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Relationship between Th17 immune response and cancer
Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades. Cancer has a close relationship with the immune system and, although Th17 cells are known to play roles in the immune response against microorganisms and...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546660/ https://www.ncbi.nlm.nih.gov/pubmed/34733609 http://dx.doi.org/10.5306/wjco.v12.i10.845 |
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author | Marques, Hanna Santos de Brito, Breno Bittencourt da Silva, Filipe Antônio França Santos, Maria Luísa Cordeiro de Souza, Júlio César Braga Correia, Thiago Macêdo Lopes Lopes, Luana Weber Neres, Nayara Silva de Macêdo Dórea, Rafael Santos Dantas Miranda Dantas, Anna Carolina Saúde Morbeck, Lorena Lôbo Brito Lima, Iasmin Souza de Almeida, Amanda Alves Dias, Maiara Raulina de Jesus de Melo, Fabrício Freire |
author_facet | Marques, Hanna Santos de Brito, Breno Bittencourt da Silva, Filipe Antônio França Santos, Maria Luísa Cordeiro de Souza, Júlio César Braga Correia, Thiago Macêdo Lopes Lopes, Luana Weber Neres, Nayara Silva de Macêdo Dórea, Rafael Santos Dantas Miranda Dantas, Anna Carolina Saúde Morbeck, Lorena Lôbo Brito Lima, Iasmin Souza de Almeida, Amanda Alves Dias, Maiara Raulina de Jesus de Melo, Fabrício Freire |
author_sort | Marques, Hanna Santos |
collection | PubMed |
description | Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades. Cancer has a close relationship with the immune system and, although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity, studies have emphasized their roles in cancer pathogenesis. The Th17 immune response profile is involved in several types of cancer including urogenital, respiratory, gastrointestinal, and skin cancers. This type of immune response exerts pro and antitumor functions through several mechanisms, depending on the context of each tumor, including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment. Among other factors, the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential, which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells. Interleukin (IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment, which allow Th17 cells to prevail in tumors. Moreover, the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers, being associated with variable clinical outcomes. The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. |
format | Online Article Text |
id | pubmed-8546660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-85466602021-11-02 Relationship between Th17 immune response and cancer Marques, Hanna Santos de Brito, Breno Bittencourt da Silva, Filipe Antônio França Santos, Maria Luísa Cordeiro de Souza, Júlio César Braga Correia, Thiago Macêdo Lopes Lopes, Luana Weber Neres, Nayara Silva de Macêdo Dórea, Rafael Santos Dantas Miranda Dantas, Anna Carolina Saúde Morbeck, Lorena Lôbo Brito Lima, Iasmin Souza de Almeida, Amanda Alves Dias, Maiara Raulina de Jesus de Melo, Fabrício Freire World J Clin Oncol Review Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades. Cancer has a close relationship with the immune system and, although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity, studies have emphasized their roles in cancer pathogenesis. The Th17 immune response profile is involved in several types of cancer including urogenital, respiratory, gastrointestinal, and skin cancers. This type of immune response exerts pro and antitumor functions through several mechanisms, depending on the context of each tumor, including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment. Among other factors, the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential, which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells. Interleukin (IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment, which allow Th17 cells to prevail in tumors. Moreover, the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers, being associated with variable clinical outcomes. The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. Baishideng Publishing Group Inc 2021-10-24 2021-10-24 /pmc/articles/PMC8546660/ /pubmed/34733609 http://dx.doi.org/10.5306/wjco.v12.i10.845 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Review Marques, Hanna Santos de Brito, Breno Bittencourt da Silva, Filipe Antônio França Santos, Maria Luísa Cordeiro de Souza, Júlio César Braga Correia, Thiago Macêdo Lopes Lopes, Luana Weber Neres, Nayara Silva de Macêdo Dórea, Rafael Santos Dantas Miranda Dantas, Anna Carolina Saúde Morbeck, Lorena Lôbo Brito Lima, Iasmin Souza de Almeida, Amanda Alves Dias, Maiara Raulina de Jesus de Melo, Fabrício Freire Relationship between Th17 immune response and cancer |
title | Relationship between Th17 immune response and cancer |
title_full | Relationship between Th17 immune response and cancer |
title_fullStr | Relationship between Th17 immune response and cancer |
title_full_unstemmed | Relationship between Th17 immune response and cancer |
title_short | Relationship between Th17 immune response and cancer |
title_sort | relationship between th17 immune response and cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546660/ https://www.ncbi.nlm.nih.gov/pubmed/34733609 http://dx.doi.org/10.5306/wjco.v12.i10.845 |
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