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Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction

In this study, a chemical investigation on the fruits of Livistona chinensis (FLC) led to the isolation and identification of 45 polyphenols and 5 alkaloids, including two new compounds (Livischinol (1) and Livischinine A (46)), an undescribed compound (47) and 47 known compounds. FLC was predicted...

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Autores principales: Wang, Yuwei, Zhai, Jianxiu, Yang, Dan, Han, Na, Liu, Zhe, Liu, Zhihui, Li, Sikai, Yin, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545574/
https://www.ncbi.nlm.nih.gov/pubmed/34707780
http://dx.doi.org/10.1155/2021/7807046
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author Wang, Yuwei
Zhai, Jianxiu
Yang, Dan
Han, Na
Liu, Zhe
Liu, Zhihui
Li, Sikai
Yin, Jun
author_facet Wang, Yuwei
Zhai, Jianxiu
Yang, Dan
Han, Na
Liu, Zhe
Liu, Zhihui
Li, Sikai
Yin, Jun
author_sort Wang, Yuwei
collection PubMed
description In this study, a chemical investigation on the fruits of Livistona chinensis (FLC) led to the isolation and identification of 45 polyphenols and 5 alkaloids, including two new compounds (Livischinol (1) and Livischinine A (46)), an undescribed compound (47) and 47 known compounds. FLC was predicted with novel potential antidiabetic function by collecting and analyzing the potential targets of the ingredients. Compound 32 exhibited significant α-glucosidase inhibitory activity (IC(50) = 5.71 μM) and 1, 6, and 44 showed the PTP1B inhibitory activity with IC(50) values of 9.41-22.19 μM, while that of oleanolic acid was 28.58 μM. The competitive inhibitors of PTP1B (compounds 1 and 44) formed strong binding affinity, with catalytic active sites, proved by kinetic analysis, fluorescence spectra measurements, and computational simulations, and stimulated glucose uptake in the insulin-resistant HepG2 cells at the dose of 50 μM. In addition, FLC was rich in antioxidant and anti-inflammatory bioactive compounds so that they could be developed as nutraceuticals against diabetes.
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spelling pubmed-85455742021-10-26 Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction Wang, Yuwei Zhai, Jianxiu Yang, Dan Han, Na Liu, Zhe Liu, Zhihui Li, Sikai Yin, Jun Oxid Med Cell Longev Research Article In this study, a chemical investigation on the fruits of Livistona chinensis (FLC) led to the isolation and identification of 45 polyphenols and 5 alkaloids, including two new compounds (Livischinol (1) and Livischinine A (46)), an undescribed compound (47) and 47 known compounds. FLC was predicted with novel potential antidiabetic function by collecting and analyzing the potential targets of the ingredients. Compound 32 exhibited significant α-glucosidase inhibitory activity (IC(50) = 5.71 μM) and 1, 6, and 44 showed the PTP1B inhibitory activity with IC(50) values of 9.41-22.19 μM, while that of oleanolic acid was 28.58 μM. The competitive inhibitors of PTP1B (compounds 1 and 44) formed strong binding affinity, with catalytic active sites, proved by kinetic analysis, fluorescence spectra measurements, and computational simulations, and stimulated glucose uptake in the insulin-resistant HepG2 cells at the dose of 50 μM. In addition, FLC was rich in antioxidant and anti-inflammatory bioactive compounds so that they could be developed as nutraceuticals against diabetes. Hindawi 2021-10-18 /pmc/articles/PMC8545574/ /pubmed/34707780 http://dx.doi.org/10.1155/2021/7807046 Text en Copyright © 2021 Yuwei Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Yuwei
Zhai, Jianxiu
Yang, Dan
Han, Na
Liu, Zhe
Liu, Zhihui
Li, Sikai
Yin, Jun
Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction
title Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction
title_full Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction
title_fullStr Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction
title_full_unstemmed Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction
title_short Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction
title_sort antioxidant, anti-inflammatory, and antidiabetic activities of bioactive compounds from the fruits of livistona chinensis based on network pharmacology prediction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545574/
https://www.ncbi.nlm.nih.gov/pubmed/34707780
http://dx.doi.org/10.1155/2021/7807046
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