Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in App(NL-G-F), App(NL-F), and 3xTg-AD mouse models

BACKGROUND: In spite of many years of research, our understanding of the molecular bases of Alzheimer’s disease (AD) is still incomplete, and the medical treatments available mainly target the disease symptoms and are hardly effective. Indeed, the modulation of a single target (e.g., β-secretase) ha...

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Detalles Bibliográficos
Autores principales: Pauls, Eduardo, Bayod, Sergi, Mateo, Lídia, Alcalde, Víctor, Juan-Blanco, Teresa, Sánchez-Soto, Marta, Saido, Takaomi C., Saito, Takashi, Berrenguer-Llergo, Antoni, Attolini, Camille Stephan-Otto, Gay, Marina, de Oliveira, Eliandre, Duran-Frigola, Miquel, Aloy, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547095/
https://www.ncbi.nlm.nih.gov/pubmed/34702310
http://dx.doi.org/10.1186/s13073-021-00983-y

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