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Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke

Background: Atrial fibrillation (AF) is associated with high risk of stroke preventable by timely initiation of anticoagulation. Currently available screening tools based on ECG are not optimal due to inconvenience and high costs. Aim of this study was to study the diagnostic value of apelin for AF...

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Autores principales: Bohm, Allan, Snopek, Peter, Tothova, Lubomira, Bezak, Branislav, Jajcay, Nikola, Vachalcova, Marianna, Uher, Tomas, Kurecko, Marian, Kissova, Viera, Danova, Katarina, Olejnik, Peter, Michalek, Peter, Hlavata, Tereza, Petrikova, Katarina, Mojto, Viliam, Kyselovic, Jan, Farsky, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545982/
https://www.ncbi.nlm.nih.gov/pubmed/34712712
http://dx.doi.org/10.3389/fcvm.2021.742601
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author Bohm, Allan
Snopek, Peter
Tothova, Lubomira
Bezak, Branislav
Jajcay, Nikola
Vachalcova, Marianna
Uher, Tomas
Kurecko, Marian
Kissova, Viera
Danova, Katarina
Olejnik, Peter
Michalek, Peter
Hlavata, Tereza
Petrikova, Katarina
Mojto, Viliam
Kyselovic, Jan
Farsky, Stefan
author_facet Bohm, Allan
Snopek, Peter
Tothova, Lubomira
Bezak, Branislav
Jajcay, Nikola
Vachalcova, Marianna
Uher, Tomas
Kurecko, Marian
Kissova, Viera
Danova, Katarina
Olejnik, Peter
Michalek, Peter
Hlavata, Tereza
Petrikova, Katarina
Mojto, Viliam
Kyselovic, Jan
Farsky, Stefan
author_sort Bohm, Allan
collection PubMed
description Background: Atrial fibrillation (AF) is associated with high risk of stroke preventable by timely initiation of anticoagulation. Currently available screening tools based on ECG are not optimal due to inconvenience and high costs. Aim of this study was to study the diagnostic value of apelin for AF in patients with high risk of stroke. Methods: We designed a multicenter, matched-cohort study. The population consisted of three study groups: a healthy control group (34 patients) and two matched groups of 60 patients with high risk of stroke (AF and non-AF group). Apelin levels were examined from peripheral blood. Results: Apelin was significantly lower in AF group compared to non-AF group (0.694 ± 0.148 vs. 0.975 ± 0.458 ng/ml, p = 0.001) and control group (0.982 ± 0.060 ng/ml, p < 0.001), respectively. Receiver operating characteristic (ROC) analysis of apelin as a predictor of AF scored area under the curve (AUC) of 0.658. Apelin's concentration of 0.969 [ng/ml] had sensitivity = 0.966 and specificity = 0.467. Logistic regression based on manual feature selection showed that only apelin and NT-proBNP were independent predictors of AF. Logistic regression based on selection from bivariate analysis showed that only apelin was an independent predictor of AF. A logistic regression model using repeated stratified K-Fold cross-validation strategy scored an AUC of 0.725 ± 0.131. Conclusions: Our results suggest that apelin might be used to rule out AF in patients with high risk of stroke.
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spelling pubmed-85459822021-10-27 Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke Bohm, Allan Snopek, Peter Tothova, Lubomira Bezak, Branislav Jajcay, Nikola Vachalcova, Marianna Uher, Tomas Kurecko, Marian Kissova, Viera Danova, Katarina Olejnik, Peter Michalek, Peter Hlavata, Tereza Petrikova, Katarina Mojto, Viliam Kyselovic, Jan Farsky, Stefan Front Cardiovasc Med Cardiovascular Medicine Background: Atrial fibrillation (AF) is associated with high risk of stroke preventable by timely initiation of anticoagulation. Currently available screening tools based on ECG are not optimal due to inconvenience and high costs. Aim of this study was to study the diagnostic value of apelin for AF in patients with high risk of stroke. Methods: We designed a multicenter, matched-cohort study. The population consisted of three study groups: a healthy control group (34 patients) and two matched groups of 60 patients with high risk of stroke (AF and non-AF group). Apelin levels were examined from peripheral blood. Results: Apelin was significantly lower in AF group compared to non-AF group (0.694 ± 0.148 vs. 0.975 ± 0.458 ng/ml, p = 0.001) and control group (0.982 ± 0.060 ng/ml, p < 0.001), respectively. Receiver operating characteristic (ROC) analysis of apelin as a predictor of AF scored area under the curve (AUC) of 0.658. Apelin's concentration of 0.969 [ng/ml] had sensitivity = 0.966 and specificity = 0.467. Logistic regression based on manual feature selection showed that only apelin and NT-proBNP were independent predictors of AF. Logistic regression based on selection from bivariate analysis showed that only apelin was an independent predictor of AF. A logistic regression model using repeated stratified K-Fold cross-validation strategy scored an AUC of 0.725 ± 0.131. Conclusions: Our results suggest that apelin might be used to rule out AF in patients with high risk of stroke. Frontiers Media S.A. 2021-10-12 /pmc/articles/PMC8545982/ /pubmed/34712712 http://dx.doi.org/10.3389/fcvm.2021.742601 Text en Copyright © 2021 Bohm, Snopek, Tothova, Bezak, Jajcay, Vachalcova, Uher, Kurecko, Kissova, Danova, Olejnik, Michalek, Hlavata, Petrikova, Mojto, Kyselovic and Farsky. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Bohm, Allan
Snopek, Peter
Tothova, Lubomira
Bezak, Branislav
Jajcay, Nikola
Vachalcova, Marianna
Uher, Tomas
Kurecko, Marian
Kissova, Viera
Danova, Katarina
Olejnik, Peter
Michalek, Peter
Hlavata, Tereza
Petrikova, Katarina
Mojto, Viliam
Kyselovic, Jan
Farsky, Stefan
Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke
title Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke
title_full Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke
title_fullStr Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke
title_full_unstemmed Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke
title_short Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke
title_sort association between apelin and atrial fibrillation in patients with high risk of ischemic stroke
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545982/
https://www.ncbi.nlm.nih.gov/pubmed/34712712
http://dx.doi.org/10.3389/fcvm.2021.742601
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