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Antimicrobial Peptides—or How Our Ancestors Learned to Control the Microbiome
Antimicrobial peptides (AMPs) are short and generally positively charged peptides found in a wide variety of life forms from microorganisms to humans. Their wide range of activity against pathogens, including Gram-positive and -negative bacteria, yeasts, fungi, and enveloped viruses makes them a fun...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546549/ https://www.ncbi.nlm.nih.gov/pubmed/34579574 http://dx.doi.org/10.1128/mBio.01847-21 |
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author | Bosch, Thomas C. G. Zasloff, Michael |
author_facet | Bosch, Thomas C. G. Zasloff, Michael |
author_sort | Bosch, Thomas C. G. |
collection | PubMed |
description | Antimicrobial peptides (AMPs) are short and generally positively charged peptides found in a wide variety of life forms from microorganisms to humans. Their wide range of activity against pathogens, including Gram-positive and -negative bacteria, yeasts, fungi, and enveloped viruses makes them a fundamental component of innate immunity. Marra et al. (A. Marra, M. A. Hanson, S. Kondo, B. Erkosar, B. Lemaitre, mBio 12:e0082421, 2021, https://doi.org/10.1128/mBio.00824-21) use the analytical potential of Drosophila to show that AMPs and lysozymes play a direct role in controlling the composition and abundance of the beneficial gut microbiome. By comparing mutant and wild-type flies, they demonstrated that the specific loss of AMPs and lysozyme production results in changes in microbiome abundance and composition. Furthermore, they established that AMPs and lysozyme are particularly essential in aging flies. Studies of early emerging metazoans, other invertebrates, and humans support the view of an ancestral function of AMPs in controlling microbial colonization. |
format | Online Article Text |
id | pubmed-8546549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-85465492021-11-04 Antimicrobial Peptides—or How Our Ancestors Learned to Control the Microbiome Bosch, Thomas C. G. Zasloff, Michael mBio Commentary Antimicrobial peptides (AMPs) are short and generally positively charged peptides found in a wide variety of life forms from microorganisms to humans. Their wide range of activity against pathogens, including Gram-positive and -negative bacteria, yeasts, fungi, and enveloped viruses makes them a fundamental component of innate immunity. Marra et al. (A. Marra, M. A. Hanson, S. Kondo, B. Erkosar, B. Lemaitre, mBio 12:e0082421, 2021, https://doi.org/10.1128/mBio.00824-21) use the analytical potential of Drosophila to show that AMPs and lysozymes play a direct role in controlling the composition and abundance of the beneficial gut microbiome. By comparing mutant and wild-type flies, they demonstrated that the specific loss of AMPs and lysozyme production results in changes in microbiome abundance and composition. Furthermore, they established that AMPs and lysozyme are particularly essential in aging flies. Studies of early emerging metazoans, other invertebrates, and humans support the view of an ancestral function of AMPs in controlling microbial colonization. American Society for Microbiology 2021-09-28 /pmc/articles/PMC8546549/ /pubmed/34579574 http://dx.doi.org/10.1128/mBio.01847-21 Text en Copyright © 2021 Bosch and Zasloff. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Commentary Bosch, Thomas C. G. Zasloff, Michael Antimicrobial Peptides—or How Our Ancestors Learned to Control the Microbiome |
title | Antimicrobial Peptides—or How Our Ancestors Learned to Control the Microbiome |
title_full | Antimicrobial Peptides—or How Our Ancestors Learned to Control the Microbiome |
title_fullStr | Antimicrobial Peptides—or How Our Ancestors Learned to Control the Microbiome |
title_full_unstemmed | Antimicrobial Peptides—or How Our Ancestors Learned to Control the Microbiome |
title_short | Antimicrobial Peptides—or How Our Ancestors Learned to Control the Microbiome |
title_sort | antimicrobial peptides—or how our ancestors learned to control the microbiome |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546549/ https://www.ncbi.nlm.nih.gov/pubmed/34579574 http://dx.doi.org/10.1128/mBio.01847-21 |
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