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EEG revealed improved vigilance regulation after stress exposure under Nx4 – A randomized, placebo-controlled, double-blind, cross-over trial
OBJECTIVES: Vigilance is characterized by alertness and sustained attention. The hyper-vigilance states are indicators of stress experience in the resting brain. Neurexan (Nx4) has been shown to modulate the neuroendocrine stress response. Here, we hypothesized that the intake of Nx4 would alter bra...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545679/ https://www.ncbi.nlm.nih.gov/pubmed/34729551 http://dx.doi.org/10.1016/j.ibneur.2021.09.002 |
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author | Chand, Tara Alizadeh, Sarah Jamalabadi, Hamidreza Herrmann, Luisa Krylova, Marina Surova, Galina van der Meer, Johan Wagner, Gred Engert, Veronika Walter, Martin |
author_facet | Chand, Tara Alizadeh, Sarah Jamalabadi, Hamidreza Herrmann, Luisa Krylova, Marina Surova, Galina van der Meer, Johan Wagner, Gred Engert, Veronika Walter, Martin |
author_sort | Chand, Tara |
collection | PubMed |
description | OBJECTIVES: Vigilance is characterized by alertness and sustained attention. The hyper-vigilance states are indicators of stress experience in the resting brain. Neurexan (Nx4) has been shown to modulate the neuroendocrine stress response. Here, we hypothesized that the intake of Nx4 would alter brain vigilance states at rest. METHOD: In this post-hoc analysis of the NEURIM study, EEG recordings of three, 12 min resting-state conditions in 39 healthy male volunteers were examined in a randomized, placebo-controlled, double-blind, cross-over clinical trial. EEG was recorded at three resting-state sessions: at baseline (RS0), after single-dose treatment with Nx4 or placebo (RS1), and subsequently after a psychosocial stress task (RS2). During each resting-state session, each 2-s segment of the consecutive EEG epochs was classified into one of seven different brain states along a wake-sleep continuum using the VIGALL 2.1 algorithm. RESULTS: In the post-stress resting-state, subjects exhibited a hyper-stable vigilance regulation characterized by an increase in the mean vigilance level and by more rigidity in the higher vigilance states for a longer period of time. Importantly, Nx4-treated participants exhibited significantly lower mean vigilance level compared to placebo-treated ones. Also, Nx4- compared to placebo-treated participants spent comparably less time in higher vigilance states and more time in lower vigilance states in the post-stress resting-state. CONCLUSION: Study participants showed a significantly lower mean vigilance level in the post-stress resting-state condition and tended to stay longer in lower vigilance states after treatment with Nx4. These findings support the known stress attenuation effect of Nx4. |
format | Online Article Text |
id | pubmed-8545679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-85456792021-11-01 EEG revealed improved vigilance regulation after stress exposure under Nx4 – A randomized, placebo-controlled, double-blind, cross-over trial Chand, Tara Alizadeh, Sarah Jamalabadi, Hamidreza Herrmann, Luisa Krylova, Marina Surova, Galina van der Meer, Johan Wagner, Gred Engert, Veronika Walter, Martin IBRO Neurosci Rep Research Paper OBJECTIVES: Vigilance is characterized by alertness and sustained attention. The hyper-vigilance states are indicators of stress experience in the resting brain. Neurexan (Nx4) has been shown to modulate the neuroendocrine stress response. Here, we hypothesized that the intake of Nx4 would alter brain vigilance states at rest. METHOD: In this post-hoc analysis of the NEURIM study, EEG recordings of three, 12 min resting-state conditions in 39 healthy male volunteers were examined in a randomized, placebo-controlled, double-blind, cross-over clinical trial. EEG was recorded at three resting-state sessions: at baseline (RS0), after single-dose treatment with Nx4 or placebo (RS1), and subsequently after a psychosocial stress task (RS2). During each resting-state session, each 2-s segment of the consecutive EEG epochs was classified into one of seven different brain states along a wake-sleep continuum using the VIGALL 2.1 algorithm. RESULTS: In the post-stress resting-state, subjects exhibited a hyper-stable vigilance regulation characterized by an increase in the mean vigilance level and by more rigidity in the higher vigilance states for a longer period of time. Importantly, Nx4-treated participants exhibited significantly lower mean vigilance level compared to placebo-treated ones. Also, Nx4- compared to placebo-treated participants spent comparably less time in higher vigilance states and more time in lower vigilance states in the post-stress resting-state. CONCLUSION: Study participants showed a significantly lower mean vigilance level in the post-stress resting-state condition and tended to stay longer in lower vigilance states after treatment with Nx4. These findings support the known stress attenuation effect of Nx4. Elsevier 2021-09-25 /pmc/articles/PMC8545679/ /pubmed/34729551 http://dx.doi.org/10.1016/j.ibneur.2021.09.002 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Paper Chand, Tara Alizadeh, Sarah Jamalabadi, Hamidreza Herrmann, Luisa Krylova, Marina Surova, Galina van der Meer, Johan Wagner, Gred Engert, Veronika Walter, Martin EEG revealed improved vigilance regulation after stress exposure under Nx4 – A randomized, placebo-controlled, double-blind, cross-over trial |
title | EEG revealed improved vigilance regulation after stress exposure under Nx4 – A randomized, placebo-controlled, double-blind, cross-over trial |
title_full | EEG revealed improved vigilance regulation after stress exposure under Nx4 – A randomized, placebo-controlled, double-blind, cross-over trial |
title_fullStr | EEG revealed improved vigilance regulation after stress exposure under Nx4 – A randomized, placebo-controlled, double-blind, cross-over trial |
title_full_unstemmed | EEG revealed improved vigilance regulation after stress exposure under Nx4 – A randomized, placebo-controlled, double-blind, cross-over trial |
title_short | EEG revealed improved vigilance regulation after stress exposure under Nx4 – A randomized, placebo-controlled, double-blind, cross-over trial |
title_sort | eeg revealed improved vigilance regulation after stress exposure under nx4 – a randomized, placebo-controlled, double-blind, cross-over trial |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545679/ https://www.ncbi.nlm.nih.gov/pubmed/34729551 http://dx.doi.org/10.1016/j.ibneur.2021.09.002 |
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