Cargando…

Regulation of auditory plasticity during critical periods and following hearing loss

Sensory input has profound effects on neuronal organization and sensory maps in the brain. The mechanisms regulating plasticity of the auditory pathway have been revealed by examining the consequences of altered auditory input during both developmental critical periods—when plasticity facilitates th...

Descripción completa

Detalles Bibliográficos
Autores principales: Persic, Dora, Thomas, Maryse E., Pelekanos, Vassilis, Ryugo, David K., Takesian, Anne E., Krumbholz, Katrin, Pyott, Sonja J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546402/
https://www.ncbi.nlm.nih.gov/pubmed/32591097
http://dx.doi.org/10.1016/j.heares.2020.107976
_version_ 1784590189140639744
author Persic, Dora
Thomas, Maryse E.
Pelekanos, Vassilis
Ryugo, David K.
Takesian, Anne E.
Krumbholz, Katrin
Pyott, Sonja J.
author_facet Persic, Dora
Thomas, Maryse E.
Pelekanos, Vassilis
Ryugo, David K.
Takesian, Anne E.
Krumbholz, Katrin
Pyott, Sonja J.
author_sort Persic, Dora
collection PubMed
description Sensory input has profound effects on neuronal organization and sensory maps in the brain. The mechanisms regulating plasticity of the auditory pathway have been revealed by examining the consequences of altered auditory input during both developmental critical periods—when plasticity facilitates the optimization of neural circuits in concert with the external environment—and in adulthood—when hearing loss is linked to the generation of tinnitus. In this review, we summarize research identifying the molecular, cellular, and circuit-level mechanisms regulating neuronal organization and tonotopic map plasticity during developmental critical periods and in adulthood. These mechanisms are shared in both the juvenile and adult brain and along the length of the auditory pathway, where they serve to regulate disinhibitory networks, synaptic structure and function, as well as structural barriers to plasticity. Regulation of plasticity also involves both neuromodulatory circuits, which link plasticity with learning and attention, as well as ascending and descending auditory circuits, which link the auditory cortex and lower structures. Further work identifying the interplay of molecular and cellular mechanisms associating hearing loss-induced plasticity with tinnitus will continue to advance our understanding of this disorder and lead to new approaches to its treatment.
format Online
Article
Text
id pubmed-8546402
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier/North-Holland Biomedical Press
record_format MEDLINE/PubMed
spelling pubmed-85464022021-10-29 Regulation of auditory plasticity during critical periods and following hearing loss Persic, Dora Thomas, Maryse E. Pelekanos, Vassilis Ryugo, David K. Takesian, Anne E. Krumbholz, Katrin Pyott, Sonja J. Hear Res Review Article Sensory input has profound effects on neuronal organization and sensory maps in the brain. The mechanisms regulating plasticity of the auditory pathway have been revealed by examining the consequences of altered auditory input during both developmental critical periods—when plasticity facilitates the optimization of neural circuits in concert with the external environment—and in adulthood—when hearing loss is linked to the generation of tinnitus. In this review, we summarize research identifying the molecular, cellular, and circuit-level mechanisms regulating neuronal organization and tonotopic map plasticity during developmental critical periods and in adulthood. These mechanisms are shared in both the juvenile and adult brain and along the length of the auditory pathway, where they serve to regulate disinhibitory networks, synaptic structure and function, as well as structural barriers to plasticity. Regulation of plasticity also involves both neuromodulatory circuits, which link plasticity with learning and attention, as well as ascending and descending auditory circuits, which link the auditory cortex and lower structures. Further work identifying the interplay of molecular and cellular mechanisms associating hearing loss-induced plasticity with tinnitus will continue to advance our understanding of this disorder and lead to new approaches to its treatment. Elsevier/North-Holland Biomedical Press 2020-11 /pmc/articles/PMC8546402/ /pubmed/32591097 http://dx.doi.org/10.1016/j.heares.2020.107976 Text en Crown Copyright © 2020 Published by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Persic, Dora
Thomas, Maryse E.
Pelekanos, Vassilis
Ryugo, David K.
Takesian, Anne E.
Krumbholz, Katrin
Pyott, Sonja J.
Regulation of auditory plasticity during critical periods and following hearing loss
title Regulation of auditory plasticity during critical periods and following hearing loss
title_full Regulation of auditory plasticity during critical periods and following hearing loss
title_fullStr Regulation of auditory plasticity during critical periods and following hearing loss
title_full_unstemmed Regulation of auditory plasticity during critical periods and following hearing loss
title_short Regulation of auditory plasticity during critical periods and following hearing loss
title_sort regulation of auditory plasticity during critical periods and following hearing loss
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546402/
https://www.ncbi.nlm.nih.gov/pubmed/32591097
http://dx.doi.org/10.1016/j.heares.2020.107976
work_keys_str_mv AT persicdora regulationofauditoryplasticityduringcriticalperiodsandfollowinghearingloss
AT thomasmarysee regulationofauditoryplasticityduringcriticalperiodsandfollowinghearingloss
AT pelekanosvassilis regulationofauditoryplasticityduringcriticalperiodsandfollowinghearingloss
AT ryugodavidk regulationofauditoryplasticityduringcriticalperiodsandfollowinghearingloss
AT takesianannee regulationofauditoryplasticityduringcriticalperiodsandfollowinghearingloss
AT krumbholzkatrin regulationofauditoryplasticityduringcriticalperiodsandfollowinghearingloss
AT pyottsonjaj regulationofauditoryplasticityduringcriticalperiodsandfollowinghearingloss