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Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development
Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance, preventing autoimmune responses, and minimizing tissue damage by regulating the duration and intensity of the immune response. Furthermore, immune checkpoints are usually overexpres...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546663/ https://www.ncbi.nlm.nih.gov/pubmed/34729298 http://dx.doi.org/10.1016/j.apsb.2021.03.004 |
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author | Wang, Yuli Zhang, Xingyan Wang, Yuyan Zhao, Wenjing Li, Huling Zhang, Lixing Li, Xinping Zhang, Tiejun Zhang, Hongbing Huang, He Liu, Changxiao |
author_facet | Wang, Yuli Zhang, Xingyan Wang, Yuyan Zhao, Wenjing Li, Huling Zhang, Lixing Li, Xinping Zhang, Tiejun Zhang, Hongbing Huang, He Liu, Changxiao |
author_sort | Wang, Yuli |
collection | PubMed |
description | Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance, preventing autoimmune responses, and minimizing tissue damage by regulating the duration and intensity of the immune response. Furthermore, immune checkpoints are usually overexpressed in cancer cells or noninvasive cells in tumor tissues and are capable of suppressing the antitumor response. Based on substantial physiological analyses as well as preclinical and clinical studies, checkpoint molecules have been evaluated as potential therapeutic targets for the treatment of multiple types of cancers. In the last few years, extensive evidence has supported the immunoregulatory effects of traditional Chinese medicines (TCMs). The main advantage of TCMs and natural medicine is that they usually contain multiple active components, which can act on multiple targets at the same time, resulting in additive or synergistic effects. The strong immune regulation function of traditional Chinese medicine on immune checkpoints has also been of great interest. For example, Astragalus membranaceus polysaccharides can induce anti-PD-1 antibody responses in animals, and these antibodies can overcome the exhaustion of immune cells under tumor immune evasion. Furthermore, many other TCM molecules could also be novel and effective drug candidates for the treatment of cancers. Therefore, it is essential to assess the application of immune checkpoints in the development of new drugs and TCMs. In this review, we focus on research progress in the field of immune checkpoints based on three topics: (1) immune checkpoint targets and pathways, (2) development of novel immune checkpoint-based drugs, and (3) application of immune checkpoints in the development of TCMs. |
format | Online Article Text |
id | pubmed-8546663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-85466632021-11-01 Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development Wang, Yuli Zhang, Xingyan Wang, Yuyan Zhao, Wenjing Li, Huling Zhang, Lixing Li, Xinping Zhang, Tiejun Zhang, Hongbing Huang, He Liu, Changxiao Acta Pharm Sin B Review Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance, preventing autoimmune responses, and minimizing tissue damage by regulating the duration and intensity of the immune response. Furthermore, immune checkpoints are usually overexpressed in cancer cells or noninvasive cells in tumor tissues and are capable of suppressing the antitumor response. Based on substantial physiological analyses as well as preclinical and clinical studies, checkpoint molecules have been evaluated as potential therapeutic targets for the treatment of multiple types of cancers. In the last few years, extensive evidence has supported the immunoregulatory effects of traditional Chinese medicines (TCMs). The main advantage of TCMs and natural medicine is that they usually contain multiple active components, which can act on multiple targets at the same time, resulting in additive or synergistic effects. The strong immune regulation function of traditional Chinese medicine on immune checkpoints has also been of great interest. For example, Astragalus membranaceus polysaccharides can induce anti-PD-1 antibody responses in animals, and these antibodies can overcome the exhaustion of immune cells under tumor immune evasion. Furthermore, many other TCM molecules could also be novel and effective drug candidates for the treatment of cancers. Therefore, it is essential to assess the application of immune checkpoints in the development of new drugs and TCMs. In this review, we focus on research progress in the field of immune checkpoints based on three topics: (1) immune checkpoint targets and pathways, (2) development of novel immune checkpoint-based drugs, and (3) application of immune checkpoints in the development of TCMs. Elsevier 2021-10 2021-03-09 /pmc/articles/PMC8546663/ /pubmed/34729298 http://dx.doi.org/10.1016/j.apsb.2021.03.004 Text en © 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Wang, Yuli Zhang, Xingyan Wang, Yuyan Zhao, Wenjing Li, Huling Zhang, Lixing Li, Xinping Zhang, Tiejun Zhang, Hongbing Huang, He Liu, Changxiao Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development |
title | Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development |
title_full | Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development |
title_fullStr | Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development |
title_full_unstemmed | Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development |
title_short | Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development |
title_sort | application of immune checkpoint targets in the anti-tumor novel drugs and traditional chinese medicine development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546663/ https://www.ncbi.nlm.nih.gov/pubmed/34729298 http://dx.doi.org/10.1016/j.apsb.2021.03.004 |
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