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P16(INK4a) Deletion Ameliorates Damage of Intestinal Epithelial Barrier and Microbial Dysbiosis in a Stress-Induced Premature Senescence Model of Bmi-1 Deficiency

This study aimed to determine whether Bmi-1 deficiency leads to intestinal epithelial barrier destruction and microbiota dysfunction, which members of the microbial community alter barrier function with age, and whether p16(INK4a) deletion could reverse the damage of intestinal epithelial barrier an...

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Detalles Bibliográficos
Autores principales:	Zhou, Jiawen, Hou, Chenxing, Chen, Haiyun, Qin, Ziyue, Miao, Zi’an, Zhao, Jingyu, Wang, Qiuyi, Cui, Min, Xie, Chunfeng, Wang, Rong, Li, Qing, Zuo, Guoping, Miao, Dengshun, Jin, Jianliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545785/ https://www.ncbi.nlm.nih.gov/pubmed/34712655 http://dx.doi.org/10.3389/fcell.2021.671564

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