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Neutralisation of SARS‐CoV‐2 by anatomical embalming solutions

Teaching and learning anatomy by using human cadaveric specimens has been a foundation of medical and biomedical teaching for hundreds of years. Therefore, the majority of institutions that teach topographical anatomy rely on body donation programmes to provide specimens for both undergraduate and p...

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Autores principales: Quondamatteo, Fabio, Corzo‐Leon, Dora E., Brassett, Cecilia, Colquhoun, Ian, Davies, David C., Dockery, Peter, Grenham, Sue, Guild, Simon, Hunter, Amanda, Jones, James, Lee, Thomas C., Tracey, Chris, Wilkinson, Tracey, Munro, Carol A., Gillingwater, Thomas H., Parson, Simon H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546517/
https://www.ncbi.nlm.nih.gov/pubmed/34633083
http://dx.doi.org/10.1111/joa.13549
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author Quondamatteo, Fabio
Corzo‐Leon, Dora E.
Brassett, Cecilia
Colquhoun, Ian
Davies, David C.
Dockery, Peter
Grenham, Sue
Guild, Simon
Hunter, Amanda
Jones, James
Lee, Thomas C.
Tracey, Chris
Wilkinson, Tracey
Munro, Carol A.
Gillingwater, Thomas H.
Parson, Simon H.
author_facet Quondamatteo, Fabio
Corzo‐Leon, Dora E.
Brassett, Cecilia
Colquhoun, Ian
Davies, David C.
Dockery, Peter
Grenham, Sue
Guild, Simon
Hunter, Amanda
Jones, James
Lee, Thomas C.
Tracey, Chris
Wilkinson, Tracey
Munro, Carol A.
Gillingwater, Thomas H.
Parson, Simon H.
author_sort Quondamatteo, Fabio
collection PubMed
description Teaching and learning anatomy by using human cadaveric specimens has been a foundation of medical and biomedical teaching for hundreds of years. Therefore, the majority of institutions that teach topographical anatomy rely on body donation programmes to provide specimens for both undergraduate and postgraduate teaching of gross anatomy. The COVID‐19 pandemic has posed an unprecedented challenge to anatomy teaching because of the suspension of donor acceptance at most institutions. This was largely due to concerns about the potential transmissibility of the SARS‐CoV‐2 virus and the absence of data about the ability of embalming solutions to neutralise the virus. Twenty embalming solutions commonly used in institutions in the United Kingdom and Ireland were tested for their ability to neutralise SARS‐CoV‐2, using an established cytotoxicity assay. All embalming solutions tested neutralised SARS‐CoV‐2, with the majority of solutions being effective at high‐working dilutions. These results suggest that successful embalming with the tested solutions can neutralise the SARS‐CoV‐2 virus, thereby facilitating the safe resumption of body donation programmes and cadaveric anatomy teaching.
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spelling pubmed-85465172021-11-01 Neutralisation of SARS‐CoV‐2 by anatomical embalming solutions Quondamatteo, Fabio Corzo‐Leon, Dora E. Brassett, Cecilia Colquhoun, Ian Davies, David C. Dockery, Peter Grenham, Sue Guild, Simon Hunter, Amanda Jones, James Lee, Thomas C. Tracey, Chris Wilkinson, Tracey Munro, Carol A. Gillingwater, Thomas H. Parson, Simon H. J Anat Brief Communication Teaching and learning anatomy by using human cadaveric specimens has been a foundation of medical and biomedical teaching for hundreds of years. Therefore, the majority of institutions that teach topographical anatomy rely on body donation programmes to provide specimens for both undergraduate and postgraduate teaching of gross anatomy. The COVID‐19 pandemic has posed an unprecedented challenge to anatomy teaching because of the suspension of donor acceptance at most institutions. This was largely due to concerns about the potential transmissibility of the SARS‐CoV‐2 virus and the absence of data about the ability of embalming solutions to neutralise the virus. Twenty embalming solutions commonly used in institutions in the United Kingdom and Ireland were tested for their ability to neutralise SARS‐CoV‐2, using an established cytotoxicity assay. All embalming solutions tested neutralised SARS‐CoV‐2, with the majority of solutions being effective at high‐working dilutions. These results suggest that successful embalming with the tested solutions can neutralise the SARS‐CoV‐2 virus, thereby facilitating the safe resumption of body donation programmes and cadaveric anatomy teaching. John Wiley and Sons Inc. 2021-10-11 2021-11 /pmc/articles/PMC8546517/ /pubmed/34633083 http://dx.doi.org/10.1111/joa.13549 Text en © 2021 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Quondamatteo, Fabio
Corzo‐Leon, Dora E.
Brassett, Cecilia
Colquhoun, Ian
Davies, David C.
Dockery, Peter
Grenham, Sue
Guild, Simon
Hunter, Amanda
Jones, James
Lee, Thomas C.
Tracey, Chris
Wilkinson, Tracey
Munro, Carol A.
Gillingwater, Thomas H.
Parson, Simon H.
Neutralisation of SARS‐CoV‐2 by anatomical embalming solutions
title Neutralisation of SARS‐CoV‐2 by anatomical embalming solutions
title_full Neutralisation of SARS‐CoV‐2 by anatomical embalming solutions
title_fullStr Neutralisation of SARS‐CoV‐2 by anatomical embalming solutions
title_full_unstemmed Neutralisation of SARS‐CoV‐2 by anatomical embalming solutions
title_short Neutralisation of SARS‐CoV‐2 by anatomical embalming solutions
title_sort neutralisation of sars‐cov‐2 by anatomical embalming solutions
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546517/
https://www.ncbi.nlm.nih.gov/pubmed/34633083
http://dx.doi.org/10.1111/joa.13549
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