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Application of Homograft Valved Conduit in Cardiac Surgery

Valved conduits often correct the blood flow of congenital heart disease by connecting the right ventricle to the pulmonary artery (RV-PA). The homograft valved conduit was invented in the 1960s, but its wide application is limited due to the lack of effective sterilization and preservation methods....

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Detalles Bibliográficos
Autores principales: Huyan, Yige, Chang, Yuan, Song, Jiangping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545902/
https://www.ncbi.nlm.nih.gov/pubmed/34712711
http://dx.doi.org/10.3389/fcvm.2021.740871
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author Huyan, Yige
Chang, Yuan
Song, Jiangping
author_facet Huyan, Yige
Chang, Yuan
Song, Jiangping
author_sort Huyan, Yige
collection PubMed
description Valved conduits often correct the blood flow of congenital heart disease by connecting the right ventricle to the pulmonary artery (RV-PA). The homograft valved conduit was invented in the 1960s, but its wide application is limited due to the lack of effective sterilization and preservation methods. Modern cryopreservation prolongs the preservation time of homograft valved conduit, which makes it become the most important treatment at present, and is widely used in Ross and other operations. However, homograft valved conduit has limited biocompatibility and durability and lacks any additional growth capacity. Therefore, decellularized valved conduit has been proposed as an effective improved method, which can reduce immune response and calcification, and has potential growth ability. In addition, as a possible substitute, commercial xenograft valved conduit has certain advantages in clinical application, and tissue engineering artificial valved conduit needs to be further studied.
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spelling pubmed-85459022021-10-27 Application of Homograft Valved Conduit in Cardiac Surgery Huyan, Yige Chang, Yuan Song, Jiangping Front Cardiovasc Med Cardiovascular Medicine Valved conduits often correct the blood flow of congenital heart disease by connecting the right ventricle to the pulmonary artery (RV-PA). The homograft valved conduit was invented in the 1960s, but its wide application is limited due to the lack of effective sterilization and preservation methods. Modern cryopreservation prolongs the preservation time of homograft valved conduit, which makes it become the most important treatment at present, and is widely used in Ross and other operations. However, homograft valved conduit has limited biocompatibility and durability and lacks any additional growth capacity. Therefore, decellularized valved conduit has been proposed as an effective improved method, which can reduce immune response and calcification, and has potential growth ability. In addition, as a possible substitute, commercial xenograft valved conduit has certain advantages in clinical application, and tissue engineering artificial valved conduit needs to be further studied. Frontiers Media S.A. 2021-10-12 /pmc/articles/PMC8545902/ /pubmed/34712711 http://dx.doi.org/10.3389/fcvm.2021.740871 Text en Copyright © 2021 Huyan, Chang and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Huyan, Yige
Chang, Yuan
Song, Jiangping
Application of Homograft Valved Conduit in Cardiac Surgery
title Application of Homograft Valved Conduit in Cardiac Surgery
title_full Application of Homograft Valved Conduit in Cardiac Surgery
title_fullStr Application of Homograft Valved Conduit in Cardiac Surgery
title_full_unstemmed Application of Homograft Valved Conduit in Cardiac Surgery
title_short Application of Homograft Valved Conduit in Cardiac Surgery
title_sort application of homograft valved conduit in cardiac surgery
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545902/
https://www.ncbi.nlm.nih.gov/pubmed/34712711
http://dx.doi.org/10.3389/fcvm.2021.740871
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