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MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7)
A copper oxide/cerium oxide nanocomposite (CuO/CeO(2), NC) was synthesized via a novel method using a metal–organic framework as a precursor. This nanomaterial was characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), field emission scanning electron micro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544372/ https://www.ncbi.nlm.nih.gov/pubmed/34698230 http://dx.doi.org/10.3390/jfb12040053 |
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author | Javad Farhangi, Mohammad Es-haghi, Ali Taghavizadeh Yazdi, Mohammad Ehsan Rahdar, Abbas Baino, Francesco |
author_facet | Javad Farhangi, Mohammad Es-haghi, Ali Taghavizadeh Yazdi, Mohammad Ehsan Rahdar, Abbas Baino, Francesco |
author_sort | Javad Farhangi, Mohammad |
collection | PubMed |
description | A copper oxide/cerium oxide nanocomposite (CuO/CeO(2), NC) was synthesized via a novel method using a metal–organic framework as a precursor. This nanomaterial was characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), dynamic light scattering size analysis (DLS), and zeta potential. The PXRD showed the successful synthesis of the CuO/CeO(2) NC, in which the 2theta values of 35.55° (d = 2.52 Å, 100%) and 38.73° (d = 2.32 Å, 96%) revealed the existence of copper (II) oxide. FTIR analysis showed the CeO(2), hydroxyl groups, absorbed water, and some residual peaks. The solid phase analysis by FESEM and TEM images showed mean particle sizes of 49.18 ± 24.50 nm and 30.58 ± 26.40 nm, respectively, which were comparable with crystallite size (38.4 nm) obtained from PXRD, but it appears the CuO/CeO(2) NC was not evenly distributed and in some areas, showed it was highly agglomerated. The hydrodynamic size (750.5 nm) also showed the agglomeration of the CuO/CeO(2) NCs in the solution, which had a negatively charged surface. The CuO/CeO(2) NCs showed anti-proliferative activity against human breast cancer cell line (MCF-7) in a dose- and time-dependence way, while affecting normal cells less significantly. |
format | Online Article Text |
id | pubmed-8544372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85443722021-10-26 MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7) Javad Farhangi, Mohammad Es-haghi, Ali Taghavizadeh Yazdi, Mohammad Ehsan Rahdar, Abbas Baino, Francesco J Funct Biomater Article A copper oxide/cerium oxide nanocomposite (CuO/CeO(2), NC) was synthesized via a novel method using a metal–organic framework as a precursor. This nanomaterial was characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), dynamic light scattering size analysis (DLS), and zeta potential. The PXRD showed the successful synthesis of the CuO/CeO(2) NC, in which the 2theta values of 35.55° (d = 2.52 Å, 100%) and 38.73° (d = 2.32 Å, 96%) revealed the existence of copper (II) oxide. FTIR analysis showed the CeO(2), hydroxyl groups, absorbed water, and some residual peaks. The solid phase analysis by FESEM and TEM images showed mean particle sizes of 49.18 ± 24.50 nm and 30.58 ± 26.40 nm, respectively, which were comparable with crystallite size (38.4 nm) obtained from PXRD, but it appears the CuO/CeO(2) NC was not evenly distributed and in some areas, showed it was highly agglomerated. The hydrodynamic size (750.5 nm) also showed the agglomeration of the CuO/CeO(2) NCs in the solution, which had a negatively charged surface. The CuO/CeO(2) NCs showed anti-proliferative activity against human breast cancer cell line (MCF-7) in a dose- and time-dependence way, while affecting normal cells less significantly. MDPI 2021-09-28 /pmc/articles/PMC8544372/ /pubmed/34698230 http://dx.doi.org/10.3390/jfb12040053 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Javad Farhangi, Mohammad Es-haghi, Ali Taghavizadeh Yazdi, Mohammad Ehsan Rahdar, Abbas Baino, Francesco MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7) |
title | MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7) |
title_full | MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7) |
title_fullStr | MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7) |
title_full_unstemmed | MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7) |
title_short | MOF-Mediated Synthesis of CuO/CeO(2) Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7) |
title_sort | mof-mediated synthesis of cuo/ceo(2) composite nanoparticles: characterization and estimation of the cellular toxicity against breast cancer cell line (mcf-7) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544372/ https://www.ncbi.nlm.nih.gov/pubmed/34698230 http://dx.doi.org/10.3390/jfb12040053 |
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