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Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic

Recent studies demonstrated that domestic cats can be naturally and experimentally infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This study was performed to investigate the presence of SARS-CoV-2-specific antibodies within the domestic cat population in Istanbul, Turkey...

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Autores principales: Yilmaz, Aysun, Kayar, Abdullah, Turan, Nuri, Iskefli, Onur, Bayrakal, Alper, Roman-Sosa, Gleyder, Or, Erman, Tali, Hasan Emre, Kocazeybek, Bekir, Karaali, Ridvan, Bold, Dashzeveg, Sadeyen, Jean-Remy, Lukosaityte, Deimante, Chang, Pengxiang, Iqbal, Munir, Richt, Juergen A., Yilmaz, Huseyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545985/
https://www.ncbi.nlm.nih.gov/pubmed/34712718
http://dx.doi.org/10.3389/fvets.2021.707368
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author Yilmaz, Aysun
Kayar, Abdullah
Turan, Nuri
Iskefli, Onur
Bayrakal, Alper
Roman-Sosa, Gleyder
Or, Erman
Tali, Hasan Emre
Kocazeybek, Bekir
Karaali, Ridvan
Bold, Dashzeveg
Sadeyen, Jean-Remy
Lukosaityte, Deimante
Chang, Pengxiang
Iqbal, Munir
Richt, Juergen A.
Yilmaz, Huseyin
author_facet Yilmaz, Aysun
Kayar, Abdullah
Turan, Nuri
Iskefli, Onur
Bayrakal, Alper
Roman-Sosa, Gleyder
Or, Erman
Tali, Hasan Emre
Kocazeybek, Bekir
Karaali, Ridvan
Bold, Dashzeveg
Sadeyen, Jean-Remy
Lukosaityte, Deimante
Chang, Pengxiang
Iqbal, Munir
Richt, Juergen A.
Yilmaz, Huseyin
author_sort Yilmaz, Aysun
collection PubMed
description Recent studies demonstrated that domestic cats can be naturally and experimentally infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This study was performed to investigate the presence of SARS-CoV-2-specific antibodies within the domestic cat population in Istanbul, Turkey, before the coronavirus disease 2019 (COVID-19) and during the COVID-19 pandemic. Overall, from 155 cat sera analyzed, 26.45% (41/155) tested positive in the spike protein-ELISA (S-ELISA), 28.38% (44/155) in the receptor-binding domain-ELISA (RBD-ELISA), and 21.9% (34/155) in both, the S- and RBD-ELISAs. Twenty-seven of those were also positive for the presence of antibodies to feline coronavirus (FCoV). Among the 34 SARS-CoV-2-positive sera, three of those were positive on serum neutralization assay. Six of the 30 cats before COVID-19 and 28 of the 125 cats during COVID-19 were found to be seropositive. About 20% of ELISA-positive cats exhibited mainly respiratory, gastrointestinal, and renal signs and skin lesions. Hematocrit, hemoglobin, white blood cells, lymphocyte, and platelet numbers were low in about 30% of ELISA-positive cats. The number of neutrophils and monocytes were above normal values in about 20% of ELISA-positive cats. The liver enzyme alanine aminotransferase levels were high in 23.5% ELISA-positive cats. In conclusion, this is the first report describing antibodies specific to SARS-CoV-2 antigens (S and RBD) in cats in Istanbul, Turkey, indicating the risk for domestic cats to contract SARS-CoV-2 from owners and/or household members with COVID-19. This study and others show that COVID-19-positive pet owners should limit their contact with companion animals and that pets with respiratory signs should be monitored for SARS-CoV-2 infections.
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spelling pubmed-85459852021-10-27 Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic Yilmaz, Aysun Kayar, Abdullah Turan, Nuri Iskefli, Onur Bayrakal, Alper Roman-Sosa, Gleyder Or, Erman Tali, Hasan Emre Kocazeybek, Bekir Karaali, Ridvan Bold, Dashzeveg Sadeyen, Jean-Remy Lukosaityte, Deimante Chang, Pengxiang Iqbal, Munir Richt, Juergen A. Yilmaz, Huseyin Front Vet Sci Veterinary Science Recent studies demonstrated that domestic cats can be naturally and experimentally infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This study was performed to investigate the presence of SARS-CoV-2-specific antibodies within the domestic cat population in Istanbul, Turkey, before the coronavirus disease 2019 (COVID-19) and during the COVID-19 pandemic. Overall, from 155 cat sera analyzed, 26.45% (41/155) tested positive in the spike protein-ELISA (S-ELISA), 28.38% (44/155) in the receptor-binding domain-ELISA (RBD-ELISA), and 21.9% (34/155) in both, the S- and RBD-ELISAs. Twenty-seven of those were also positive for the presence of antibodies to feline coronavirus (FCoV). Among the 34 SARS-CoV-2-positive sera, three of those were positive on serum neutralization assay. Six of the 30 cats before COVID-19 and 28 of the 125 cats during COVID-19 were found to be seropositive. About 20% of ELISA-positive cats exhibited mainly respiratory, gastrointestinal, and renal signs and skin lesions. Hematocrit, hemoglobin, white blood cells, lymphocyte, and platelet numbers were low in about 30% of ELISA-positive cats. The number of neutrophils and monocytes were above normal values in about 20% of ELISA-positive cats. The liver enzyme alanine aminotransferase levels were high in 23.5% ELISA-positive cats. In conclusion, this is the first report describing antibodies specific to SARS-CoV-2 antigens (S and RBD) in cats in Istanbul, Turkey, indicating the risk for domestic cats to contract SARS-CoV-2 from owners and/or household members with COVID-19. This study and others show that COVID-19-positive pet owners should limit their contact with companion animals and that pets with respiratory signs should be monitored for SARS-CoV-2 infections. Frontiers Media S.A. 2021-10-12 /pmc/articles/PMC8545985/ /pubmed/34712718 http://dx.doi.org/10.3389/fvets.2021.707368 Text en Copyright © 2021 Yilmaz, Kayar, Turan, Iskefli, Bayrakal, Roman-Sosa, Or, Tali, Kocazeybek, Karaali, Bold, Sadeyen, Lukosaityte, Chang, Iqbal, Richt and Yilmaz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Yilmaz, Aysun
Kayar, Abdullah
Turan, Nuri
Iskefli, Onur
Bayrakal, Alper
Roman-Sosa, Gleyder
Or, Erman
Tali, Hasan Emre
Kocazeybek, Bekir
Karaali, Ridvan
Bold, Dashzeveg
Sadeyen, Jean-Remy
Lukosaityte, Deimante
Chang, Pengxiang
Iqbal, Munir
Richt, Juergen A.
Yilmaz, Huseyin
Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic
title Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic
title_full Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic
title_fullStr Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic
title_full_unstemmed Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic
title_short Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic
title_sort presence of antibodies to sars-cov-2 in domestic cats in istanbul, turkey, before and after covid-19 pandemic
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545985/
https://www.ncbi.nlm.nih.gov/pubmed/34712718
http://dx.doi.org/10.3389/fvets.2021.707368
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