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Patterns of care for prostate cancer radiotherapy—results from a survey among German-speaking radiation oncologists

BACKGROUND: Emerging moderately hypofractionated and ultra-hypofractionated schemes for radiotherapy (RT) of prostate cancer (PC) have resulted in various treatment options. The aim of this survey was to evaluate recent patterns of care of German-speaking radiation oncologists for RT of PC. METHODS:...

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Autores principales: Vogel, Marco M. E., Dewes, Sabrina, Sage, Eva K., Devecka, Michal, Gschwend, Jürgen E., Schiller, Kilian, Combs, Stephanie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547211/
https://www.ncbi.nlm.nih.gov/pubmed/33506347
http://dx.doi.org/10.1007/s00066-020-01738-1
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author Vogel, Marco M. E.
Dewes, Sabrina
Sage, Eva K.
Devecka, Michal
Gschwend, Jürgen E.
Schiller, Kilian
Combs, Stephanie E.
author_facet Vogel, Marco M. E.
Dewes, Sabrina
Sage, Eva K.
Devecka, Michal
Gschwend, Jürgen E.
Schiller, Kilian
Combs, Stephanie E.
author_sort Vogel, Marco M. E.
collection PubMed
description BACKGROUND: Emerging moderately hypofractionated and ultra-hypofractionated schemes for radiotherapy (RT) of prostate cancer (PC) have resulted in various treatment options. The aim of this survey was to evaluate recent patterns of care of German-speaking radiation oncologists for RT of PC. METHODS: We developed an online survey which we distributed via e‑mail to all registered members of the German Society of Radiation Oncology (DEGRO). The survey was completed by 109 participants between March 3 and April 3, 2020. For evaluation of radiation dose, we used the equivalent dose at fractionation of 2 Gy with α/β = 1.5 Gy, equivalent dose (EQD2 [1.5 Gy]). RESULTS: Median EQD2(1.5 Gy) for definitive RT of the prostate is 77.60 Gy (range: 64.49–84.00) with median single doses (SD) of 2.00 Gy (range: 1.80–3.00), while for postoperative RT of the prostate bed, median EQD2(1.5 Gy) is 66.00 Gy (range: 60.00–74.00) with median SD of 2.00 Gy (range: 1.80–2.00). For definitive RT, the pelvic lymph nodes (LNs) are treated in case of suspect findings in imaging (82.6%) and/or according to risk formulas/tables (78.0%). In the postoperative setting, 78.9% use imaging and 78.0% use the postoperative tumor stage for LN irradiation. In the definitive and postoperative situation, LNs are irradiated with a median EQD2(1.5 Gy) of 47.52 Gy with a range of 42.43–66.00 and 41.76–62.79, respectively. CONCLUSION: German-speaking radiation oncologists’ patterns of care for patients with PC are mainly in line with the published data and treatment recommendation guidelines. However, dose prescription is highly heterogenous for RT of the prostate/prostate bed, while the dose to the pelvic LNs is mainly consistent. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s00066-020-01738-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-85472112021-10-29 Patterns of care for prostate cancer radiotherapy—results from a survey among German-speaking radiation oncologists Vogel, Marco M. E. Dewes, Sabrina Sage, Eva K. Devecka, Michal Gschwend, Jürgen E. Schiller, Kilian Combs, Stephanie E. Strahlenther Onkol Original Article BACKGROUND: Emerging moderately hypofractionated and ultra-hypofractionated schemes for radiotherapy (RT) of prostate cancer (PC) have resulted in various treatment options. The aim of this survey was to evaluate recent patterns of care of German-speaking radiation oncologists for RT of PC. METHODS: We developed an online survey which we distributed via e‑mail to all registered members of the German Society of Radiation Oncology (DEGRO). The survey was completed by 109 participants between March 3 and April 3, 2020. For evaluation of radiation dose, we used the equivalent dose at fractionation of 2 Gy with α/β = 1.5 Gy, equivalent dose (EQD2 [1.5 Gy]). RESULTS: Median EQD2(1.5 Gy) for definitive RT of the prostate is 77.60 Gy (range: 64.49–84.00) with median single doses (SD) of 2.00 Gy (range: 1.80–3.00), while for postoperative RT of the prostate bed, median EQD2(1.5 Gy) is 66.00 Gy (range: 60.00–74.00) with median SD of 2.00 Gy (range: 1.80–2.00). For definitive RT, the pelvic lymph nodes (LNs) are treated in case of suspect findings in imaging (82.6%) and/or according to risk formulas/tables (78.0%). In the postoperative setting, 78.9% use imaging and 78.0% use the postoperative tumor stage for LN irradiation. In the definitive and postoperative situation, LNs are irradiated with a median EQD2(1.5 Gy) of 47.52 Gy with a range of 42.43–66.00 and 41.76–62.79, respectively. CONCLUSION: German-speaking radiation oncologists’ patterns of care for patients with PC are mainly in line with the published data and treatment recommendation guidelines. However, dose prescription is highly heterogenous for RT of the prostate/prostate bed, while the dose to the pelvic LNs is mainly consistent. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s00066-020-01738-1) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2021-01-27 2021 /pmc/articles/PMC8547211/ /pubmed/33506347 http://dx.doi.org/10.1007/s00066-020-01738-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Vogel, Marco M. E.
Dewes, Sabrina
Sage, Eva K.
Devecka, Michal
Gschwend, Jürgen E.
Schiller, Kilian
Combs, Stephanie E.
Patterns of care for prostate cancer radiotherapy—results from a survey among German-speaking radiation oncologists
title Patterns of care for prostate cancer radiotherapy—results from a survey among German-speaking radiation oncologists
title_full Patterns of care for prostate cancer radiotherapy—results from a survey among German-speaking radiation oncologists
title_fullStr Patterns of care for prostate cancer radiotherapy—results from a survey among German-speaking radiation oncologists
title_full_unstemmed Patterns of care for prostate cancer radiotherapy—results from a survey among German-speaking radiation oncologists
title_short Patterns of care for prostate cancer radiotherapy—results from a survey among German-speaking radiation oncologists
title_sort patterns of care for prostate cancer radiotherapy—results from a survey among german-speaking radiation oncologists
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547211/
https://www.ncbi.nlm.nih.gov/pubmed/33506347
http://dx.doi.org/10.1007/s00066-020-01738-1
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