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Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency

BACKGROUND: Preclinical evidence implicates neutrophil elastase (NE) in pulmonary arterial hypertension (PAH) pathogenesis, and the NE inhibitor elafin is under early therapeutic investigation. RESEARCH QUESTION: Are circulating NE and elafin levels abnormal in PAH and are they associated with clini...

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Detalles Bibliográficos
Autores principales:	Sweatt, Andrew J., Miyagawa, Kazuya, Rhodes, Christopher J., Taylor, Shalina, Del Rosario, Patricia A., Hsi, Andrew, Haddad, Francois, Spiekerkoetter, Edda, Bental-Roof, Michal, Bland, Richard D., Swietlik, Emilia M., Gräf, Stefan, Wilkins, Martin R., Morrell, Nicholas W., Nicolls, Mark R., Rabinovitch, Marlene, Zamanian, Roham T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American College of Chest Physicians 2021
Materias:	Pulmonary Vascular: Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546243/ https://www.ncbi.nlm.nih.gov/pubmed/34181952 http://dx.doi.org/10.1016/j.chest.2021.06.028

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