.doi.org/10.1186/s12920-021-01037-3
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author Wang, Ning
Tong, Rui
Xu, Jing
Tian, Yanni
Pan, Juan
Cui, Jiaqi
Chen, Huan
Peng, Yanqi
Fei, Sijia
Yang, Shujun
Wang, Lu
Yao, Juanchuan
Cui, Wei
author_facet Wang, Ning
Tong, Rui
Xu, Jing
Tian, Yanni
Pan, Juan
Cui, Jiaqi
Chen, Huan
Peng, Yanqi
Fei, Sijia
Yang, Shujun
Wang, Lu
Yao, Juanchuan
Cui, Wei
author_sort Wang, Ning
collection PubMed
description BACKGROUND: Diabetes mellitus (DM) is a complex metabolic disease that is caused by a complex interplay between genetic and environmental factors. This research aimed to investigate the association of genetic polymorphisms in PDX1 and MC4R with T2DM risk. METHODS: The genotypes of 10 selected SNPs in PDX1 and MC4R were identified using the Agena MassARRAY platform. We utilized odds ratio (OR) and 95% confidence intervals (CIs) to assess the correlation between genetic polymorphisms and T2DM risk. RESULTS: We found that PDX1-rs9581943 decreased susceptibility to T2DM among in a Chinese Han population (OR = 0.76, p = 0.045). We also found that selected genetic polymorphisms in PDX1 and MC4R could modify the risk of T2DM, which might also be influenced by age, sex, BMI, smoking status, and drinking status (p < 0.05). CONCLUSIONS: We concluded that PDX1 and MC4R genetic variants were significantly associated with T2DM risk in a Chinese Han population. These single polymorphic markers may be considered to be new targets in the assessment and prevention of T2DM among Chinese Han people. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-021-01037-3.
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spelling pubmed-85439172021-10-25 PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population Wang, Ning Tong, Rui Xu, Jing Tian, Yanni Pan, Juan Cui, Jiaqi Chen, Huan Peng, Yanqi Fei, Sijia Yang, Shujun Wang, Lu Yao, Juanchuan Cui, Wei BMC Med Genomics Research BACKGROUND: Diabetes mellitus (DM) is a complex metabolic disease that is caused by a complex interplay between genetic and environmental factors. This research aimed to investigate the association of genetic polymorphisms in PDX1 and MC4R with T2DM risk. METHODS: The genotypes of 10 selected SNPs in PDX1 and MC4R were identified using the Agena MassARRAY platform. We utilized odds ratio (OR) and 95% confidence intervals (CIs) to assess the correlation between genetic polymorphisms and T2DM risk. RESULTS: We found that PDX1-rs9581943 decreased susceptibility to T2DM among in a Chinese Han population (OR = 0.76, p = 0.045). We also found that selected genetic polymorphisms in PDX1 and MC4R could modify the risk of T2DM, which might also be influenced by age, sex, BMI, smoking status, and drinking status (p < 0.05). CONCLUSIONS: We concluded that PDX1 and MC4R genetic variants were significantly associated with T2DM risk in a Chinese Han population. These single polymorphic markers may be considered to be new targets in the assessment and prevention of T2DM among Chinese Han people. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-021-01037-3. BioMed Central 2021-10-25 /pmc/articles/PMC8543917/ /pubmed/34696776 http://dx.doi.org/10.1186/s12920-021-01037-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Ning
Tong, Rui
Xu, Jing
Tian, Yanni
Pan, Juan
Cui, Jiaqi
Chen, Huan
Peng, Yanqi
Fei, Sijia
Yang, Shujun
Wang, Lu
Yao, Juanchuan
Cui, Wei
PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population
title PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population
title_full PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population
title_fullStr PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population
title_full_unstemmed PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population
title_short PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population
title_sort pdx1 and mc4r genetic polymorphisms are associated with type 2 diabetes mellitus risk in the chinese han population
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543917/
https://www.ncbi.nlm.nih.gov/pubmed/34696776
http://dx.doi.org/10.1186/s12920-021-01037-3
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