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Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa

Multidrug-resistant (MDR) pathogens pose a significant public health threat. A major mechanism of resistance expressed by MDR pathogens is β-lactamase-mediated degradation of β-lactam antibiotics. The diazabicyclooctane (DBO) compounds zidebactam and WCK 5153, recognized as β-lactam “enhancers” due...

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Detalles Bibliográficos
Autores principales:	Rajavel, Malligarjunan, Kumar, Vijay, Nguyen, Ha, Wyatt, Jacob, Marshall, Steven H., Papp-Wallace, Krisztina M., Deshpande, Prasad, Bhavsar, Satish, Yeole, Ravindra, Bhagwat, Sachin, Patel, Mahesh, Bonomo, Robert A., van den Akker, Focco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545096/ https://www.ncbi.nlm.nih.gov/pubmed/33593978 http://dx.doi.org/10.1128/mBio.03058-20

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