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Antimicrobial Resistance Situational Analysis 2019–2020: Design and Performance for Human Health Surveillance in Uganda

Antibiotic resistance and its mechanisms have been known for over six decades, but global efforts to characterize its routine drivers have only gained momentum in the recent past. Drivers of clinical and community resistance go beyond just clinical practice, which is why one-health approaches offer...

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Autores principales: Mugerwa, Ibrahimm, Nabadda, Susan N., Midega, Janet, Guma, Consolata, Kalyesubula, Simeon, Muwonge, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544686/
https://www.ncbi.nlm.nih.gov/pubmed/34698282
http://dx.doi.org/10.3390/tropicalmed6040178
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author Mugerwa, Ibrahimm
Nabadda, Susan N.
Midega, Janet
Guma, Consolata
Kalyesubula, Simeon
Muwonge, Adrian
author_facet Mugerwa, Ibrahimm
Nabadda, Susan N.
Midega, Janet
Guma, Consolata
Kalyesubula, Simeon
Muwonge, Adrian
author_sort Mugerwa, Ibrahimm
collection PubMed
description Antibiotic resistance and its mechanisms have been known for over six decades, but global efforts to characterize its routine drivers have only gained momentum in the recent past. Drivers of clinical and community resistance go beyond just clinical practice, which is why one-health approaches offer the most realistic option for controlling antibiotic resistance. It is noteworthy that the emergence of resistance occurs naturally in the environment, but akin to climate change, the current accelerated emergence and spread bears hallmarks of anthropomorphic influence. If left unchecked, this can undo the medical and agricultural advancements of the last century. The WHO recommends that nations develop, adopt, and implement strategies that track the changing trends in antibiotic resistance levels to tackle this problem. This article examines efforts and progress in developing and implementing a human health antimicrobial resistance surveillance strategy in Uganda. We do so within the context of the National Action Plan for tackling antimicrobial resistance (AMR-NAP) launched in 2018. We discuss the technical milestones and progress in implementing surveillance of GLASS priority pathogens under this framework. The preliminary output of the framework examines the performance and compares AMR and AMU surveillance data to explain observed trends. We conclude that Uganda is making progress in developing and implementing a functional AMR surveillance strategy for human health.
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spelling pubmed-85446862021-10-26 Antimicrobial Resistance Situational Analysis 2019–2020: Design and Performance for Human Health Surveillance in Uganda Mugerwa, Ibrahimm Nabadda, Susan N. Midega, Janet Guma, Consolata Kalyesubula, Simeon Muwonge, Adrian Trop Med Infect Dis Review Antibiotic resistance and its mechanisms have been known for over six decades, but global efforts to characterize its routine drivers have only gained momentum in the recent past. Drivers of clinical and community resistance go beyond just clinical practice, which is why one-health approaches offer the most realistic option for controlling antibiotic resistance. It is noteworthy that the emergence of resistance occurs naturally in the environment, but akin to climate change, the current accelerated emergence and spread bears hallmarks of anthropomorphic influence. If left unchecked, this can undo the medical and agricultural advancements of the last century. The WHO recommends that nations develop, adopt, and implement strategies that track the changing trends in antibiotic resistance levels to tackle this problem. This article examines efforts and progress in developing and implementing a human health antimicrobial resistance surveillance strategy in Uganda. We do so within the context of the National Action Plan for tackling antimicrobial resistance (AMR-NAP) launched in 2018. We discuss the technical milestones and progress in implementing surveillance of GLASS priority pathogens under this framework. The preliminary output of the framework examines the performance and compares AMR and AMU surveillance data to explain observed trends. We conclude that Uganda is making progress in developing and implementing a functional AMR surveillance strategy for human health. MDPI 2021-09-29 /pmc/articles/PMC8544686/ /pubmed/34698282 http://dx.doi.org/10.3390/tropicalmed6040178 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mugerwa, Ibrahimm
Nabadda, Susan N.
Midega, Janet
Guma, Consolata
Kalyesubula, Simeon
Muwonge, Adrian
Antimicrobial Resistance Situational Analysis 2019–2020: Design and Performance for Human Health Surveillance in Uganda
title Antimicrobial Resistance Situational Analysis 2019–2020: Design and Performance for Human Health Surveillance in Uganda
title_full Antimicrobial Resistance Situational Analysis 2019–2020: Design and Performance for Human Health Surveillance in Uganda
title_fullStr Antimicrobial Resistance Situational Analysis 2019–2020: Design and Performance for Human Health Surveillance in Uganda
title_full_unstemmed Antimicrobial Resistance Situational Analysis 2019–2020: Design and Performance for Human Health Surveillance in Uganda
title_short Antimicrobial Resistance Situational Analysis 2019–2020: Design and Performance for Human Health Surveillance in Uganda
title_sort antimicrobial resistance situational analysis 2019–2020: design and performance for human health surveillance in uganda
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544686/
https://www.ncbi.nlm.nih.gov/pubmed/34698282
http://dx.doi.org/10.3390/tropicalmed6040178
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