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Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression
The mind is embodied; thoughts and feelings interact with states of physiological arousal and physical integrity of the body. In this context, there is mounting evidence for an association between psychiatric presentations and the expression variant connective tissue, commonly recognised as joint hy...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546774/ https://www.ncbi.nlm.nih.gov/pubmed/34733643 http://dx.doi.org/10.5498/wjp.v11.i10.805 |
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author | Sharp, Harriet Emma Clare Critchley, Hugo D Eccles, Jessica A |
author_facet | Sharp, Harriet Emma Clare Critchley, Hugo D Eccles, Jessica A |
author_sort | Sharp, Harriet Emma Clare |
collection | PubMed |
description | The mind is embodied; thoughts and feelings interact with states of physiological arousal and physical integrity of the body. In this context, there is mounting evidence for an association between psychiatric presentations and the expression variant connective tissue, commonly recognised as joint hypermobility. Joint hypermobility is common, frequently under-recognised, significantly impacts quality of life, and can exist in isolation or as the hallmark of hypermobility spectrum disorders (encompassing joint hypermobility syndrome and hypermobile Ehlers-Danlos syndrome). In this narrative review, we appraise the current evidence linking psychiatric disorders across the lifespan, beginning with the relatively well-established connection with anxiety, to hypermobility. We next consider emerging associations with affective illnesses, eating disorders, alongside less well researched links with personality disorders, substance misuse and psychosis. We then review related findings relevant to neurodevelopmental disorders and stress-sensitive medical conditions. With growing understanding of mind-body interactions, we discuss potential aetiopathogenetic contributions of dysautonomia, aberrant interoceptive processing, immune dysregulation and proprioceptive impairments in the context of psychosocial stressors and genetic predisposition. We examine clinical implications of these evolving findings, calling for increased awareness amongst healthcare professionals of the transdiagnostic nature of hypermobility and related disorders. A role for early screening and detection of hypermobility in those presenting with mental health and somatic symptoms is further highlighted, with a view to facilitate preventative approaches alongside longer-term holistic management strategies. Finally, suggestions are offered for directions of future scientific exploration which may be key to further delineating fundamental mind-body-brain interactions. |
format | Online Article Text |
id | pubmed-8546774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-85467742021-11-02 Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression Sharp, Harriet Emma Clare Critchley, Hugo D Eccles, Jessica A World J Psychiatry Minireviews The mind is embodied; thoughts and feelings interact with states of physiological arousal and physical integrity of the body. In this context, there is mounting evidence for an association between psychiatric presentations and the expression variant connective tissue, commonly recognised as joint hypermobility. Joint hypermobility is common, frequently under-recognised, significantly impacts quality of life, and can exist in isolation or as the hallmark of hypermobility spectrum disorders (encompassing joint hypermobility syndrome and hypermobile Ehlers-Danlos syndrome). In this narrative review, we appraise the current evidence linking psychiatric disorders across the lifespan, beginning with the relatively well-established connection with anxiety, to hypermobility. We next consider emerging associations with affective illnesses, eating disorders, alongside less well researched links with personality disorders, substance misuse and psychosis. We then review related findings relevant to neurodevelopmental disorders and stress-sensitive medical conditions. With growing understanding of mind-body interactions, we discuss potential aetiopathogenetic contributions of dysautonomia, aberrant interoceptive processing, immune dysregulation and proprioceptive impairments in the context of psychosocial stressors and genetic predisposition. We examine clinical implications of these evolving findings, calling for increased awareness amongst healthcare professionals of the transdiagnostic nature of hypermobility and related disorders. A role for early screening and detection of hypermobility in those presenting with mental health and somatic symptoms is further highlighted, with a view to facilitate preventative approaches alongside longer-term holistic management strategies. Finally, suggestions are offered for directions of future scientific exploration which may be key to further delineating fundamental mind-body-brain interactions. Baishideng Publishing Group Inc 2021-10-19 /pmc/articles/PMC8546774/ /pubmed/34733643 http://dx.doi.org/10.5498/wjp.v11.i10.805 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Minireviews Sharp, Harriet Emma Clare Critchley, Hugo D Eccles, Jessica A Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression |
title | Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression |
title_full | Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression |
title_fullStr | Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression |
title_full_unstemmed | Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression |
title_short | Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression |
title_sort | connecting brain and body: transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546774/ https://www.ncbi.nlm.nih.gov/pubmed/34733643 http://dx.doi.org/10.5498/wjp.v11.i10.805 |
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