High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment

Tubo-ovarian high-grade serous carcinoma (HGSC) is unresponsive to immune checkpoint blockade despite significant frequencies of exhausted T cells. Here we apply mass cytometry and uncover decidual-like natural killer (dl-NK) cell subpopulations (CD56+CD9+CXCR3+KIR+CD3−CD16−) in newly diagnosed HGSC...

Descripción completa

Detalles Bibliográficos
Autores principales: Gonzalez, Veronica D., Huang, Ying-Wen, Delgado-Gonzalez, Antonio, Chen, Shih-Yu, Donoso, Kenyi, Sachs, Karen, Gentles, Andrew J., Allard, Grace M., Kolahi, Kevin S., Howitt, Brooke E., Porpiglia, Ermelinda, Fantl, Wendy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546503/
https://www.ncbi.nlm.nih.gov/pubmed/34469729
http://dx.doi.org/10.1016/j.celrep.2021.109632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546503/
https://www.ncbi.nlm.nih.gov/pubmed/34469729
http://dx.doi.org/10.1016/j.celrep.2021.109632

Ejemplares similares