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A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature

Central precocious puberty (CPP) is a condition that causes early gonadotropin-dependent sexual development; CPP is idiopathic in girls in most cases, whereas more than 50% of boys have an identifiable etiology. We conducted a qualitative systematic review following the ENTREQ (enhancing transparenc...

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Autores principales: Rana, Roberta, Perrillo, Teresa, Santoro, Nicola, Ortolani, Federica, Messina, Raffaella, Resta, Mariachiara, Perrucci, Ilenia, Ingravallo, Giuseppe, Cazzato, Gerardo, Grassi, Massimo, Pesce, Sabino, Signorelli, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544465/
https://www.ncbi.nlm.nih.gov/pubmed/34698255
http://dx.doi.org/10.3390/neurolint13040053
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author Rana, Roberta
Perrillo, Teresa
Santoro, Nicola
Ortolani, Federica
Messina, Raffaella
Resta, Mariachiara
Perrucci, Ilenia
Ingravallo, Giuseppe
Cazzato, Gerardo
Grassi, Massimo
Pesce, Sabino
Signorelli, Francesco
author_facet Rana, Roberta
Perrillo, Teresa
Santoro, Nicola
Ortolani, Federica
Messina, Raffaella
Resta, Mariachiara
Perrucci, Ilenia
Ingravallo, Giuseppe
Cazzato, Gerardo
Grassi, Massimo
Pesce, Sabino
Signorelli, Francesco
author_sort Rana, Roberta
collection PubMed
description Central precocious puberty (CPP) is a condition that causes early gonadotropin-dependent sexual development; CPP is idiopathic in girls in most cases, whereas more than 50% of boys have an identifiable etiology. We conducted a qualitative systematic review following the ENTREQ (enhancing transparency in reporting the synthesis of qualitative research) framework. A search was made in MEDLINE/Pubmed and MeSH Database using the terms “precocious puberty” AND “brain tumor” OR “posterior fossa tumor” OR “cerebellar tumor” OR “infratentorial tumor”, identifying five cases of pediatric patients with infratentorial tumors and CPP and a case of cerebellar ganglioglioma without hypothalamic−pituitary−gonadal axis involvement and/or intracranial hypertension. Our work highlights the importance of a multidisciplinary approach and extensive central nervous system imaging for patients presenting with CPP in order to detect possible tumor association. Moreover, we believe that this manuscript could contribute to stimulate other research because the exact mechanism of CPP in infratentorial brain lesions has not been understood yet.
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spelling pubmed-85444652021-10-26 A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature Rana, Roberta Perrillo, Teresa Santoro, Nicola Ortolani, Federica Messina, Raffaella Resta, Mariachiara Perrucci, Ilenia Ingravallo, Giuseppe Cazzato, Gerardo Grassi, Massimo Pesce, Sabino Signorelli, Francesco Neurol Int Case Report Central precocious puberty (CPP) is a condition that causes early gonadotropin-dependent sexual development; CPP is idiopathic in girls in most cases, whereas more than 50% of boys have an identifiable etiology. We conducted a qualitative systematic review following the ENTREQ (enhancing transparency in reporting the synthesis of qualitative research) framework. A search was made in MEDLINE/Pubmed and MeSH Database using the terms “precocious puberty” AND “brain tumor” OR “posterior fossa tumor” OR “cerebellar tumor” OR “infratentorial tumor”, identifying five cases of pediatric patients with infratentorial tumors and CPP and a case of cerebellar ganglioglioma without hypothalamic−pituitary−gonadal axis involvement and/or intracranial hypertension. Our work highlights the importance of a multidisciplinary approach and extensive central nervous system imaging for patients presenting with CPP in order to detect possible tumor association. Moreover, we believe that this manuscript could contribute to stimulate other research because the exact mechanism of CPP in infratentorial brain lesions has not been understood yet. MDPI 2021-10-20 /pmc/articles/PMC8544465/ /pubmed/34698255 http://dx.doi.org/10.3390/neurolint13040053 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Rana, Roberta
Perrillo, Teresa
Santoro, Nicola
Ortolani, Federica
Messina, Raffaella
Resta, Mariachiara
Perrucci, Ilenia
Ingravallo, Giuseppe
Cazzato, Gerardo
Grassi, Massimo
Pesce, Sabino
Signorelli, Francesco
A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature
title A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature
title_full A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature
title_fullStr A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature
title_full_unstemmed A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature
title_short A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature
title_sort rare case of posterior fossa tumor and central precocious puberty: case presentation and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544465/
https://www.ncbi.nlm.nih.gov/pubmed/34698255
http://dx.doi.org/10.3390/neurolint13040053
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