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Flipping the switch: How cysteine oxidation directs tau amyloid conformations
Tau can adopt distinct fibril conformations in different human neurodegenerative diseases, which may invoke distinct pathological mechanisms. In a recent issue, Weismiller et al. showed that intramolecular disulfide links between cys291 and cys322 for a specific tau isoform containing four microtubu...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Biochemistry and Molecular Biology
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545682/ https://www.ncbi.nlm.nih.gov/pubmed/34656563 http://dx.doi.org/10.1016/j.jbc.2021.101309 |