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SARS-CoV-2 in Conjunctiva and Tears and Ocular Symptoms of Patients with COVID-19
This study investigates the presence of SARS-CoV-2 in conjunctival secretions and tears and evaluates ocular symptoms in a group of patients with COVID-19. We included 56 hospitalized patients with COVID-19 in this cross-sectional cohort study. Conjunctival secretions and tears were collected using...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544743/ https://www.ncbi.nlm.nih.gov/pubmed/34698308 http://dx.doi.org/10.3390/vision5040051 |
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author | Rodríguez-Ares, Teresa Lamas-Francis, David Treviño, Mercedes Navarro, Daniel Cea, María López-Valladares, María Jesús Martínez, Laura Gude, Francisco Touriño, Rosario |
author_facet | Rodríguez-Ares, Teresa Lamas-Francis, David Treviño, Mercedes Navarro, Daniel Cea, María López-Valladares, María Jesús Martínez, Laura Gude, Francisco Touriño, Rosario |
author_sort | Rodríguez-Ares, Teresa |
collection | PubMed |
description | This study investigates the presence of SARS-CoV-2 in conjunctival secretions and tears and evaluates ocular symptoms in a group of patients with COVID-19. We included 56 hospitalized patients with COVID-19 in this cross-sectional cohort study. Conjunctival secretions and tears were collected using flocked swabs and Schirmer strips for SARS-CoV-2 reverse-transcriptase polymerase chain reaction (RT-PCR). Assessment of ocular surface manifestations included an OSDI (Ocular Surface Disease Index) questionnaire. Patients had been admitted to hospital for an average of 2.4 days (range 0–7) and had shown general symptoms for an average of 7.1 days (range 1–20) prior to ocular testing. Four (7.1%) of 56 conjunctival swabs and four (4%) of 112 Schirmer strips were positive for SARS-CoV-2. The mean E-gene cycle threshold values (Ct values) were 31.2 (SD 5.0) in conjunctival swabs and 32.9 (SD 2.7) in left eye Schirmer strips. Overall, 17 (30%) patients presented ocular symptoms. No association was found between positive ocular samples and ocular symptoms. This study shows that SARS-CoV-2 can be detected on the conjunctiva and tears of patients with COVID-19. Contact with the ocular surface may transmit the virus and preventive measures should be taken in this direction. |
format | Online Article Text |
id | pubmed-8544743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85447432021-10-26 SARS-CoV-2 in Conjunctiva and Tears and Ocular Symptoms of Patients with COVID-19 Rodríguez-Ares, Teresa Lamas-Francis, David Treviño, Mercedes Navarro, Daniel Cea, María López-Valladares, María Jesús Martínez, Laura Gude, Francisco Touriño, Rosario Vision (Basel) Communication This study investigates the presence of SARS-CoV-2 in conjunctival secretions and tears and evaluates ocular symptoms in a group of patients with COVID-19. We included 56 hospitalized patients with COVID-19 in this cross-sectional cohort study. Conjunctival secretions and tears were collected using flocked swabs and Schirmer strips for SARS-CoV-2 reverse-transcriptase polymerase chain reaction (RT-PCR). Assessment of ocular surface manifestations included an OSDI (Ocular Surface Disease Index) questionnaire. Patients had been admitted to hospital for an average of 2.4 days (range 0–7) and had shown general symptoms for an average of 7.1 days (range 1–20) prior to ocular testing. Four (7.1%) of 56 conjunctival swabs and four (4%) of 112 Schirmer strips were positive for SARS-CoV-2. The mean E-gene cycle threshold values (Ct values) were 31.2 (SD 5.0) in conjunctival swabs and 32.9 (SD 2.7) in left eye Schirmer strips. Overall, 17 (30%) patients presented ocular symptoms. No association was found between positive ocular samples and ocular symptoms. This study shows that SARS-CoV-2 can be detected on the conjunctiva and tears of patients with COVID-19. Contact with the ocular surface may transmit the virus and preventive measures should be taken in this direction. MDPI 2021-10-22 /pmc/articles/PMC8544743/ /pubmed/34698308 http://dx.doi.org/10.3390/vision5040051 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Rodríguez-Ares, Teresa Lamas-Francis, David Treviño, Mercedes Navarro, Daniel Cea, María López-Valladares, María Jesús Martínez, Laura Gude, Francisco Touriño, Rosario SARS-CoV-2 in Conjunctiva and Tears and Ocular Symptoms of Patients with COVID-19 |
title | SARS-CoV-2 in Conjunctiva and Tears and Ocular Symptoms of Patients with COVID-19 |
title_full | SARS-CoV-2 in Conjunctiva and Tears and Ocular Symptoms of Patients with COVID-19 |
title_fullStr | SARS-CoV-2 in Conjunctiva and Tears and Ocular Symptoms of Patients with COVID-19 |
title_full_unstemmed | SARS-CoV-2 in Conjunctiva and Tears and Ocular Symptoms of Patients with COVID-19 |
title_short | SARS-CoV-2 in Conjunctiva and Tears and Ocular Symptoms of Patients with COVID-19 |
title_sort | sars-cov-2 in conjunctiva and tears and ocular symptoms of patients with covid-19 |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544743/ https://www.ncbi.nlm.nih.gov/pubmed/34698308 http://dx.doi.org/10.3390/vision5040051 |
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