Portal Vein Thrombosis in a Patient With Methylenetetrahydrofolate Reductase Gene Mutation and Normal Homocysteine Levels

A 21-year-old male presented with chief complaints of abdominal pain, nausea, and vomiting and was found to have portal vein thrombosis (PVT) on computed tomography (CT) scan of the abdomen, which was redemonstrated on ultrasound. Thrombophilia workup was negative except that patient was heterozygou...

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Autores principales: Ghumman, Ghulam Mujtaba, Ishtiaq, Rizwan, Avasthi, Deepti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544635/
https://www.ncbi.nlm.nih.gov/pubmed/34722031
http://dx.doi.org/10.7759/cureus.18225
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author Ghumman, Ghulam Mujtaba
Ishtiaq, Rizwan
Avasthi, Deepti
author_facet Ghumman, Ghulam Mujtaba
Ishtiaq, Rizwan
Avasthi, Deepti
author_sort Ghumman, Ghulam Mujtaba
collection PubMed
description A 21-year-old male presented with chief complaints of abdominal pain, nausea, and vomiting and was found to have portal vein thrombosis (PVT) on computed tomography (CT) scan of the abdomen, which was redemonstrated on ultrasound. Thrombophilia workup was negative except that patient was heterozygous for methylenetetrahydrofolate reductase (MTHFR) gene mutation. Homocysteine levels were normal. The patient was started on enoxaparin and discharged on apixaban with the plan to continue anticoagulation for at least six months. Follow-up MRI after four months showed interval improvement of the main portal vein thrombus with the use of Eliquis.
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spelling pubmed-85446352021-10-28 Portal Vein Thrombosis in a Patient With Methylenetetrahydrofolate Reductase Gene Mutation and Normal Homocysteine Levels Ghumman, Ghulam Mujtaba Ishtiaq, Rizwan Avasthi, Deepti Cureus Genetics A 21-year-old male presented with chief complaints of abdominal pain, nausea, and vomiting and was found to have portal vein thrombosis (PVT) on computed tomography (CT) scan of the abdomen, which was redemonstrated on ultrasound. Thrombophilia workup was negative except that patient was heterozygous for methylenetetrahydrofolate reductase (MTHFR) gene mutation. Homocysteine levels were normal. The patient was started on enoxaparin and discharged on apixaban with the plan to continue anticoagulation for at least six months. Follow-up MRI after four months showed interval improvement of the main portal vein thrombus with the use of Eliquis. Cureus 2021-09-23 /pmc/articles/PMC8544635/ /pubmed/34722031 http://dx.doi.org/10.7759/cureus.18225 Text en Copyright © 2021, Ghumman et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Genetics
Ghumman, Ghulam Mujtaba
Ishtiaq, Rizwan
Avasthi, Deepti
Portal Vein Thrombosis in a Patient With Methylenetetrahydrofolate Reductase Gene Mutation and Normal Homocysteine Levels
title Portal Vein Thrombosis in a Patient With Methylenetetrahydrofolate Reductase Gene Mutation and Normal Homocysteine Levels
title_full Portal Vein Thrombosis in a Patient With Methylenetetrahydrofolate Reductase Gene Mutation and Normal Homocysteine Levels
title_fullStr Portal Vein Thrombosis in a Patient With Methylenetetrahydrofolate Reductase Gene Mutation and Normal Homocysteine Levels
title_full_unstemmed Portal Vein Thrombosis in a Patient With Methylenetetrahydrofolate Reductase Gene Mutation and Normal Homocysteine Levels
title_short Portal Vein Thrombosis in a Patient With Methylenetetrahydrofolate Reductase Gene Mutation and Normal Homocysteine Levels
title_sort portal vein thrombosis in a patient with methylenetetrahydrofolate reductase gene mutation and normal homocysteine levels
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544635/
https://www.ncbi.nlm.nih.gov/pubmed/34722031
http://dx.doi.org/10.7759/cureus.18225
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AT ishtiaqrizwan portalveinthrombosisinapatientwithmethylenetetrahydrofolatereductasegenemutationandnormalhomocysteinelevels
AT avasthideepti portalveinthrombosisinapatientwithmethylenetetrahydrofolatereductasegenemutationandnormalhomocysteinelevels

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