Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy

Receptor-interacting protein (RIP) kinase 1 is involved in immune-mediated inflammatory diseases including ulcerative colitis (UC) by regulating necroptosis and inflammation. Our group previously identified TAK-632 (5) as an effective necroptosis inhibitor by dual-targeting RIP1 and RIP3. In this st...

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Detalles Bibliográficos
Autores principales: Zhu, Jing, Xin, Meng, Xu, Congcong, He, Yuan, Zhang, Wannian, Wang, Zhibin, Zhuang, Chunlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546889/
https://www.ncbi.nlm.nih.gov/pubmed/34729309
http://dx.doi.org/10.1016/j.apsb.2021.05.017

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