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Early stopping in clinical PET studies: How to reduce expense and exposure
Clinical positron emission tomography (PET) research is costly and entails exposing participants to radioactivity. Researchers should therefore aim to include just the number of subjects needed to fulfill the purpose of the study. In this tutorial we show how to apply sequential Bayes Factor testing...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545054/ https://www.ncbi.nlm.nih.gov/pubmed/34018825 http://dx.doi.org/10.1177/0271678X211017796 |
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author | Svensson, Jonas E Schain, Martin Knudsen, Gitte M Ogden, R Todd Plavén-Sigray, Pontus |
author_facet | Svensson, Jonas E Schain, Martin Knudsen, Gitte M Ogden, R Todd Plavén-Sigray, Pontus |
author_sort | Svensson, Jonas E |
collection | PubMed |
description | Clinical positron emission tomography (PET) research is costly and entails exposing participants to radioactivity. Researchers should therefore aim to include just the number of subjects needed to fulfill the purpose of the study. In this tutorial we show how to apply sequential Bayes Factor testing in order to stop the recruitment of subjects in a clinical PET study as soon as enough data have been collected to make a conclusion. By using simulations, we demonstrate that it is possible to stop a study early, while keeping the number of erroneous conclusions low. We then apply sequential Bayes Factor testing to a real PET data set and show that it is possible to obtain support in favor of an effect while simultaneously reducing the sample size with 30%. Using this procedure allows researchers to reduce expense and radioactivity exposure for a range of effect sizes relevant for PET research. |
format | Online Article Text |
id | pubmed-8545054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-85450542021-10-26 Early stopping in clinical PET studies: How to reduce expense and exposure Svensson, Jonas E Schain, Martin Knudsen, Gitte M Ogden, R Todd Plavén-Sigray, Pontus J Cereb Blood Flow Metab Review Articles Clinical positron emission tomography (PET) research is costly and entails exposing participants to radioactivity. Researchers should therefore aim to include just the number of subjects needed to fulfill the purpose of the study. In this tutorial we show how to apply sequential Bayes Factor testing in order to stop the recruitment of subjects in a clinical PET study as soon as enough data have been collected to make a conclusion. By using simulations, we demonstrate that it is possible to stop a study early, while keeping the number of erroneous conclusions low. We then apply sequential Bayes Factor testing to a real PET data set and show that it is possible to obtain support in favor of an effect while simultaneously reducing the sample size with 30%. Using this procedure allows researchers to reduce expense and radioactivity exposure for a range of effect sizes relevant for PET research. SAGE Publications 2021-05-21 2021-11 /pmc/articles/PMC8545054/ /pubmed/34018825 http://dx.doi.org/10.1177/0271678X211017796 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Articles Svensson, Jonas E Schain, Martin Knudsen, Gitte M Ogden, R Todd Plavén-Sigray, Pontus Early stopping in clinical PET studies: How to reduce expense and exposure |
title | Early stopping in clinical PET studies: How to reduce expense and exposure |
title_full | Early stopping in clinical PET studies: How to reduce expense and exposure |
title_fullStr | Early stopping in clinical PET studies: How to reduce expense and exposure |
title_full_unstemmed | Early stopping in clinical PET studies: How to reduce expense and exposure |
title_short | Early stopping in clinical PET studies: How to reduce expense and exposure |
title_sort | early stopping in clinical pet studies: how to reduce expense and exposure |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545054/ https://www.ncbi.nlm.nih.gov/pubmed/34018825 http://dx.doi.org/10.1177/0271678X211017796 |
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