BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy

We herein report a rare case of BCR-ABL1-positive B-lymphoblastic lymphoma (B-LBL). An 18-year-old woman had a history of persistent left-sided chest pain. Positron emission tomography showed increased metabolic activity in the fifth rib, duodenum, and pancreas. The pathological findings of the panc...

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Autores principales: Yamada, Chika, Shimomura, Yoshimitsu, Kamijyo, Kimimori, Kanda-Kato, Madoka, Yoshioka, Satoshi, Yamashita, Daisuke, Ishikawa, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545644/
https://www.ncbi.nlm.nih.gov/pubmed/33814500
http://dx.doi.org/10.2169/internalmedicine.7066-21
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author Yamada, Chika
Shimomura, Yoshimitsu
Kamijyo, Kimimori
Kanda-Kato, Madoka
Yoshioka, Satoshi
Yamashita, Daisuke
Ishikawa, Takayuki
author_facet Yamada, Chika
Shimomura, Yoshimitsu
Kamijyo, Kimimori
Kanda-Kato, Madoka
Yoshioka, Satoshi
Yamashita, Daisuke
Ishikawa, Takayuki
author_sort Yamada, Chika
collection PubMed
description We herein report a rare case of BCR-ABL1-positive B-lymphoblastic lymphoma (B-LBL). An 18-year-old woman had a history of persistent left-sided chest pain. Positron emission tomography showed increased metabolic activity in the fifth rib, duodenum, and pancreas. The pathological findings of the pancreas, duodenum, and bone marrow confirmed the diagnosis of B-LBL. Polymerase chain reaction of duodenum and bone marrow also revealed a minor BCR-ABL1 fusion gene. She was diagnosed with BCR-ABL1-positive B-LBL and administered dasatinib and prednisolone. She achieved complete remission two weeks after the initiation of the treatment. She received stem cell transplantation after consolidation chemotherapy and sustained complete remission.
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spelling pubmed-85456442021-10-29 BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy Yamada, Chika Shimomura, Yoshimitsu Kamijyo, Kimimori Kanda-Kato, Madoka Yoshioka, Satoshi Yamashita, Daisuke Ishikawa, Takayuki Intern Med Case Report We herein report a rare case of BCR-ABL1-positive B-lymphoblastic lymphoma (B-LBL). An 18-year-old woman had a history of persistent left-sided chest pain. Positron emission tomography showed increased metabolic activity in the fifth rib, duodenum, and pancreas. The pathological findings of the pancreas, duodenum, and bone marrow confirmed the diagnosis of B-LBL. Polymerase chain reaction of duodenum and bone marrow also revealed a minor BCR-ABL1 fusion gene. She was diagnosed with BCR-ABL1-positive B-LBL and administered dasatinib and prednisolone. She achieved complete remission two weeks after the initiation of the treatment. She received stem cell transplantation after consolidation chemotherapy and sustained complete remission. The Japanese Society of Internal Medicine 2021-04-05 2021-10-01 /pmc/articles/PMC8545644/ /pubmed/33814500 http://dx.doi.org/10.2169/internalmedicine.7066-21 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yamada, Chika
Shimomura, Yoshimitsu
Kamijyo, Kimimori
Kanda-Kato, Madoka
Yoshioka, Satoshi
Yamashita, Daisuke
Ishikawa, Takayuki
BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy
title BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy
title_full BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy
title_fullStr BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy
title_full_unstemmed BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy
title_short BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy
title_sort bcr/abl1-positive b-lymphoblastic lymphoma successfully treated with dasatinib-combined chemotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545644/
https://www.ncbi.nlm.nih.gov/pubmed/33814500
http://dx.doi.org/10.2169/internalmedicine.7066-21
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