Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells

BACKGROUND: Senescent cells accumulate in tissues over time as part of the natural ageing process and the removal of senescent cells has shown promise for alleviating many different age-related diseases in mice. Cancer is an age-associated disease and there are numerous mechanisms driving cellular s...

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Detalles Bibliográficos
Autores principales: Le, Hillary H., Cinaroglu, Suleyman S., Manalo, Elise C., Ors, Aysegul, Gomes, Michelle M., Duan Sahbaz, Burcin, Bonic, Karla, Origel Marmolejo, Carlos A., Quentel, Arnaud, Plaut, Justin S., Kawashima, Taryn E., Ozdemir, E. Sila, Malhotra, Sanjay V., Ahiska, Yavuz, Sezerman, Ugur, Bayram Akcapinar, Gunseli, Saldivar, Joshua C., Timucin, Emel, Fischer, Jared M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546421/
https://www.ncbi.nlm.nih.gov/pubmed/34689087
http://dx.doi.org/10.1016/j.ebiom.2021.103646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546421/
https://www.ncbi.nlm.nih.gov/pubmed/34689087
http://dx.doi.org/10.1016/j.ebiom.2021.103646

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