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MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7)

A copper oxide/cerium oxide nanocomposite (CuO/CeO(2), NC) was synthesized via a novel method using a metal–organic framework as a precursor. This nanomaterial was characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), field emission scanning electron micro...

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Autores principales: Javad Farhangi, Mohammad, Es-haghi, Ali, Taghavizadeh Yazdi, Mohammad Ehsan, Rahdar, Abbas, Baino, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544372/
https://www.ncbi.nlm.nih.gov/pubmed/34698230
http://dx.doi.org/10.3390/jfb12040053
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author Javad Farhangi, Mohammad
Es-haghi, Ali
Taghavizadeh Yazdi, Mohammad Ehsan
Rahdar, Abbas
Baino, Francesco
author_facet Javad Farhangi, Mohammad
Es-haghi, Ali
Taghavizadeh Yazdi, Mohammad Ehsan
Rahdar, Abbas
Baino, Francesco
author_sort Javad Farhangi, Mohammad
collection PubMed
description A copper oxide/cerium oxide nanocomposite (CuO/CeO(2), NC) was synthesized via a novel method using a metal–organic framework as a precursor. This nanomaterial was characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), dynamic light scattering size analysis (DLS), and zeta potential. The PXRD showed the successful synthesis of the CuO/CeO(2) NC, in which the 2theta values of 35.55° (d = 2.52 Å, 100%) and 38.73° (d = 2.32 Å, 96%) revealed the existence of copper (II) oxide. FTIR analysis showed the CeO(2), hydroxyl groups, absorbed water, and some residual peaks. The solid phase analysis by FESEM and TEM images showed mean particle sizes of 49.18 ± 24.50 nm and 30.58 ± 26.40 nm, respectively, which were comparable with crystallite size (38.4 nm) obtained from PXRD, but it appears the CuO/CeO(2) NC was not evenly distributed and in some areas, showed it was highly agglomerated. The hydrodynamic size (750.5 nm) also showed the agglomeration of the CuO/CeO(2) NCs in the solution, which had a negatively charged surface. The CuO/CeO(2) NCs showed anti-proliferative activity against human breast cancer cell line (MCF-7) in a dose- and time-dependence way, while affecting normal cells less significantly.
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spelling pubmed-85443722021-10-26 MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7) Javad Farhangi, Mohammad Es-haghi, Ali Taghavizadeh Yazdi, Mohammad Ehsan Rahdar, Abbas Baino, Francesco J Funct Biomater Article A copper oxide/cerium oxide nanocomposite (CuO/CeO(2), NC) was synthesized via a novel method using a metal–organic framework as a precursor. This nanomaterial was characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), dynamic light scattering size analysis (DLS), and zeta potential. The PXRD showed the successful synthesis of the CuO/CeO(2) NC, in which the 2theta values of 35.55° (d = 2.52 Å, 100%) and 38.73° (d = 2.32 Å, 96%) revealed the existence of copper (II) oxide. FTIR analysis showed the CeO(2), hydroxyl groups, absorbed water, and some residual peaks. The solid phase analysis by FESEM and TEM images showed mean particle sizes of 49.18 ± 24.50 nm and 30.58 ± 26.40 nm, respectively, which were comparable with crystallite size (38.4 nm) obtained from PXRD, but it appears the CuO/CeO(2) NC was not evenly distributed and in some areas, showed it was highly agglomerated. The hydrodynamic size (750.5 nm) also showed the agglomeration of the CuO/CeO(2) NCs in the solution, which had a negatively charged surface. The CuO/CeO(2) NCs showed anti-proliferative activity against human breast cancer cell line (MCF-7) in a dose- and time-dependence way, while affecting normal cells less significantly. MDPI 2021-09-28 /pmc/articles/PMC8544372/ /pubmed/34698230 http://dx.doi.org/10.3390/jfb12040053 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Javad Farhangi, Mohammad
Es-haghi, Ali
Taghavizadeh Yazdi, Mohammad Ehsan
Rahdar, Abbas
Baino, Francesco
MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7)
title MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7)
title_full MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7)
title_fullStr MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7)
title_full_unstemmed MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7)
title_short MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7)
title_sort mof-mediated synthesis of cuo/ceo(2) composite nanoparticles: characterization and estimation of the cellular toxicity against breast cancer cell line (mcf-7)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544372/
https://www.ncbi.nlm.nih.gov/pubmed/34698230
http://dx.doi.org/10.3390/jfb12040053
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