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The First Thousand Days: Kidney Health and Beyond

The global burden of chronic kidney disease (CKD) is rising. A superior strategy to advance global kidney health is required to prevent and treat CKD early. Kidney development can be impacted during the first 1000 days of life by numerous factors, including malnutrition, maternal illness, exposure t...

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Detalles Bibliográficos
Autores principales: Hsu, Chien-Ning, Tain, You-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544398/
https://www.ncbi.nlm.nih.gov/pubmed/34683012
http://dx.doi.org/10.3390/healthcare9101332
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author Hsu, Chien-Ning
Tain, You-Lin
author_facet Hsu, Chien-Ning
Tain, You-Lin
author_sort Hsu, Chien-Ning
collection PubMed
description The global burden of chronic kidney disease (CKD) is rising. A superior strategy to advance global kidney health is required to prevent and treat CKD early. Kidney development can be impacted during the first 1000 days of life by numerous factors, including malnutrition, maternal illness, exposure to chemicals, substance abuse, medication use, infection, and exogenous stress. In the current review, we summarize environmental risk factors reported thus far in clinical and experimental studies relating to the programming of kidney disease, and systematize the knowledge on common mechanisms underlying renal programming. The aim of this review is to discuss the primary and secondary prevention actions for enhancing kidney health from pregnancy to age 2. The final task is to address the potential interventions to target renal programming through updating animal studies. Together, we can enhance the future of global kidney health in the first 1000 days of life.
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spelling pubmed-85443982021-10-26 The First Thousand Days: Kidney Health and Beyond Hsu, Chien-Ning Tain, You-Lin Healthcare (Basel) Review The global burden of chronic kidney disease (CKD) is rising. A superior strategy to advance global kidney health is required to prevent and treat CKD early. Kidney development can be impacted during the first 1000 days of life by numerous factors, including malnutrition, maternal illness, exposure to chemicals, substance abuse, medication use, infection, and exogenous stress. In the current review, we summarize environmental risk factors reported thus far in clinical and experimental studies relating to the programming of kidney disease, and systematize the knowledge on common mechanisms underlying renal programming. The aim of this review is to discuss the primary and secondary prevention actions for enhancing kidney health from pregnancy to age 2. The final task is to address the potential interventions to target renal programming through updating animal studies. Together, we can enhance the future of global kidney health in the first 1000 days of life. MDPI 2021-10-06 /pmc/articles/PMC8544398/ /pubmed/34683012 http://dx.doi.org/10.3390/healthcare9101332 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hsu, Chien-Ning
Tain, You-Lin
The First Thousand Days: Kidney Health and Beyond
title The First Thousand Days: Kidney Health and Beyond
title_full The First Thousand Days: Kidney Health and Beyond
title_fullStr The First Thousand Days: Kidney Health and Beyond
title_full_unstemmed The First Thousand Days: Kidney Health and Beyond
title_short The First Thousand Days: Kidney Health and Beyond
title_sort first thousand days: kidney health and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544398/
https://www.ncbi.nlm.nih.gov/pubmed/34683012
http://dx.doi.org/10.3390/healthcare9101332
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