Monitoring CAR T cell generation with a CD8-targeted lentiviral vector by single-cell transcriptomics

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Quantifying gene expression in individual cells can substantially improve our understanding about complex genetically engineered cell products such as chimeric antigen receptor (CAR) T cells. Here we designed a single-cell RNA sequencing (scRNA-seq) approach to monitor the delivery of a CD19-CAR gen...

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Detalles Bibliográficos
Autores principales: Charitidis, Filippos T., Adabi, Elham, Thalheimer, Frederic B., Clarke, Colin, Buchholz, Christian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546366/
https://www.ncbi.nlm.nih.gov/pubmed/34729382
http://dx.doi.org/10.1016/j.omtm.2021.09.019
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