Serial single-cell genomics reveals convergent subclonal evolution of resistance as early-stage breast cancer patients progress on endocrine plus CDK4/6 therapy

Combining cyclin-dependent kinase (CDK) inhibitors with endocrine therapy improves outcomes for metastatic estrogen receptor positive (ER+) breast cancer patients but its value in earlier stage patients is unclear. We examined evolutionary trajectories of early-stage breast cancer tumors, using sing...

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Detalles Bibliográficos
Autores principales: Griffiths, Jason I., Chen, Jinfeng, Cosgrove, Patrick A., O’Dea, Anne, Sharma, Priyanka, Ma, Cynthia, Trivedi, Meghna, Kalinsky, Kevin, Wisinski, Kari B., O’Regan, Ruth, Makhoul, Issam, Spring, Laura M., Bardia, Aditya, Adler, Frederick R., Cohen, Adam L., Chang, Jeffrey T., Khan, Qamar J., Bild, Andrea H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547038/
https://www.ncbi.nlm.nih.gov/pubmed/34712959
http://dx.doi.org/10.1038/s43018-021-00215-7

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