Cargando…
Application of Homograft Valved Conduit in Cardiac Surgery
Valved conduits often correct the blood flow of congenital heart disease by connecting the right ventricle to the pulmonary artery (RV-PA). The homograft valved conduit was invented in the 1960s, but its wide application is limited due to the lack of effective sterilization and preservation methods....
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545902/ https://www.ncbi.nlm.nih.gov/pubmed/34712711 http://dx.doi.org/10.3389/fcvm.2021.740871 |
_version_ | 1784590087964590080 |
---|---|
author | Huyan, Yige Chang, Yuan Song, Jiangping |
author_facet | Huyan, Yige Chang, Yuan Song, Jiangping |
author_sort | Huyan, Yige |
collection | PubMed |
description | Valved conduits often correct the blood flow of congenital heart disease by connecting the right ventricle to the pulmonary artery (RV-PA). The homograft valved conduit was invented in the 1960s, but its wide application is limited due to the lack of effective sterilization and preservation methods. Modern cryopreservation prolongs the preservation time of homograft valved conduit, which makes it become the most important treatment at present, and is widely used in Ross and other operations. However, homograft valved conduit has limited biocompatibility and durability and lacks any additional growth capacity. Therefore, decellularized valved conduit has been proposed as an effective improved method, which can reduce immune response and calcification, and has potential growth ability. In addition, as a possible substitute, commercial xenograft valved conduit has certain advantages in clinical application, and tissue engineering artificial valved conduit needs to be further studied. |
format | Online Article Text |
id | pubmed-8545902 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85459022021-10-27 Application of Homograft Valved Conduit in Cardiac Surgery Huyan, Yige Chang, Yuan Song, Jiangping Front Cardiovasc Med Cardiovascular Medicine Valved conduits often correct the blood flow of congenital heart disease by connecting the right ventricle to the pulmonary artery (RV-PA). The homograft valved conduit was invented in the 1960s, but its wide application is limited due to the lack of effective sterilization and preservation methods. Modern cryopreservation prolongs the preservation time of homograft valved conduit, which makes it become the most important treatment at present, and is widely used in Ross and other operations. However, homograft valved conduit has limited biocompatibility and durability and lacks any additional growth capacity. Therefore, decellularized valved conduit has been proposed as an effective improved method, which can reduce immune response and calcification, and has potential growth ability. In addition, as a possible substitute, commercial xenograft valved conduit has certain advantages in clinical application, and tissue engineering artificial valved conduit needs to be further studied. Frontiers Media S.A. 2021-10-12 /pmc/articles/PMC8545902/ /pubmed/34712711 http://dx.doi.org/10.3389/fcvm.2021.740871 Text en Copyright © 2021 Huyan, Chang and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Huyan, Yige Chang, Yuan Song, Jiangping Application of Homograft Valved Conduit in Cardiac Surgery |
title | Application of Homograft Valved Conduit in Cardiac Surgery |
title_full | Application of Homograft Valved Conduit in Cardiac Surgery |
title_fullStr | Application of Homograft Valved Conduit in Cardiac Surgery |
title_full_unstemmed | Application of Homograft Valved Conduit in Cardiac Surgery |
title_short | Application of Homograft Valved Conduit in Cardiac Surgery |
title_sort | application of homograft valved conduit in cardiac surgery |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545902/ https://www.ncbi.nlm.nih.gov/pubmed/34712711 http://dx.doi.org/10.3389/fcvm.2021.740871 |
work_keys_str_mv | AT huyanyige applicationofhomograftvalvedconduitincardiacsurgery AT changyuan applicationofhomograftvalvedconduitincardiacsurgery AT songjiangping applicationofhomograftvalvedconduitincardiacsurgery |