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Sex-Specific Effects of Vitamin D Status on the Metabolic Profile in Prediabetic Subjects

INTRODUCTION: We aim to investigate the effect of vitamin D on metabolic parameters in a population with prediabetes and to detect possible sex differences. METHODS: In 621 patients with diagnosed prediabetes, glucose, lipid, and anthropometric parameters were measured. Furthermore, the interaction...

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Autores principales: Gisinger, Teresa, Leutner, Michael, Wohlschläger-Krenn, Evelyne, Winker, Robert, Nistler, Sonja, Endler, Georg, Kautzky-Willer, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545533/
https://www.ncbi.nlm.nih.gov/pubmed/34707658
http://dx.doi.org/10.1155/2021/2811756
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author Gisinger, Teresa
Leutner, Michael
Wohlschläger-Krenn, Evelyne
Winker, Robert
Nistler, Sonja
Endler, Georg
Kautzky-Willer, Alexandra
author_facet Gisinger, Teresa
Leutner, Michael
Wohlschläger-Krenn, Evelyne
Winker, Robert
Nistler, Sonja
Endler, Georg
Kautzky-Willer, Alexandra
author_sort Gisinger, Teresa
collection PubMed
description INTRODUCTION: We aim to investigate the effect of vitamin D on metabolic parameters in a population with prediabetes and to detect possible sex differences. METHODS: In 621 patients with diagnosed prediabetes, glucose, lipid, and anthropometric parameters were measured. Furthermore, the interaction of 25-OH-vitamin D (25-hydroxyvitamin D) with metabolic and glucose metabolism parameters was analysed in the total prediabetic population, as well as after stratification by sex (female vs. male prediabetic subgroup), by logistic regression. RESULTS: 25-OH-vitamin D was negatively related to cholesterol, BMI, fatty liver index, insulin, and HOMA-IR. Especially in the male prediabetic cohort, 25-OH-vitamin D levels negatively correlated with total cholesterol levels (r = −0.17, p=0.001), with triglycerides (r = −0.17, p=0.001), and with HbA1c levels (r = −0.14, p=0.010). Only in the female cohort with prediabetes, we found a negative correlation of 25-OH-vitamin D levels with systolic (r = −0.18, p=0.005) and diastolic blood pressures (r = −0.23, p < 0.001). CONCLUSION: In this study, in females with prediabetes, 25-OH-vitamin D was notably related to a more favourable metabolic profile, including lower total cholesterol and higher HDL cholesterol levels. On the contrary, in men with prediabetes, there was a stronger association between 25-OH-vitamin D and cholesterol-HDL quotient, as well as fatty liver index was observed in the male prediabetic subgroup. Therefore, sex differences should be considered in future studies on vitamin D and glucose tolerance status.
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spelling pubmed-85455332021-10-26 Sex-Specific Effects of Vitamin D Status on the Metabolic Profile in Prediabetic Subjects Gisinger, Teresa Leutner, Michael Wohlschläger-Krenn, Evelyne Winker, Robert Nistler, Sonja Endler, Georg Kautzky-Willer, Alexandra Int J Endocrinol Research Article INTRODUCTION: We aim to investigate the effect of vitamin D on metabolic parameters in a population with prediabetes and to detect possible sex differences. METHODS: In 621 patients with diagnosed prediabetes, glucose, lipid, and anthropometric parameters were measured. Furthermore, the interaction of 25-OH-vitamin D (25-hydroxyvitamin D) with metabolic and glucose metabolism parameters was analysed in the total prediabetic population, as well as after stratification by sex (female vs. male prediabetic subgroup), by logistic regression. RESULTS: 25-OH-vitamin D was negatively related to cholesterol, BMI, fatty liver index, insulin, and HOMA-IR. Especially in the male prediabetic cohort, 25-OH-vitamin D levels negatively correlated with total cholesterol levels (r = −0.17, p=0.001), with triglycerides (r = −0.17, p=0.001), and with HbA1c levels (r = −0.14, p=0.010). Only in the female cohort with prediabetes, we found a negative correlation of 25-OH-vitamin D levels with systolic (r = −0.18, p=0.005) and diastolic blood pressures (r = −0.23, p < 0.001). CONCLUSION: In this study, in females with prediabetes, 25-OH-vitamin D was notably related to a more favourable metabolic profile, including lower total cholesterol and higher HDL cholesterol levels. On the contrary, in men with prediabetes, there was a stronger association between 25-OH-vitamin D and cholesterol-HDL quotient, as well as fatty liver index was observed in the male prediabetic subgroup. Therefore, sex differences should be considered in future studies on vitamin D and glucose tolerance status. Hindawi 2021-10-05 /pmc/articles/PMC8545533/ /pubmed/34707658 http://dx.doi.org/10.1155/2021/2811756 Text en Copyright © 2021 Teresa Gisinger et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gisinger, Teresa
Leutner, Michael
Wohlschläger-Krenn, Evelyne
Winker, Robert
Nistler, Sonja
Endler, Georg
Kautzky-Willer, Alexandra
Sex-Specific Effects of Vitamin D Status on the Metabolic Profile in Prediabetic Subjects
title Sex-Specific Effects of Vitamin D Status on the Metabolic Profile in Prediabetic Subjects
title_full Sex-Specific Effects of Vitamin D Status on the Metabolic Profile in Prediabetic Subjects
title_fullStr Sex-Specific Effects of Vitamin D Status on the Metabolic Profile in Prediabetic Subjects
title_full_unstemmed Sex-Specific Effects of Vitamin D Status on the Metabolic Profile in Prediabetic Subjects
title_short Sex-Specific Effects of Vitamin D Status on the Metabolic Profile in Prediabetic Subjects
title_sort sex-specific effects of vitamin d status on the metabolic profile in prediabetic subjects
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545533/
https://www.ncbi.nlm.nih.gov/pubmed/34707658
http://dx.doi.org/10.1155/2021/2811756
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