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Host Stress Signals Stimulate Pneumococcal Transition from Colonization to Dissemination into the Lungs
Streptococcus pneumoniae is an asymptomatic colonizer of the nasopharynx, but it is also one of the most important bacterial pathogens of humans, causing a wide range of mild to life-threatening diseases. The basis of the pneumococcal transition from a commensal to a parasitic lifestyle is not fully...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546540/ https://www.ncbi.nlm.nih.gov/pubmed/34696596 http://dx.doi.org/10.1128/mBio.02569-21 |
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author | Alghofaili, Fayez Najmuldeen, Hastyar Kareem, Banaz O. Shlla, Bushra Fernandes, Vitor E. Danielsen, Morten Ketley, Julian M. Freestone, Primrose Yesilkaya, Hasan |
author_facet | Alghofaili, Fayez Najmuldeen, Hastyar Kareem, Banaz O. Shlla, Bushra Fernandes, Vitor E. Danielsen, Morten Ketley, Julian M. Freestone, Primrose Yesilkaya, Hasan |
author_sort | Alghofaili, Fayez |
collection | PubMed |
description | Streptococcus pneumoniae is an asymptomatic colonizer of the nasopharynx, but it is also one of the most important bacterial pathogens of humans, causing a wide range of mild to life-threatening diseases. The basis of the pneumococcal transition from a commensal to a parasitic lifestyle is not fully understood. We hypothesize that exposure to host catecholamine stress hormones is important for this transition. In this study, we demonstrated that pneumococci preexposed to a hormone released during stress, norepinephrine (NE), have an increased capacity to translocate from the nasopharynx into the lungs compared to untreated pneumococci. Examination of NE-treated pneumococci revealed major alterations in metabolic profiles, cell associations, capsule synthesis, and cell size. By systemically mutating all 12 two-component and 1 orphan regulatory systems, we also identified a unique genetic regulatory circuit involved in pneumococcal recognition and responsiveness to human stress hormones. |
format | Online Article Text |
id | pubmed-8546540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-85465402021-10-27 Host Stress Signals Stimulate Pneumococcal Transition from Colonization to Dissemination into the Lungs Alghofaili, Fayez Najmuldeen, Hastyar Kareem, Banaz O. Shlla, Bushra Fernandes, Vitor E. Danielsen, Morten Ketley, Julian M. Freestone, Primrose Yesilkaya, Hasan mBio Research Article Streptococcus pneumoniae is an asymptomatic colonizer of the nasopharynx, but it is also one of the most important bacterial pathogens of humans, causing a wide range of mild to life-threatening diseases. The basis of the pneumococcal transition from a commensal to a parasitic lifestyle is not fully understood. We hypothesize that exposure to host catecholamine stress hormones is important for this transition. In this study, we demonstrated that pneumococci preexposed to a hormone released during stress, norepinephrine (NE), have an increased capacity to translocate from the nasopharynx into the lungs compared to untreated pneumococci. Examination of NE-treated pneumococci revealed major alterations in metabolic profiles, cell associations, capsule synthesis, and cell size. By systemically mutating all 12 two-component and 1 orphan regulatory systems, we also identified a unique genetic regulatory circuit involved in pneumococcal recognition and responsiveness to human stress hormones. American Society for Microbiology 2021-10-26 /pmc/articles/PMC8546540/ /pubmed/34696596 http://dx.doi.org/10.1128/mBio.02569-21 Text en Copyright © 2021 Alghofaili et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Alghofaili, Fayez Najmuldeen, Hastyar Kareem, Banaz O. Shlla, Bushra Fernandes, Vitor E. Danielsen, Morten Ketley, Julian M. Freestone, Primrose Yesilkaya, Hasan Host Stress Signals Stimulate Pneumococcal Transition from Colonization to Dissemination into the Lungs |
title | Host Stress Signals Stimulate Pneumococcal Transition from Colonization to Dissemination into the Lungs |
title_full | Host Stress Signals Stimulate Pneumococcal Transition from Colonization to Dissemination into the Lungs |
title_fullStr | Host Stress Signals Stimulate Pneumococcal Transition from Colonization to Dissemination into the Lungs |
title_full_unstemmed | Host Stress Signals Stimulate Pneumococcal Transition from Colonization to Dissemination into the Lungs |
title_short | Host Stress Signals Stimulate Pneumococcal Transition from Colonization to Dissemination into the Lungs |
title_sort | host stress signals stimulate pneumococcal transition from colonization to dissemination into the lungs |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546540/ https://www.ncbi.nlm.nih.gov/pubmed/34696596 http://dx.doi.org/10.1128/mBio.02569-21 |
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