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Dynamics of Intraprocedural Dominant Frequency Identifies Ablation Outcome in Persistent Atrial Fibrillation
Background: The role of dominant frequency (DF) in tracking the efficiency of a stepwise catheter ablation (step-CA) in persistent atrial fibrillation (peAF) remains poorly studied. We hypothesized that the DF time-course during step-CA displays divergent patterns between patients in whom a step-CA...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546232/ https://www.ncbi.nlm.nih.gov/pubmed/34712148 http://dx.doi.org/10.3389/fphys.2021.731917 |
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author | Pithon, Alain McCann, Anna Buttu, Andréa Vesin, Jean-Marc Pascale, Patrizio Le Bloa, Mathieu Herrera, Claudia Park, Chan-Il Roten, Laurent Kühne, Michael Spies, Florian Knecht, Sven Sticherling, Christian Pruvot, Etienne Luca, Adrian |
author_facet | Pithon, Alain McCann, Anna Buttu, Andréa Vesin, Jean-Marc Pascale, Patrizio Le Bloa, Mathieu Herrera, Claudia Park, Chan-Il Roten, Laurent Kühne, Michael Spies, Florian Knecht, Sven Sticherling, Christian Pruvot, Etienne Luca, Adrian |
author_sort | Pithon, Alain |
collection | PubMed |
description | Background: The role of dominant frequency (DF) in tracking the efficiency of a stepwise catheter ablation (step-CA) in persistent atrial fibrillation (peAF) remains poorly studied. We hypothesized that the DF time-course during step-CA displays divergent patterns between patients in whom a step-CA successfully restores long-term sinus rhythm (SR) and those with recurrence. Methods: This study involved 40 consecutive patients who underwent a step-CA for peAF (sustained duration 19 ± 11 months). Dominant frequency was computed on electrograms recorded from the right and left atrial appendages (RAA; LAA) and the coronary sinus before and during the step-CA synchronously to the 12-lead ECG. Dominant frequency was defined as the highest peak within the power spectrum. Results: Persistent atrial fibrillation was terminated by a step-CA in 28 patients [left-terminated (LT)], whereas 12 patients remaining in AF after ablation [not left-terminated (NLT)] were cardioverted. Over a mean follow-up of 34 ± 14 months, all NLT patients had a recurrence. Among the 28 LT patients, 20 had a recurrence, while 8 remained in SR throughout follow-up. The RAA and V(1) DF had the best predictive values of the procedural failure to terminate AF (area under the curve; AUC 0.84, p < 0.05). A decision tree model including a decrease in LAA DF ≥ 6.61% during the first 20 min following pulmonary vein isolation (PVI) and a baseline RAA DF <5.6 Hz predicted long-term SR restoration with a sensitivity of 83% and a specificity of 93% (p < 0.05). Conclusion: This study found that high baseline DF values are predictive of unfavorable ablation outcomes. The reduction of the LAA DF at early ablation steps following PVI is associated with procedural AF termination and long-term SR maintenance. |
format | Online Article Text |
id | pubmed-8546232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85462322021-10-27 Dynamics of Intraprocedural Dominant Frequency Identifies Ablation Outcome in Persistent Atrial Fibrillation Pithon, Alain McCann, Anna Buttu, Andréa Vesin, Jean-Marc Pascale, Patrizio Le Bloa, Mathieu Herrera, Claudia Park, Chan-Il Roten, Laurent Kühne, Michael Spies, Florian Knecht, Sven Sticherling, Christian Pruvot, Etienne Luca, Adrian Front Physiol Physiology Background: The role of dominant frequency (DF) in tracking the efficiency of a stepwise catheter ablation (step-CA) in persistent atrial fibrillation (peAF) remains poorly studied. We hypothesized that the DF time-course during step-CA displays divergent patterns between patients in whom a step-CA successfully restores long-term sinus rhythm (SR) and those with recurrence. Methods: This study involved 40 consecutive patients who underwent a step-CA for peAF (sustained duration 19 ± 11 months). Dominant frequency was computed on electrograms recorded from the right and left atrial appendages (RAA; LAA) and the coronary sinus before and during the step-CA synchronously to the 12-lead ECG. Dominant frequency was defined as the highest peak within the power spectrum. Results: Persistent atrial fibrillation was terminated by a step-CA in 28 patients [left-terminated (LT)], whereas 12 patients remaining in AF after ablation [not left-terminated (NLT)] were cardioverted. Over a mean follow-up of 34 ± 14 months, all NLT patients had a recurrence. Among the 28 LT patients, 20 had a recurrence, while 8 remained in SR throughout follow-up. The RAA and V(1) DF had the best predictive values of the procedural failure to terminate AF (area under the curve; AUC 0.84, p < 0.05). A decision tree model including a decrease in LAA DF ≥ 6.61% during the first 20 min following pulmonary vein isolation (PVI) and a baseline RAA DF <5.6 Hz predicted long-term SR restoration with a sensitivity of 83% and a specificity of 93% (p < 0.05). Conclusion: This study found that high baseline DF values are predictive of unfavorable ablation outcomes. The reduction of the LAA DF at early ablation steps following PVI is associated with procedural AF termination and long-term SR maintenance. Frontiers Media S.A. 2021-10-12 /pmc/articles/PMC8546232/ /pubmed/34712148 http://dx.doi.org/10.3389/fphys.2021.731917 Text en Copyright © 2021 Pithon, McCann, Buttu, Vesin, Pascale, Le Bloa, Herrera, Park, Roten, Kühne, Spies, Knecht, Sticherling, Pruvot and Luca. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Pithon, Alain McCann, Anna Buttu, Andréa Vesin, Jean-Marc Pascale, Patrizio Le Bloa, Mathieu Herrera, Claudia Park, Chan-Il Roten, Laurent Kühne, Michael Spies, Florian Knecht, Sven Sticherling, Christian Pruvot, Etienne Luca, Adrian Dynamics of Intraprocedural Dominant Frequency Identifies Ablation Outcome in Persistent Atrial Fibrillation |
title | Dynamics of Intraprocedural Dominant Frequency Identifies Ablation Outcome in Persistent Atrial Fibrillation |
title_full | Dynamics of Intraprocedural Dominant Frequency Identifies Ablation Outcome in Persistent Atrial Fibrillation |
title_fullStr | Dynamics of Intraprocedural Dominant Frequency Identifies Ablation Outcome in Persistent Atrial Fibrillation |
title_full_unstemmed | Dynamics of Intraprocedural Dominant Frequency Identifies Ablation Outcome in Persistent Atrial Fibrillation |
title_short | Dynamics of Intraprocedural Dominant Frequency Identifies Ablation Outcome in Persistent Atrial Fibrillation |
title_sort | dynamics of intraprocedural dominant frequency identifies ablation outcome in persistent atrial fibrillation |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546232/ https://www.ncbi.nlm.nih.gov/pubmed/34712148 http://dx.doi.org/10.3389/fphys.2021.731917 |
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