Cargando…

High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment

Tubo-ovarian high-grade serous carcinoma (HGSC) is unresponsive to immune checkpoint blockade despite significant frequencies of exhausted T cells. Here we apply mass cytometry and uncover decidual-like natural killer (dl-NK) cell subpopulations (CD56+CD9+CXCR3+KIR+CD3−CD16−) in newly diagnosed HGSC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gonzalez, Veronica D., Huang, Ying-Wen, Delgado-Gonzalez, Antonio, Chen, Shih-Yu, Donoso, Kenyi, Sachs, Karen, Gentles, Andrew J., Allard, Grace M., Kolahi, Kevin S., Howitt, Brooke E., Porpiglia, Ermelinda, Fantl, Wendy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546503/ https://www.ncbi.nlm.nih.gov/pubmed/34469729 http://dx.doi.org/10.1016/j.celrep.2021.109632

Ejemplares similares

Measuring trogocytosis between ovarian tumor and natural killer cells
por: Delgado-Gonzalez, Antonio, et al.
Publicado: (2022)

Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors
por: Funingana, Ionut-Gabriel, et al.
Publicado: (2023)

NK Cell Metabolism and Tumor Microenvironment
por: Terrén, Iñigo, et al.
Publicado: (2019)

NK cell exhaustion in the tumor microenvironment
por: Jia, Hao, et al.
Publicado: (2023)

The Adverse Impact of Tumor Microenvironment on NK-Cell
por: Hu, Ziming, et al.
Publicado: (2021)

Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry
por: Gonzalez, Veronica D., et al.
Publicado: (2018)

Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer
por: Launonen, I.-M., et al.
Publicado: (2022)

Tumor microenvironment in NSCLC suppresses NK cells function
por: Cremer, Isabelle, et al.
Publicado: (2012)

Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function
por: Degos, Clara, et al.
Publicado: (2019)

Hepatic Tumor Microenvironments and Effects on NK Cell Phenotype and Function
por: Piñeiro Fernández, Julián, et al.
Publicado: (2019)

Influence of the Tumor Microenvironment on NK Cell Function in Solid Tumors
por: Melaiu, Ombretta, et al.
Publicado: (2020)

Arrested development: suppression of NK cell function in the tumor microenvironment
por: Riggan, Luke, et al.
Publicado: (2021)

The Tumor Microenvironment—A Metabolic Obstacle to NK Cells’ Activity
por: Domagala, Joanna, et al.
Publicado: (2020)

NK cells are never alone: crosstalk and communication in tumour microenvironments
por: Zhou, Yongqiang, et al.
Publicado: (2023)

Creating Structured Hydrogel Microenvironments for Regulating Stem Cell Differentiation
por: Mills, David K., et al.
Publicado: (2020)

Periosteal topology creates an osteo-friendly microenvironment for progenitor cells
por: Pan, Jun, et al.
Publicado: (2022)

NK Cells in the Treatment of Hematological Malignancies
por: Gonzalez-Rodriguez, Ana P, et al.
Publicado: (2019)

Hybrid Fluorescent Mass-Tag Nanotrackers as Universal Reagents for Long-Term Live-Cell Barcoding
por: Delgado-Gonzalez, Antonio, et al.
Publicado: (2022)

Tumor Microenvironment-Associated Extracellular Matrix Components Regulate NK Cell Function
por: Rossi, Gustavo Rodrigues, et al.
Publicado: (2020)

Design and Implementation of NK Cell-Based Immunotherapy to Overcome the Solid Tumor Microenvironment
por: Navin, Ishwar, et al.
Publicado: (2020)

Editorial: NK-Myeloid Cell Interactions in the Tumor Microenvironment: Implications for Cancer Immunotherapy
por: Wennerberg, Erik, et al.
Publicado: (2021)

Optimizing NK Cell-Based Immunotherapy in Myeloid Leukemia: Abrogating an Immunosuppressive Microenvironment
por: Kaweme, Natasha Mupeta, et al.
Publicado: (2021)

Targeting the Microenvironment in High Grade Serous Ovarian Cancer
por: Nwani, Nkechiyere G., et al.
Publicado: (2018)

The Tumor Microenvironment of High Grade Serous Ovarian Cancer
por: Stack, M. Sharon, et al.
Publicado: (2018)

Myofibroblasts Derived from Hepatic Progenitor Cells Create the Tumor Microenvironment
por: Sekiya, Sayaka, et al.
Publicado: (2016)

Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids
por: Thai, Victoria L., et al.
Publicado: (2023)

NK Cell-Based Immunotherapy in Cancer Metastasis
por: Lorenzo-Herrero, Seila, et al.
Publicado: (2018)

Mechanisms of Resistance to NK Cell Immunotherapy
por: Sordo-Bahamonde, Christian, et al.
Publicado: (2020)

Lung Tumor Microenvironment Induces Specific Gene Expression Signature in Intratumoral NK Cells
por: Gillard-Bocquet, Mélanie, et al.
Publicado: (2013)

Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic Stress
por: Hasmim, Meriem, et al.
Publicado: (2015)

CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis
por: Morgan, Huw J., et al.
Publicado: (2022)

Lactate from the tumor microenvironment - A key obstacle in NK cell-based immunotherapies
por: Jedlička, Marek, et al.
Publicado: (2022)

The tumor microenvironment drives NK cell metabolic dysfunction leading to impaired antitumor activity
por: Tumino, Nicola, et al.
Publicado: (2022)

Dysregulation of DNAM-1-Mediated NK Cell Anti-Cancer Responses in the Tumor Microenvironment
por: Paolini, Rossella, et al.
Publicado: (2023)

The peritoneal tumour microenvironment of high-grade serous ovarian cancer
por: Leinster, D Andrew, et al.
Publicado: (2012)

Innate lymphoid cells facilitate NK cell development through a lymphotoxin-mediated stromal microenvironment
por: Kim, Tae-Jin, et al.
Publicado: (2014)

NK cell-derived IL-10 is critical for DC-NK cell dialogue at the maternal-fetal interface
por: Blois, Sandra M., et al.
Publicado: (2017)

Cell lysates and egg white create homeostatic microenvironment for gene expression in cell-free system
por: Liu, Yang, et al.
Publicado: (2018)

Intrinsic Disorder in the T Cell Receptor Creates Cooperativity and Controls ZAP70 Binding
por: Clemens, Lara, et al.
Publicado: (2021)

Programmed cell death-1 receptor-mediated regulation of Tbet(+)NK1.1(−) innate lymphoid cells within the tumor microenvironment
por: Lim, Jing Xuan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_n17vsu03u29i91li12j6ciidnv