Role of PRKDC in cancer initiation, progression, and treatment

The PRKDC gene encodes the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein. DNA-PKcs plays an important role in nonhomologous end joining (NHEJ) of DNA double-strand breaks (DSBs) and is also closely related to the establishment of central immune tolerance and the maintenance of ch...

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Autores principales: Chen, Yu, Li, Yi, Xiong, Jiani, Lan, Bin, Wang, Xuefeng, Liu, Jun, Lin, Jing, Fei, Zhaodong, Zheng, Xiaobin, Chen, Chuanben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547028/
https://www.ncbi.nlm.nih.gov/pubmed/34702253
http://dx.doi.org/10.1186/s12935-021-02229-8
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author Chen, Yu
Li, Yi
Xiong, Jiani
Lan, Bin
Wang, Xuefeng
Liu, Jun
Lin, Jing
Fei, Zhaodong
Zheng, Xiaobin
Chen, Chuanben
author_facet Chen, Yu
Li, Yi
Xiong, Jiani
Lan, Bin
Wang, Xuefeng
Liu, Jun
Lin, Jing
Fei, Zhaodong
Zheng, Xiaobin
Chen, Chuanben
author_sort Chen, Yu
collection PubMed
description The PRKDC gene encodes the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein. DNA-PKcs plays an important role in nonhomologous end joining (NHEJ) of DNA double-strand breaks (DSBs) and is also closely related to the establishment of central immune tolerance and the maintenance of chromosome stability. The occurrence and development of different types of tumors and the results of their treatment are also influenced by DNA-PKcs, and it may also predict the results of radiotherapy, chemotherapy, and therapy with immune checkpoint inhibitors (ICIs). Here, we discuss and review the structure and mechanism of action of PRKDC and DNA-PKcs and their relationship with cancer.
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spelling pubmed-85470282021-10-26 Role of PRKDC in cancer initiation, progression, and treatment Chen, Yu Li, Yi Xiong, Jiani Lan, Bin Wang, Xuefeng Liu, Jun Lin, Jing Fei, Zhaodong Zheng, Xiaobin Chen, Chuanben Cancer Cell Int Review The PRKDC gene encodes the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein. DNA-PKcs plays an important role in nonhomologous end joining (NHEJ) of DNA double-strand breaks (DSBs) and is also closely related to the establishment of central immune tolerance and the maintenance of chromosome stability. The occurrence and development of different types of tumors and the results of their treatment are also influenced by DNA-PKcs, and it may also predict the results of radiotherapy, chemotherapy, and therapy with immune checkpoint inhibitors (ICIs). Here, we discuss and review the structure and mechanism of action of PRKDC and DNA-PKcs and their relationship with cancer. BioMed Central 2021-10-26 /pmc/articles/PMC8547028/ /pubmed/34702253 http://dx.doi.org/10.1186/s12935-021-02229-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Yu
Li, Yi
Xiong, Jiani
Lan, Bin
Wang, Xuefeng
Liu, Jun
Lin, Jing
Fei, Zhaodong
Zheng, Xiaobin
Chen, Chuanben
Role of PRKDC in cancer initiation, progression, and treatment
title Role of PRKDC in cancer initiation, progression, and treatment
title_full Role of PRKDC in cancer initiation, progression, and treatment
title_fullStr Role of PRKDC in cancer initiation, progression, and treatment
title_full_unstemmed Role of PRKDC in cancer initiation, progression, and treatment
title_short Role of PRKDC in cancer initiation, progression, and treatment
title_sort role of prkdc in cancer initiation, progression, and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547028/
https://www.ncbi.nlm.nih.gov/pubmed/34702253
http://dx.doi.org/10.1186/s12935-021-02229-8
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