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Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 11: Sulfonamides

The specific concentrations of sulfonamides in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed whi...

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Autores principales: Koutsoumanis, Konstantinos, Allende, Ana, Alvarez‐Ordóñez, Avelino, Bolton, Declan, Bover‐Cid, Sara, Chemaly, Marianne, Davies, Robert, De Cesare, Alessandra, Herman, Lieve, Hilbert, Friederike, Lindqvist, Roland, Nauta, Maarten, Ru, Giuseppe, Simmons, Marion, Skandamis, Panagiotis, Suffredini, Elisabetta, Andersson, Dan I., Bampidis, Vasileios, Bengtsson‐Palme, Johan, Bouchard, Damien, Ferran, Aude, Kouba, Maryline, López Puente, Secundino, López‐Alonso, Marta, Nielsen, Søren Saxmose, Pechová, Alena, Petkova, Mariana, Girault, Sebastien, Broglia, Alessandro, Guerra, Beatriz, Innocenti, Matteo Lorenzo, Liébana, Ernesto, López‐Gálvez, Gloria, Manini, Paola, Stella, Pietro, Peixe, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546515/
https://www.ncbi.nlm.nih.gov/pubmed/34729091
http://dx.doi.org/10.2903/j.efsa.2021.6863
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author Koutsoumanis, Konstantinos
Allende, Ana
Alvarez‐Ordóñez, Avelino
Bolton, Declan
Bover‐Cid, Sara
Chemaly, Marianne
Davies, Robert
De Cesare, Alessandra
Herman, Lieve
Hilbert, Friederike
Lindqvist, Roland
Nauta, Maarten
Ru, Giuseppe
Simmons, Marion
Skandamis, Panagiotis
Suffredini, Elisabetta
Andersson, Dan I.
Bampidis, Vasileios
Bengtsson‐Palme, Johan
Bouchard, Damien
Ferran, Aude
Kouba, Maryline
López Puente, Secundino
López‐Alonso, Marta
Nielsen, Søren Saxmose
Pechová, Alena
Petkova, Mariana
Girault, Sebastien
Broglia, Alessandro
Guerra, Beatriz
Innocenti, Matteo Lorenzo
Liébana, Ernesto
López‐Gálvez, Gloria
Manini, Paola
Stella, Pietro
Peixe, Luisa
author_facet Koutsoumanis, Konstantinos
Allende, Ana
Alvarez‐Ordóñez, Avelino
Bolton, Declan
Bover‐Cid, Sara
Chemaly, Marianne
Davies, Robert
De Cesare, Alessandra
Herman, Lieve
Hilbert, Friederike
Lindqvist, Roland
Nauta, Maarten
Ru, Giuseppe
Simmons, Marion
Skandamis, Panagiotis
Suffredini, Elisabetta
Andersson, Dan I.
Bampidis, Vasileios
Bengtsson‐Palme, Johan
Bouchard, Damien
Ferran, Aude
Kouba, Maryline
López Puente, Secundino
López‐Alonso, Marta
Nielsen, Søren Saxmose
Pechová, Alena
Petkova, Mariana
Girault, Sebastien
Broglia, Alessandro
Guerra, Beatriz
Innocenti, Matteo Lorenzo
Liébana, Ernesto
López‐Gálvez, Gloria
Manini, Paola
Stella, Pietro
Peixe, Luisa
collection PubMed
description The specific concentrations of sulfonamides in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data are available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were identified for three sulfonamides: sulfamethazine, sulfathiazole and sulfamerazine. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these antimicrobials.
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spelling pubmed-85465152021-11-01 Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 11: Sulfonamides Koutsoumanis, Konstantinos Allende, Ana Alvarez‐Ordóñez, Avelino Bolton, Declan Bover‐Cid, Sara Chemaly, Marianne Davies, Robert De Cesare, Alessandra Herman, Lieve Hilbert, Friederike Lindqvist, Roland Nauta, Maarten Ru, Giuseppe Simmons, Marion Skandamis, Panagiotis Suffredini, Elisabetta Andersson, Dan I. Bampidis, Vasileios Bengtsson‐Palme, Johan Bouchard, Damien Ferran, Aude Kouba, Maryline López Puente, Secundino López‐Alonso, Marta Nielsen, Søren Saxmose Pechová, Alena Petkova, Mariana Girault, Sebastien Broglia, Alessandro Guerra, Beatriz Innocenti, Matteo Lorenzo Liébana, Ernesto López‐Gálvez, Gloria Manini, Paola Stella, Pietro Peixe, Luisa EFSA J Scientific Opinion The specific concentrations of sulfonamides in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data are available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were identified for three sulfonamides: sulfamethazine, sulfathiazole and sulfamerazine. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these antimicrobials. John Wiley and Sons Inc. 2021-10-26 /pmc/articles/PMC8546515/ /pubmed/34729091 http://dx.doi.org/10.2903/j.efsa.2021.6863 Text en © 2021 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Koutsoumanis, Konstantinos
Allende, Ana
Alvarez‐Ordóñez, Avelino
Bolton, Declan
Bover‐Cid, Sara
Chemaly, Marianne
Davies, Robert
De Cesare, Alessandra
Herman, Lieve
Hilbert, Friederike
Lindqvist, Roland
Nauta, Maarten
Ru, Giuseppe
Simmons, Marion
Skandamis, Panagiotis
Suffredini, Elisabetta
Andersson, Dan I.
Bampidis, Vasileios
Bengtsson‐Palme, Johan
Bouchard, Damien
Ferran, Aude
Kouba, Maryline
López Puente, Secundino
López‐Alonso, Marta
Nielsen, Søren Saxmose
Pechová, Alena
Petkova, Mariana
Girault, Sebastien
Broglia, Alessandro
Guerra, Beatriz
Innocenti, Matteo Lorenzo
Liébana, Ernesto
López‐Gálvez, Gloria
Manini, Paola
Stella, Pietro
Peixe, Luisa
Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 11: Sulfonamides
title Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 11: Sulfonamides
title_full Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 11: Sulfonamides
title_fullStr Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 11: Sulfonamides
title_full_unstemmed Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 11: Sulfonamides
title_short Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 11: Sulfonamides
title_sort maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. part 11: sulfonamides
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546515/
https://www.ncbi.nlm.nih.gov/pubmed/34729091
http://dx.doi.org/10.2903/j.efsa.2021.6863
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