Cargando…

Tuberculosis Outbreak in an Educational Institution in Henan Province, China

On June 17, 2018, a case of pulmonary tuberculosis (TB) was reported among students at a senior high school in Luoning, China. The outbreak encompassed a total of 23 cases along with TB screening in the whole school by means of PPD and chest X-ray. By the end of September 2018, the entire 9 cases cu...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Hui, Liu, Chunfa, Liang, Minghui, Liu, Dongxin, Zhao, Bing, Shi, Jie, Zhao, Yanlin, Ou, Xichao, Zhang, Guolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545879/
https://www.ncbi.nlm.nih.gov/pubmed/34712640
http://dx.doi.org/10.3389/fpubh.2021.737488
_version_ 1784590082977562624
author Li, Hui
Liu, Chunfa
Liang, Minghui
Liu, Dongxin
Zhao, Bing
Shi, Jie
Zhao, Yanlin
Ou, Xichao
Zhang, Guolong
author_facet Li, Hui
Liu, Chunfa
Liang, Minghui
Liu, Dongxin
Zhao, Bing
Shi, Jie
Zhao, Yanlin
Ou, Xichao
Zhang, Guolong
author_sort Li, Hui
collection PubMed
description On June 17, 2018, a case of pulmonary tuberculosis (TB) was reported among students at a senior high school in Luoning, China. The outbreak encompassed a total of 23 cases along with TB screening in the whole school by means of PPD and chest X-ray. By the end of September 2018, the entire 9 cases cultured positive had epidemiological association. All of the 9 Mycobacterium tuberculosis (Mtb) isolates available were sensitive to all drugs tested and had similar spoligotyping and 15 loci mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) profile. Whole-genome sequencing (WGS) of the Mtb isolates revealed 20 variable nucleotide positions within 8 cases, indicating a clonal outbreak. The index case, which was first identified and diagnosed, is separated from the cluster by a minimum number of 95 distinct SNPs. Minimum distance spanning tree (MST) indicted that the 8 cases were indeed part of a single transmission chain. It was concluded that this is an epidemic situation of TB outbreak exposed by the aggrieved index case at school, which was caused by the veiled infectious case wherein a student was suffering from TB and attending school simultaneously.
format Online
Article
Text
id pubmed-8545879
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85458792021-10-27 Tuberculosis Outbreak in an Educational Institution in Henan Province, China Li, Hui Liu, Chunfa Liang, Minghui Liu, Dongxin Zhao, Bing Shi, Jie Zhao, Yanlin Ou, Xichao Zhang, Guolong Front Public Health Public Health On June 17, 2018, a case of pulmonary tuberculosis (TB) was reported among students at a senior high school in Luoning, China. The outbreak encompassed a total of 23 cases along with TB screening in the whole school by means of PPD and chest X-ray. By the end of September 2018, the entire 9 cases cultured positive had epidemiological association. All of the 9 Mycobacterium tuberculosis (Mtb) isolates available were sensitive to all drugs tested and had similar spoligotyping and 15 loci mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) profile. Whole-genome sequencing (WGS) of the Mtb isolates revealed 20 variable nucleotide positions within 8 cases, indicating a clonal outbreak. The index case, which was first identified and diagnosed, is separated from the cluster by a minimum number of 95 distinct SNPs. Minimum distance spanning tree (MST) indicted that the 8 cases were indeed part of a single transmission chain. It was concluded that this is an epidemic situation of TB outbreak exposed by the aggrieved index case at school, which was caused by the veiled infectious case wherein a student was suffering from TB and attending school simultaneously. Frontiers Media S.A. 2021-10-12 /pmc/articles/PMC8545879/ /pubmed/34712640 http://dx.doi.org/10.3389/fpubh.2021.737488 Text en Copyright © 2021 Li, Liu, Liang, Liu, Zhao, Shi, Zhao, Ou and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Li, Hui
Liu, Chunfa
Liang, Minghui
Liu, Dongxin
Zhao, Bing
Shi, Jie
Zhao, Yanlin
Ou, Xichao
Zhang, Guolong
Tuberculosis Outbreak in an Educational Institution in Henan Province, China
title Tuberculosis Outbreak in an Educational Institution in Henan Province, China
title_full Tuberculosis Outbreak in an Educational Institution in Henan Province, China
title_fullStr Tuberculosis Outbreak in an Educational Institution in Henan Province, China
title_full_unstemmed Tuberculosis Outbreak in an Educational Institution in Henan Province, China
title_short Tuberculosis Outbreak in an Educational Institution in Henan Province, China
title_sort tuberculosis outbreak in an educational institution in henan province, china
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545879/
https://www.ncbi.nlm.nih.gov/pubmed/34712640
http://dx.doi.org/10.3389/fpubh.2021.737488
work_keys_str_mv AT lihui tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina
AT liuchunfa tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina
AT liangminghui tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina
AT liudongxin tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina
AT zhaobing tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina
AT shijie tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina
AT zhaoyanlin tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina
AT ouxichao tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina
AT zhangguolong tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina