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Evaluation of corneal sensitivity in multiple sclerosis patients

PURPOSE: To measure the corneal sensitivity in patients with multiple sclerosis (MS), to compare it with normal values and to study its correlation with different disease characteristics. METHODS: Corneal sensitivity of 28 MS patients was compared to corneal sensitivity of 28 age- and gender-matched...

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Autores principales: Sukkarieh, Georges, Ghorayeb, Ralph, Issa, Mohamad, Koussa, Salam, Waked, Naji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544080/
https://www.ncbi.nlm.nih.gov/pubmed/34427235
http://dx.doi.org/10.4103/ijo.IJO_3052_20
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author Sukkarieh, Georges
Ghorayeb, Ralph
Issa, Mohamad
Koussa, Salam
Waked, Naji
author_facet Sukkarieh, Georges
Ghorayeb, Ralph
Issa, Mohamad
Koussa, Salam
Waked, Naji
author_sort Sukkarieh, Georges
collection PubMed
description PURPOSE: To measure the corneal sensitivity in patients with multiple sclerosis (MS), to compare it with normal values and to study its correlation with different disease characteristics. METHODS: Corneal sensitivity of 28 MS patients was compared to corneal sensitivity of 28 age- and gender-matched normal controls. Corneal sensitivity was measured using the Cochet-Bonnet esthesiometer and was correlated to the duration, type and severity indexes of the disease. RESULTS: Corneal sensitivity was comparable between both groups (P = 0.79). No statistically significant correlation was found between corneal sensitivity and the duration of MS (P = 0.55) nor the severity indexes of MS (expanded disability status scale [EDSS] P = 0.52, global multiple sclerosis severity score [MSSS] P = 0.64). Following subgroup analysis, only the primary progressive (PPMS) form of MS had a reduced corneal sensitivity with P = 0.023, while remittent-recurrent (RRMS), secondary progressive (SPMS), and clinically isolated (CIS) forms of MS did not have any reduction in the corneal sensitivity. “ROC curve analysis” showed an area under the curve of 0.48. CONCLUSION: In the exception of PPMS subtype, MS patients have similar corneal sensitivity in comparison to controls. Cochet-Bonnet esthesiometer does not seem to be a good diagnostic tool or a disease severity marker for patients with MS.
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spelling pubmed-85440802021-10-29 Evaluation of corneal sensitivity in multiple sclerosis patients Sukkarieh, Georges Ghorayeb, Ralph Issa, Mohamad Koussa, Salam Waked, Naji Indian J Ophthalmol Special Focus, Ocular Surface and Cornea, Original Article PURPOSE: To measure the corneal sensitivity in patients with multiple sclerosis (MS), to compare it with normal values and to study its correlation with different disease characteristics. METHODS: Corneal sensitivity of 28 MS patients was compared to corneal sensitivity of 28 age- and gender-matched normal controls. Corneal sensitivity was measured using the Cochet-Bonnet esthesiometer and was correlated to the duration, type and severity indexes of the disease. RESULTS: Corneal sensitivity was comparable between both groups (P = 0.79). No statistically significant correlation was found between corneal sensitivity and the duration of MS (P = 0.55) nor the severity indexes of MS (expanded disability status scale [EDSS] P = 0.52, global multiple sclerosis severity score [MSSS] P = 0.64). Following subgroup analysis, only the primary progressive (PPMS) form of MS had a reduced corneal sensitivity with P = 0.023, while remittent-recurrent (RRMS), secondary progressive (SPMS), and clinically isolated (CIS) forms of MS did not have any reduction in the corneal sensitivity. “ROC curve analysis” showed an area under the curve of 0.48. CONCLUSION: In the exception of PPMS subtype, MS patients have similar corneal sensitivity in comparison to controls. Cochet-Bonnet esthesiometer does not seem to be a good diagnostic tool or a disease severity marker for patients with MS. Wolters Kluwer - Medknow 2021-09 2021-08-25 /pmc/articles/PMC8544080/ /pubmed/34427235 http://dx.doi.org/10.4103/ijo.IJO_3052_20 Text en Copyright: © 2021 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Focus, Ocular Surface and Cornea, Original Article
Sukkarieh, Georges
Ghorayeb, Ralph
Issa, Mohamad
Koussa, Salam
Waked, Naji
Evaluation of corneal sensitivity in multiple sclerosis patients
title Evaluation of corneal sensitivity in multiple sclerosis patients
title_full Evaluation of corneal sensitivity in multiple sclerosis patients
title_fullStr Evaluation of corneal sensitivity in multiple sclerosis patients
title_full_unstemmed Evaluation of corneal sensitivity in multiple sclerosis patients
title_short Evaluation of corneal sensitivity in multiple sclerosis patients
title_sort evaluation of corneal sensitivity in multiple sclerosis patients
topic Special Focus, Ocular Surface and Cornea, Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544080/
https://www.ncbi.nlm.nih.gov/pubmed/34427235
http://dx.doi.org/10.4103/ijo.IJO_3052_20
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