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Structure-guided steric hindrance engineering of Bacillus badius phenylalanine dehydrogenase for efficient l-homophenylalanine synthesis

BACKGROUND: Direct reductive amination of prochiral 2-oxo-4-phenylbutyric acid (2-OPBA) catalyzed by phenylalanine dehydrogenase (PheDH) is highly attractive in the synthesis of the pharmaceutical chiral building block l-homophenylalanine (l-HPA) given that its sole expense is ammonia and that water...

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Detalles Bibliográficos
Autores principales:	Wu, Tao, Mu, Xiaoqing, Xue, Yuyan, Xu, Yan, Nie, Yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543943/ https://www.ncbi.nlm.nih.gov/pubmed/34689801 http://dx.doi.org/10.1186/s13068-021-02055-0

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