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Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study

BACKGROUND: Microbubbles are widely used in diagnostic ultrasound applications as contrast agents. Recently, many studies have shown that microbubbles have good potential for the use in therapeutic applications such as drug and gene delivery and opening of blood- brain barrier locally and transientl...

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Autores principales: Khodabakhshi, Zahra, Hosseinkhah, Nazanin, Ghadiri, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546166/
https://www.ncbi.nlm.nih.gov/pubmed/34722408
http://dx.doi.org/10.31661/jbpe.v0i0.1131
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author Khodabakhshi, Zahra
Hosseinkhah, Nazanin
Ghadiri, Hossein
author_facet Khodabakhshi, Zahra
Hosseinkhah, Nazanin
Ghadiri, Hossein
author_sort Khodabakhshi, Zahra
collection PubMed
description BACKGROUND: Microbubbles are widely used in diagnostic ultrasound applications as contrast agents. Recently, many studies have shown that microbubbles have good potential for the use in therapeutic applications such as drug and gene delivery and opening of blood- brain barrier locally and transiently. When microbubbles are located inside an elastic microvessel and activated by ultrasound, they oscillate and induce mechanical stresses on the vessel wall. However, the mechanical stresses have beneficial therapeutic effects, they may induce vessel damage if they are too high. Microstreaming-induced shear stress is one of the most important wall stresses. OBJECTIVE: The overall aim of this study is to simulate the interaction between confined bubble inside an elastic microvessel and ultrasound field and investigate the effective parameters on microstreaming-induced shear stress. MATERIAL AND METHODS: In this Simulation study, we conducted a 2D finite element simulation to study confined microbubble dynamics, also we investigated both acoustical and bubble material parameters on microbubble oscillation and wall stress. RESULTS: Based on our results, for acoustic parameters in the range of therapeutic applications, the maximum shear stress was lower than 4 kPa. Shear stress was approximately independent from shell viscosity whereas it decreased by increasing the shell stiffness. Moreover, shear stress showed an increasing trend with acoustic pressure. CONCLUSION: Beside the acoustical parameters, bubble properties have important effects on bubble behavior so that the softer and larger bubbles are more appropriate for therapeutic application as they can decrease the required frequency and acoustic pressure while inducing the same biological effects.
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spelling pubmed-85461662021-10-29 Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study Khodabakhshi, Zahra Hosseinkhah, Nazanin Ghadiri, Hossein J Biomed Phys Eng Original Article BACKGROUND: Microbubbles are widely used in diagnostic ultrasound applications as contrast agents. Recently, many studies have shown that microbubbles have good potential for the use in therapeutic applications such as drug and gene delivery and opening of blood- brain barrier locally and transiently. When microbubbles are located inside an elastic microvessel and activated by ultrasound, they oscillate and induce mechanical stresses on the vessel wall. However, the mechanical stresses have beneficial therapeutic effects, they may induce vessel damage if they are too high. Microstreaming-induced shear stress is one of the most important wall stresses. OBJECTIVE: The overall aim of this study is to simulate the interaction between confined bubble inside an elastic microvessel and ultrasound field and investigate the effective parameters on microstreaming-induced shear stress. MATERIAL AND METHODS: In this Simulation study, we conducted a 2D finite element simulation to study confined microbubble dynamics, also we investigated both acoustical and bubble material parameters on microbubble oscillation and wall stress. RESULTS: Based on our results, for acoustic parameters in the range of therapeutic applications, the maximum shear stress was lower than 4 kPa. Shear stress was approximately independent from shell viscosity whereas it decreased by increasing the shell stiffness. Moreover, shear stress showed an increasing trend with acoustic pressure. CONCLUSION: Beside the acoustical parameters, bubble properties have important effects on bubble behavior so that the softer and larger bubbles are more appropriate for therapeutic application as they can decrease the required frequency and acoustic pressure while inducing the same biological effects. Shiraz University of Medical Sciences 2021-10-01 /pmc/articles/PMC8546166/ /pubmed/34722408 http://dx.doi.org/10.31661/jbpe.v0i0.1131 Text en Copyright: © Journal of Biomedical Physics and Engineering https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License, ( http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Khodabakhshi, Zahra
Hosseinkhah, Nazanin
Ghadiri, Hossein
Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study
title Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study
title_full Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study
title_fullStr Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study
title_full_unstemmed Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study
title_short Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study
title_sort pulsating microbubble in a micro-vessel and mechanical effect on vessel wall: a simulation study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546166/
https://www.ncbi.nlm.nih.gov/pubmed/34722408
http://dx.doi.org/10.31661/jbpe.v0i0.1131
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