Polyketide Starter and Extender Units Serve as Regulatory Ligands to Coordinate the Biosynthesis of Antibiotics in Actinomycetes

Polyketides are one of the largest categories of secondary metabolites, and their biosynthesis is initiated by polyketide synthases (PKSs) using coenzyme A esters of short fatty acids (acyl-CoAs) as starter and extender units. In this study, we discover a universal regulatory mechanism in which the...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Panpan, Chen, Ketao, Li, Bowen, Zhang, Yanni, Wu, Hang, Chen, Yuhong, Ren, Shaohua, Khan, Sabir, Zhang, Lixin, Zhang, Buchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546615/
https://www.ncbi.nlm.nih.gov/pubmed/34579580
http://dx.doi.org/10.1128/mBio.02298-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546615/
https://www.ncbi.nlm.nih.gov/pubmed/34579580
http://dx.doi.org/10.1128/mBio.02298-21

Ejemplares similares