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Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 9: Polymyxins: colistin
The specific concentrations of colistin in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which h...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546797/ https://www.ncbi.nlm.nih.gov/pubmed/34729089 http://dx.doi.org/10.2903/j.efsa.2021.6861 |
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author | Koutsoumanis, Konstantinos Allende, Ana Alvarez‐Ordóñez, Avelino Bolton, Declan Bover‐Cid, Sara Chemaly, Marianne Davies, Robert De Cesare, Alessandra Herman, Lieve Hilbert, Friederike Lindqvist, Roland Nauta, Maarten Ru, Giuseppe Simmons, Marion Skandamis, Panagiotis Suffredini, Elisabetta Andersson, Dan I. Bampidis, Vasileios Bengtsson‐Palme, Johan Bouchard, Damien Ferran, Aude Kouba, Maryline López Puente, Secundino López‐Alonso, Marta Nielsen, Søren Saxmose Pechová, Alena Petkova, Mariana Girault, Sebastien Broglia, Alessandro Guerra, Beatriz Innocenti, Matteo Lorenzo Liébana, Ernesto López‐Gálvez, Gloria Manini, Paola Stella, Pietro Peixe, Luisa |
author_facet | Koutsoumanis, Konstantinos Allende, Ana Alvarez‐Ordóñez, Avelino Bolton, Declan Bover‐Cid, Sara Chemaly, Marianne Davies, Robert De Cesare, Alessandra Herman, Lieve Hilbert, Friederike Lindqvist, Roland Nauta, Maarten Ru, Giuseppe Simmons, Marion Skandamis, Panagiotis Suffredini, Elisabetta Andersson, Dan I. Bampidis, Vasileios Bengtsson‐Palme, Johan Bouchard, Damien Ferran, Aude Kouba, Maryline López Puente, Secundino López‐Alonso, Marta Nielsen, Søren Saxmose Pechová, Alena Petkova, Mariana Girault, Sebastien Broglia, Alessandro Guerra, Beatriz Innocenti, Matteo Lorenzo Liébana, Ernesto López‐Gálvez, Gloria Manini, Paola Stella, Pietro Peixe, Luisa |
collection | PubMed |
description | The specific concentrations of colistin in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels of colistin in feed that showed to have an effect on growth promotion/increased yield were reported. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these antimicrobials. |
format | Online Article Text |
id | pubmed-8546797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85467972021-11-01 Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
Part 9: Polymyxins: colistin Koutsoumanis, Konstantinos Allende, Ana Alvarez‐Ordóñez, Avelino Bolton, Declan Bover‐Cid, Sara Chemaly, Marianne Davies, Robert De Cesare, Alessandra Herman, Lieve Hilbert, Friederike Lindqvist, Roland Nauta, Maarten Ru, Giuseppe Simmons, Marion Skandamis, Panagiotis Suffredini, Elisabetta Andersson, Dan I. Bampidis, Vasileios Bengtsson‐Palme, Johan Bouchard, Damien Ferran, Aude Kouba, Maryline López Puente, Secundino López‐Alonso, Marta Nielsen, Søren Saxmose Pechová, Alena Petkova, Mariana Girault, Sebastien Broglia, Alessandro Guerra, Beatriz Innocenti, Matteo Lorenzo Liébana, Ernesto López‐Gálvez, Gloria Manini, Paola Stella, Pietro Peixe, Luisa EFSA J Scientific Opinion The specific concentrations of colistin in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels of colistin in feed that showed to have an effect on growth promotion/increased yield were reported. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these antimicrobials. John Wiley and Sons Inc. 2021-10-26 /pmc/articles/PMC8546797/ /pubmed/34729089 http://dx.doi.org/10.2903/j.efsa.2021.6861 Text en © 2021 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Koutsoumanis, Konstantinos Allende, Ana Alvarez‐Ordóñez, Avelino Bolton, Declan Bover‐Cid, Sara Chemaly, Marianne Davies, Robert De Cesare, Alessandra Herman, Lieve Hilbert, Friederike Lindqvist, Roland Nauta, Maarten Ru, Giuseppe Simmons, Marion Skandamis, Panagiotis Suffredini, Elisabetta Andersson, Dan I. Bampidis, Vasileios Bengtsson‐Palme, Johan Bouchard, Damien Ferran, Aude Kouba, Maryline López Puente, Secundino López‐Alonso, Marta Nielsen, Søren Saxmose Pechová, Alena Petkova, Mariana Girault, Sebastien Broglia, Alessandro Guerra, Beatriz Innocenti, Matteo Lorenzo Liébana, Ernesto López‐Gálvez, Gloria Manini, Paola Stella, Pietro Peixe, Luisa Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 9: Polymyxins: colistin |
title | Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
Part 9: Polymyxins: colistin
|
title_full | Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
Part 9: Polymyxins: colistin
|
title_fullStr | Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
Part 9: Polymyxins: colistin
|
title_full_unstemmed | Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
Part 9: Polymyxins: colistin
|
title_short | Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
Part 9: Polymyxins: colistin
|
title_sort | maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed.
part 9: polymyxins: colistin |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546797/ https://www.ncbi.nlm.nih.gov/pubmed/34729089 http://dx.doi.org/10.2903/j.efsa.2021.6861 |
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