Cargando…
Tuberculosis Outbreak in an Educational Institution in Henan Province, China
On June 17, 2018, a case of pulmonary tuberculosis (TB) was reported among students at a senior high school in Luoning, China. The outbreak encompassed a total of 23 cases along with TB screening in the whole school by means of PPD and chest X-ray. By the end of September 2018, the entire 9 cases cu...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545879/ https://www.ncbi.nlm.nih.gov/pubmed/34712640 http://dx.doi.org/10.3389/fpubh.2021.737488 |
_version_ | 1784590082977562624 |
---|---|
author | Li, Hui Liu, Chunfa Liang, Minghui Liu, Dongxin Zhao, Bing Shi, Jie Zhao, Yanlin Ou, Xichao Zhang, Guolong |
author_facet | Li, Hui Liu, Chunfa Liang, Minghui Liu, Dongxin Zhao, Bing Shi, Jie Zhao, Yanlin Ou, Xichao Zhang, Guolong |
author_sort | Li, Hui |
collection | PubMed |
description | On June 17, 2018, a case of pulmonary tuberculosis (TB) was reported among students at a senior high school in Luoning, China. The outbreak encompassed a total of 23 cases along with TB screening in the whole school by means of PPD and chest X-ray. By the end of September 2018, the entire 9 cases cultured positive had epidemiological association. All of the 9 Mycobacterium tuberculosis (Mtb) isolates available were sensitive to all drugs tested and had similar spoligotyping and 15 loci mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) profile. Whole-genome sequencing (WGS) of the Mtb isolates revealed 20 variable nucleotide positions within 8 cases, indicating a clonal outbreak. The index case, which was first identified and diagnosed, is separated from the cluster by a minimum number of 95 distinct SNPs. Minimum distance spanning tree (MST) indicted that the 8 cases were indeed part of a single transmission chain. It was concluded that this is an epidemic situation of TB outbreak exposed by the aggrieved index case at school, which was caused by the veiled infectious case wherein a student was suffering from TB and attending school simultaneously. |
format | Online Article Text |
id | pubmed-8545879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85458792021-10-27 Tuberculosis Outbreak in an Educational Institution in Henan Province, China Li, Hui Liu, Chunfa Liang, Minghui Liu, Dongxin Zhao, Bing Shi, Jie Zhao, Yanlin Ou, Xichao Zhang, Guolong Front Public Health Public Health On June 17, 2018, a case of pulmonary tuberculosis (TB) was reported among students at a senior high school in Luoning, China. The outbreak encompassed a total of 23 cases along with TB screening in the whole school by means of PPD and chest X-ray. By the end of September 2018, the entire 9 cases cultured positive had epidemiological association. All of the 9 Mycobacterium tuberculosis (Mtb) isolates available were sensitive to all drugs tested and had similar spoligotyping and 15 loci mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) profile. Whole-genome sequencing (WGS) of the Mtb isolates revealed 20 variable nucleotide positions within 8 cases, indicating a clonal outbreak. The index case, which was first identified and diagnosed, is separated from the cluster by a minimum number of 95 distinct SNPs. Minimum distance spanning tree (MST) indicted that the 8 cases were indeed part of a single transmission chain. It was concluded that this is an epidemic situation of TB outbreak exposed by the aggrieved index case at school, which was caused by the veiled infectious case wherein a student was suffering from TB and attending school simultaneously. Frontiers Media S.A. 2021-10-12 /pmc/articles/PMC8545879/ /pubmed/34712640 http://dx.doi.org/10.3389/fpubh.2021.737488 Text en Copyright © 2021 Li, Liu, Liang, Liu, Zhao, Shi, Zhao, Ou and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Li, Hui Liu, Chunfa Liang, Minghui Liu, Dongxin Zhao, Bing Shi, Jie Zhao, Yanlin Ou, Xichao Zhang, Guolong Tuberculosis Outbreak in an Educational Institution in Henan Province, China |
title | Tuberculosis Outbreak in an Educational Institution in Henan Province, China |
title_full | Tuberculosis Outbreak in an Educational Institution in Henan Province, China |
title_fullStr | Tuberculosis Outbreak in an Educational Institution in Henan Province, China |
title_full_unstemmed | Tuberculosis Outbreak in an Educational Institution in Henan Province, China |
title_short | Tuberculosis Outbreak in an Educational Institution in Henan Province, China |
title_sort | tuberculosis outbreak in an educational institution in henan province, china |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545879/ https://www.ncbi.nlm.nih.gov/pubmed/34712640 http://dx.doi.org/10.3389/fpubh.2021.737488 |
work_keys_str_mv | AT lihui tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina AT liuchunfa tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina AT liangminghui tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina AT liudongxin tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina AT zhaobing tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina AT shijie tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina AT zhaoyanlin tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina AT ouxichao tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina AT zhangguolong tuberculosisoutbreakinaneducationalinstitutioninhenanprovincechina |