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Theranostic Advances of Bionanomaterials against Gestational Diabetes Mellitus: A Preliminary Review
Gestational diabetes mellitus (GDM) is the most frequent complication during pregnancy. This complex disease is characterized by glucose intolerance and consequent hyperglycemia that begins or is first diagnosed in pregnancy, and affects almost 7% of pregnant women. Previous reports have shown that...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544389/ https://www.ncbi.nlm.nih.gov/pubmed/34698244 http://dx.doi.org/10.3390/jfb12040054 |
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author | Barani, Mahmood Sargazi, Saman Mohammadzadeh, Vahideh Rahdar, Abbas Pandey, Sadanand Jha, Niraj Kumar Gupta, Piyush Kumar Thakur, Vijay Kumar |
author_facet | Barani, Mahmood Sargazi, Saman Mohammadzadeh, Vahideh Rahdar, Abbas Pandey, Sadanand Jha, Niraj Kumar Gupta, Piyush Kumar Thakur, Vijay Kumar |
author_sort | Barani, Mahmood |
collection | PubMed |
description | Gestational diabetes mellitus (GDM) is the most frequent complication during pregnancy. This complex disease is characterized by glucose intolerance and consequent hyperglycemia that begins or is first diagnosed in pregnancy, and affects almost 7% of pregnant women. Previous reports have shown that GDM is associated with increased pregnancy complications and might cause abnormal fetal development. At present, treatments are not suitable for the prevention and management of these patients. As an alternative therapeutic opportunity and a leading scientific technique, nanotechnology has helped enlighten the health of these affected women. Theranostic nanomaterials with unique properties and small sizes (at least <100 nm in one of their dimensions) have been recently engineered for clinics and pharmaceutics. Reducing materials to the nanoscale has successfully changed their properties and enabled them to uniquely interact with cell biomolecules. Several biosensing methods have been developed to monitor glucose levels in GDM patients. Moreover, cerium oxide nanoparticles (NPs), selenium NPs, polymeric NPs, and drug-loaded NPs loaded with therapeutic agents have been used for GDM treatment. Still, there are some challenges associated with the detection limits and toxicity of such nanomaterials. This preliminary review covers the aspects from a fast-developing field to generating nanomaterials and their applications in GDM diagnosis and treatment. |
format | Online Article Text |
id | pubmed-8544389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85443892021-10-26 Theranostic Advances of Bionanomaterials against Gestational Diabetes Mellitus: A Preliminary Review Barani, Mahmood Sargazi, Saman Mohammadzadeh, Vahideh Rahdar, Abbas Pandey, Sadanand Jha, Niraj Kumar Gupta, Piyush Kumar Thakur, Vijay Kumar J Funct Biomater Review Gestational diabetes mellitus (GDM) is the most frequent complication during pregnancy. This complex disease is characterized by glucose intolerance and consequent hyperglycemia that begins or is first diagnosed in pregnancy, and affects almost 7% of pregnant women. Previous reports have shown that GDM is associated with increased pregnancy complications and might cause abnormal fetal development. At present, treatments are not suitable for the prevention and management of these patients. As an alternative therapeutic opportunity and a leading scientific technique, nanotechnology has helped enlighten the health of these affected women. Theranostic nanomaterials with unique properties and small sizes (at least <100 nm in one of their dimensions) have been recently engineered for clinics and pharmaceutics. Reducing materials to the nanoscale has successfully changed their properties and enabled them to uniquely interact with cell biomolecules. Several biosensing methods have been developed to monitor glucose levels in GDM patients. Moreover, cerium oxide nanoparticles (NPs), selenium NPs, polymeric NPs, and drug-loaded NPs loaded with therapeutic agents have been used for GDM treatment. Still, there are some challenges associated with the detection limits and toxicity of such nanomaterials. This preliminary review covers the aspects from a fast-developing field to generating nanomaterials and their applications in GDM diagnosis and treatment. MDPI 2021-09-28 /pmc/articles/PMC8544389/ /pubmed/34698244 http://dx.doi.org/10.3390/jfb12040054 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Barani, Mahmood Sargazi, Saman Mohammadzadeh, Vahideh Rahdar, Abbas Pandey, Sadanand Jha, Niraj Kumar Gupta, Piyush Kumar Thakur, Vijay Kumar Theranostic Advances of Bionanomaterials against Gestational Diabetes Mellitus: A Preliminary Review |
title | Theranostic Advances of Bionanomaterials against Gestational Diabetes Mellitus: A Preliminary Review |
title_full | Theranostic Advances of Bionanomaterials against Gestational Diabetes Mellitus: A Preliminary Review |
title_fullStr | Theranostic Advances of Bionanomaterials against Gestational Diabetes Mellitus: A Preliminary Review |
title_full_unstemmed | Theranostic Advances of Bionanomaterials against Gestational Diabetes Mellitus: A Preliminary Review |
title_short | Theranostic Advances of Bionanomaterials against Gestational Diabetes Mellitus: A Preliminary Review |
title_sort | theranostic advances of bionanomaterials against gestational diabetes mellitus: a preliminary review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544389/ https://www.ncbi.nlm.nih.gov/pubmed/34698244 http://dx.doi.org/10.3390/jfb12040054 |
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