Hyperlipidemia and Obesity’s Role in Immune Dysregulation Underlying the Severity of COVID-19 Infection

Obesity and hyperlipidemia are known to be risk factors for various pathological disorders, including various forms of infectious respiratory disease, including the current Coronavirus outbreak termed Coronavirus Disease 19 (COVID-19). This review studies the effects of hyperlipidemia and obesity on...

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Autores principales: Khatchadourian, Christopher, Sisliyan, Christina, Nguyen, Kevin, Poladian, Nicole, Tian, Qi, Tamjidi, Faraaz, Luong, Bao, Singh, Manpreet, Robison, Jeremiah, Venketaraman, Vishwanath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544571/
https://www.ncbi.nlm.nih.gov/pubmed/34698139
http://dx.doi.org/10.3390/clinpract11040085
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author Khatchadourian, Christopher
Sisliyan, Christina
Nguyen, Kevin
Poladian, Nicole
Tian, Qi
Tamjidi, Faraaz
Luong, Bao
Singh, Manpreet
Robison, Jeremiah
Venketaraman, Vishwanath
author_facet Khatchadourian, Christopher
Sisliyan, Christina
Nguyen, Kevin
Poladian, Nicole
Tian, Qi
Tamjidi, Faraaz
Luong, Bao
Singh, Manpreet
Robison, Jeremiah
Venketaraman, Vishwanath
author_sort Khatchadourian, Christopher
collection PubMed
description Obesity and hyperlipidemia are known to be risk factors for various pathological disorders, including various forms of infectious respiratory disease, including the current Coronavirus outbreak termed Coronavirus Disease 19 (COVID-19). This review studies the effects of hyperlipidemia and obesity on enhancing the inflammatory response seen in COVID-19 and potential therapeutic pathways related to these processes. In order to better understand the underlying processes of cytokine and chemokine-induced inflammation, we must further investigate the immunomodulatory effects of agents such as Vitamin D and the reduced form of glutathione as adjunctive therapies for COVID-19 disease.
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spelling pubmed-85445712021-10-26 Hyperlipidemia and Obesity’s Role in Immune Dysregulation Underlying the Severity of COVID-19 Infection Khatchadourian, Christopher Sisliyan, Christina Nguyen, Kevin Poladian, Nicole Tian, Qi Tamjidi, Faraaz Luong, Bao Singh, Manpreet Robison, Jeremiah Venketaraman, Vishwanath Clin Pract Brief Report Obesity and hyperlipidemia are known to be risk factors for various pathological disorders, including various forms of infectious respiratory disease, including the current Coronavirus outbreak termed Coronavirus Disease 19 (COVID-19). This review studies the effects of hyperlipidemia and obesity on enhancing the inflammatory response seen in COVID-19 and potential therapeutic pathways related to these processes. In order to better understand the underlying processes of cytokine and chemokine-induced inflammation, we must further investigate the immunomodulatory effects of agents such as Vitamin D and the reduced form of glutathione as adjunctive therapies for COVID-19 disease. MDPI 2021-09-22 /pmc/articles/PMC8544571/ /pubmed/34698139 http://dx.doi.org/10.3390/clinpract11040085 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Khatchadourian, Christopher
Sisliyan, Christina
Nguyen, Kevin
Poladian, Nicole
Tian, Qi
Tamjidi, Faraaz
Luong, Bao
Singh, Manpreet
Robison, Jeremiah
Venketaraman, Vishwanath
Hyperlipidemia and Obesity’s Role in Immune Dysregulation Underlying the Severity of COVID-19 Infection
title Hyperlipidemia and Obesity’s Role in Immune Dysregulation Underlying the Severity of COVID-19 Infection
title_full Hyperlipidemia and Obesity’s Role in Immune Dysregulation Underlying the Severity of COVID-19 Infection
title_fullStr Hyperlipidemia and Obesity’s Role in Immune Dysregulation Underlying the Severity of COVID-19 Infection
title_full_unstemmed Hyperlipidemia and Obesity’s Role in Immune Dysregulation Underlying the Severity of COVID-19 Infection
title_short Hyperlipidemia and Obesity’s Role in Immune Dysregulation Underlying the Severity of COVID-19 Infection
title_sort hyperlipidemia and obesity’s role in immune dysregulation underlying the severity of covid-19 infection
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544571/
https://www.ncbi.nlm.nih.gov/pubmed/34698139
http://dx.doi.org/10.3390/clinpract11040085
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