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Polyamide/Poly(Amino Acid) Polymers for Drug Delivery
Polymers have always played a critical role in the development of novel drug delivery systems by providing the sustained, controlled and targeted release of both hydrophobic and hydrophilic drugs. Among the different polymers, polyamides or poly(amino acid)s exhibit distinct features such as good bi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544418/ https://www.ncbi.nlm.nih.gov/pubmed/34698184 http://dx.doi.org/10.3390/jfb12040058 |
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author | Boddu, Sai H. S. Bhagav, Prakash Karla, Pradeep K. Jacob, Shery Adatiya, Mansi D. Dhameliya, Tejas M. Ranch, Ketan M. Tiwari, Amit K. |
author_facet | Boddu, Sai H. S. Bhagav, Prakash Karla, Pradeep K. Jacob, Shery Adatiya, Mansi D. Dhameliya, Tejas M. Ranch, Ketan M. Tiwari, Amit K. |
author_sort | Boddu, Sai H. S. |
collection | PubMed |
description | Polymers have always played a critical role in the development of novel drug delivery systems by providing the sustained, controlled and targeted release of both hydrophobic and hydrophilic drugs. Among the different polymers, polyamides or poly(amino acid)s exhibit distinct features such as good biocompatibility, slow degradability and flexible physicochemical modification. The degradation rates of poly(amino acid)s are influenced by the hydrophilicity of the amino acids that make up the polymer. Poly(amino acid)s are extensively used in the formulation of chemotherapeutics to achieve selective delivery for an appropriate duration of time in order to lessen the drug-related side effects and increase the anti-tumor efficacy. This review highlights various poly(amino acid) polymers used in drug delivery along with new developments in their utility. A thorough discussion on anticancer agents incorporated into poly(amino acid) micellar systems that are under clinical evaluation is included. |
format | Online Article Text |
id | pubmed-8544418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85444182021-10-26 Polyamide/Poly(Amino Acid) Polymers for Drug Delivery Boddu, Sai H. S. Bhagav, Prakash Karla, Pradeep K. Jacob, Shery Adatiya, Mansi D. Dhameliya, Tejas M. Ranch, Ketan M. Tiwari, Amit K. J Funct Biomater Review Polymers have always played a critical role in the development of novel drug delivery systems by providing the sustained, controlled and targeted release of both hydrophobic and hydrophilic drugs. Among the different polymers, polyamides or poly(amino acid)s exhibit distinct features such as good biocompatibility, slow degradability and flexible physicochemical modification. The degradation rates of poly(amino acid)s are influenced by the hydrophilicity of the amino acids that make up the polymer. Poly(amino acid)s are extensively used in the formulation of chemotherapeutics to achieve selective delivery for an appropriate duration of time in order to lessen the drug-related side effects and increase the anti-tumor efficacy. This review highlights various poly(amino acid) polymers used in drug delivery along with new developments in their utility. A thorough discussion on anticancer agents incorporated into poly(amino acid) micellar systems that are under clinical evaluation is included. MDPI 2021-10-08 /pmc/articles/PMC8544418/ /pubmed/34698184 http://dx.doi.org/10.3390/jfb12040058 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Boddu, Sai H. S. Bhagav, Prakash Karla, Pradeep K. Jacob, Shery Adatiya, Mansi D. Dhameliya, Tejas M. Ranch, Ketan M. Tiwari, Amit K. Polyamide/Poly(Amino Acid) Polymers for Drug Delivery |
title | Polyamide/Poly(Amino Acid) Polymers for Drug Delivery |
title_full | Polyamide/Poly(Amino Acid) Polymers for Drug Delivery |
title_fullStr | Polyamide/Poly(Amino Acid) Polymers for Drug Delivery |
title_full_unstemmed | Polyamide/Poly(Amino Acid) Polymers for Drug Delivery |
title_short | Polyamide/Poly(Amino Acid) Polymers for Drug Delivery |
title_sort | polyamide/poly(amino acid) polymers for drug delivery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544418/ https://www.ncbi.nlm.nih.gov/pubmed/34698184 http://dx.doi.org/10.3390/jfb12040058 |
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